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Fungal chitin from asthma-associated home environments induces eosinophilic lung infiltration.

Van Dyken SJ, Garcia D, Porter P, Huang X, Quinlan PJ, Blanc PD, Corry DB, Locksley RM.

J Immunol. 2011 Sep 1;187(5):2261-7. doi: 10.4049/jimmunol.1100972. Epub 2011 Aug 8.


Induction of innate immunity by Aspergillus fumigatus cell wall polysaccharides is enhanced by the composite presentation of chitin and beta-glucan.

Dubey LK, Moeller JB, Schlosser A, Sorensen GL, Holmskov U.

Immunobiology. 2014 Mar;219(3):179-88. doi: 10.1016/j.imbio.2013.10.003. Epub 2013 Oct 12.


Eosinophils are recruited in response to chitin exposure and enhance Th2-mediated immune pathology in Aspergillus fumigatus infection.

O'Dea EM, Amarsaikhan N, Li H, Downey J, Steele E, Van Dyken SJ, Locksley RM, Templeton SP.

Infect Immun. 2014 Aug;82(8):3199-205. doi: 10.1128/IAI.01990-14. Epub 2014 May 19.


Role of mammalian chitinases in asthma.

Shuhui L, Mok YK, Wong WS.

Int Arch Allergy Immunol. 2009;149(4):369-77. doi: 10.1159/000205583. Epub 2009 Mar 17. Review.


Lung-homing of endothelial progenitor cells and airway vascularization is only partially dependant on eosinophils in a house dust mite-exposed mouse model of allergic asthma.

Sivapalan N, Wattie J, Inman MD, Sehmi R.

PLoS One. 2014 Oct 3;9(10):e109991. doi: 10.1371/journal.pone.0109991. eCollection 2014.


Dermatophagoides-farinae-induced pulmonary eosinophilic inflammation in mice.

Yu CK, Yang BC, Lee SC, Wang JY, Hsiue TR, Lei HY.

Int Arch Allergy Immunol. 1997 Jan;112(1):73-82.


Pulmonary eosinophilia correlates with allergen deposition to the lower respiratory tract in a mouse model of asthma.

Siddiqui S, Morris J, Avery N, Wyand S, Rood D, Silbart LK.

Clin Exp Allergy. 2008 Aug;38(8):1381-90. doi: 10.1111/j.1365-2222.2008.03009.x. Epub 2008 Jun 4.


Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation.

Zhu Z, Zheng T, Homer RJ, Kim YK, Chen NY, Cohn L, Hamid Q, Elias JA.

Science. 2004 Jun 11;304(5677):1678-82.


AMCase is a crucial regulator of type 2 immune responses to inhaled house dust mites.

Kim LK, Morita R, Kobayashi Y, Eisenbarth SC, Lee CG, Elias J, Eynon EE, Flavell RA.

Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):E2891-9. doi: 10.1073/pnas.1507393112. Epub 2015 May 18.


Chitins and chitosans as immunoadjuvants and non-allergenic drug carriers.

Muzzarelli RA.

Mar Drugs. 2010 Feb 21;8(2):292-312. doi: 10.3390/md8020292. Review.


Chitin, chitinases and chitinase-like proteins in allergic inflammation and tissue remodeling.

Lee CG.

Yonsei Med J. 2009 Feb 28;50(1):22-30. doi: 10.3349/ymj.2009.50.1.22. Epub 2009 Feb 24. Review.


Induction of allergic inflammation in the lungs of sensitized sheep after local challenge with house dust mite.

Bischof RJ, Snibson K, Shaw R, Meeusen EN.

Clin Exp Allergy. 2003 Mar;33(3):367-75.


Fungal exposure modulates the effect of polymorphisms of chitinases on emergency department visits and hospitalizations.

Wu AC, Lasky-Su J, Rogers CA, Klanderman BJ, Litonjua AA.

Am J Respir Crit Care Med. 2010 Oct 1;182(7):884-9. doi: 10.1164/rccm.201003-0322OC. Epub 2010 Jun 10.


Chitinases and chitinase-like proteins in T(H)2 inflammation and asthma.

Elias JA, Homer RJ, Hamid Q, Lee CG.

J Allergy Clin Immunol. 2005 Sep;116(3):497-500. Review.


Complement component 3C3 and C3a receptor are required in chitin-dependent allergic sensitization to Aspergillus fumigatus but dispensable in chitin-induced innate allergic inflammation.

Roy RM, Paes HC, Nanjappa SG, Sorkness R, Gasper D, Sterkel A, Wüthrich M, Klein BS.

MBio. 2013 Apr 2;4(2). pii: e00162-13. doi: 10.1128/mBio.00162-13.


Acidic mammalian chitinase is not a critical target for allergic airway disease.

Fitz LJ, DeClercq C, Brooks J, Kuang W, Bates B, Demers D, Winkler A, Nocka K, Jiao A, Greco RM, Mason LE, Fleming M, Quazi A, Wright J, Goldman S, Hubeau C, Williams CM.

Am J Respir Cell Mol Biol. 2012 Jan;46(1):71-9. doi: 10.1165/rcmb.2011-0095OC.


Chitin induces accumulation in tissue of innate immune cells associated with allergy.

Reese TA, Liang HE, Tager AM, Luster AD, Van Rooijen N, Voehringer D, Locksley RM.

Nature. 2007 May 3;447(7140):92-6. Epub 2007 Apr 22.


Cigarette smoke differentially affects eosinophilia and remodeling in a model of house dust mite asthma.

Botelho FM, Llop-Guevara A, Trimble NJ, Nikota JK, Bauer CM, Lambert KN, Kianpour S, Jordana M, Stämpfli MR.

Am J Respir Cell Mol Biol. 2011 Oct;45(4):753-60. doi: 10.1165/rcmb.2010-0404OC. Epub 2011 Feb 11.


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