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Items: 1 to 20 of 139

1.

Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions.

Adamczyk AJ, Cao J, Kamerlin SC, Warshel A.

Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14115-20. doi: 10.1073/pnas.1111252108. Epub 2011 Aug 10.

2.

The catalytic effect of dihydrofolate reductase and its mutants is determined by reorganization energies.

Liu H, Warshel A.

Biochemistry. 2007 May 22;46(20):6011-25. Epub 2007 May 1.

PMID:
17469852
3.

A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis.

Bhabha G, Lee J, Ekiert DC, Gam J, Wilson IA, Dyson HJ, Benkovic SJ, Wright PE.

Science. 2011 Apr 8;332(6026):234-8. doi: 10.1126/science.1198542.

4.

On the relationship between thermal stability and catalytic power of enzymes.

Roca M, Liu H, Messer B, Warshel A.

Biochemistry. 2007 Dec 25;46(51):15076-88. Epub 2007 Dec 1.

5.

Catalytic efficiency of enzymes: a theoretical analysis.

Hammes-Schiffer S.

Biochemistry. 2013 Mar 26;52(12):2012-20. doi: 10.1021/bi301515j. Epub 2012 Dec 20. Review.

6.

Relating protein motion to catalysis.

Hammes-Schiffer S, Benkovic SJ.

Annu Rev Biochem. 2006;75:519-41. Review.

PMID:
16756501
7.

Defining the role of active-site loop fluctuations in dihydrofolate reductase catalysis.

McElheny D, Schnell JR, Lansing JC, Dyson HJ, Wright PE.

Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5032-7. Epub 2005 Mar 28.

8.

Evidence that a 'dynamic knockout' in Escherichia coli dihydrofolate reductase does not affect the chemical step of catalysis.

Loveridge EJ, Behiry EM, Guo J, Allemann RK.

Nat Chem. 2012 Mar 11;4(4):292-7. doi: 10.1038/nchem.1296.

PMID:
22437714
9.

Protein isotope effects in dihydrofolate reductase from Geobacillus stearothermophilus show entropic-enthalpic compensatory effects on the rate constant.

Luk LY, Ruiz-Pernía JJ, Dawson WM, Loveridge EJ, Tuñón I, Moliner V, Allemann RK.

J Am Chem Soc. 2014 Dec 10;136(49):17317-23. doi: 10.1021/ja5102536. Epub 2014 Nov 26.

PMID:
25396728
10.

Temporally overlapped but uncoupled motions in dihydrofolate reductase catalysis.

Liu CT, Wang L, Goodey NM, Hanoian P, Benkovic SJ.

Biochemistry. 2013 Aug 13;52(32):5332-4. doi: 10.1021/bi400858m. Epub 2013 Jul 29.

11.

The role of large-scale motions in catalysis by dihydrofolate reductase.

Loveridge EJ, Tey LH, Behiry EM, Dawson WM, Evans RM, Whittaker SB, Günther UL, Williams C, Crump MP, Allemann RK.

J Am Chem Soc. 2011 Dec 21;133(50):20561-70. doi: 10.1021/ja208844j. Epub 2011 Nov 22.

12.

Impact of distal mutations on the network of coupled motions correlated to hydride transfer in dihydrofolate reductase.

Wong KF, Selzer T, Benkovic SJ, Hammes-Schiffer S.

Proc Natl Acad Sci U S A. 2005 May 10;102(19):6807-12. Epub 2005 Apr 5.

14.

Freezing a single distal motion in dihydrofolate reductase.

Sergi A, Watney JB, Wong KF, Hammes-Schiffer S.

J Phys Chem B. 2006 Feb 9;110(5):2435-41.

PMID:
16471835
15.

Backbone dynamics in dihydrofolate reductase complexes: role of loop flexibility in the catalytic mechanism.

Osborne MJ, Schnell J, Benkovic SJ, Dyson HJ, Wright PE.

Biochemistry. 2001 Aug 21;40(33):9846-59.

PMID:
11502178
16.

Perspectives on electrostatics and conformational motions in enzyme catalysis.

Hanoian P, Liu CT, Hammes-Schiffer S, Benkovic S.

Acc Chem Res. 2015 Feb 17;48(2):482-9. doi: 10.1021/ar500390e. Epub 2015 Jan 7. Review.

17.

Dynamics and dissipation in enzyme catalysis.

Boekelheide N, Salomón-Ferrer R, Miller TF 3rd.

Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16159-63. doi: 10.1073/pnas.1106397108. Epub 2011 Sep 19.

18.

Structure, dynamics, and catalytic function of dihydrofolate reductase.

Schnell JR, Dyson HJ, Wright PE.

Annu Rev Biophys Biomol Struct. 2004;33:119-40. Review.

PMID:
15139807
19.

Stretching exercises--flexibility in dihydrofolate reductase catalysis.

Miller GP, Benkovic SJ.

Chem Biol. 1998 May;5(5):R105-13. Review.

20.

Solvent effects on catalysis by Escherichia coli dihydrofolate reductase.

Loveridge EJ, Tey LH, Allemann RK.

J Am Chem Soc. 2010 Jan 27;132(3):1137-43. doi: 10.1021/ja909353c.

PMID:
20047317

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