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Improving subchondral bone integrity reduces progression of cartilage damage in experimental osteoarthritis preceded by osteoporosis.

Bellido M, Lugo L, Roman-Blas JA, Castañeda S, Calvo E, Largo R, Herrero-Beaumont G.

Osteoarthritis Cartilage. 2011 Oct;19(10):1228-36. doi: 10.1016/j.joca.2011.07.003.


Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis.

Bellido M, Lugo L, Roman-Blas JA, Castañeda S, Caeiro JR, Dapia S, Calvo E, Largo R, Herrero-Beaumont G.

Arthritis Res Ther. 2010;12(4):R152. doi: 10.1186/ar3103. Epub 2010 Aug 2.


Parathyroid hormone (1-34) prevents cartilage degradation and preserves subchondral bone micro-architecture in guinea pigs with spontaneous osteoarthritis.

Yan JY, Tian FM, Wang WY, Cheng Y, Song HP, Zhang YZ, Zhang L.

Osteoarthritis Cartilage. 2014 Nov;22(11):1869-77. doi: 10.1016/j.joca.2014.07.013.


Effects of PTH [1-34] on synoviopathy in an experimental model of osteoarthritis preceded by osteoporosis.

Lugo L, Villalvilla A, Gómez R, Bellido M, Sánchez-Pernaute O, Largo R, Herrero-Beaumont G, Roman-Blas JA.

Osteoarthritis Cartilage. 2012 Dec;20(12):1619-30. doi: 10.1016/j.joca.2012.08.010.


Microstructural alterations of femoral head articular cartilage and subchondral bone in osteoarthritis and osteoporosis.

Bobinac D, Marinovic M, Bazdulj E, Cvijanovic O, Celic T, Maric I, Spanjol J, Cicvaric T.

Osteoarthritis Cartilage. 2013 Nov;21(11):1724-30. doi: 10.1016/j.joca.2013.06.030.


Effects of pamidronate disodium on the loss of osteoarthritic subchondral bone and the expression of cartilaginous and subchondral osteoprotegerin and RANKL in rabbits.

Lv Y, Xia JY, Chen JY, Zhao H, Yan HC, Yang HS, Li Q, Fan YX, Guo KJ, Chen XY.

BMC Musculoskelet Disord. 2014 Nov 6;15:370. doi: 10.1186/1471-2474-15-370.


Alterations in subchondral bone plate, trabecular bone and articular cartilage properties of rabbit femoral condyles at 4 weeks after anterior cruciate ligament transection.

Florea C, Malo MK, Rautiainen J, Mäkelä JT, Fick JM, Nieminen MT, Jurvelin JS, Davidescu A, Korhonen RK.

Osteoarthritis Cartilage. 2015 Mar;23(3):414-22. doi: 10.1016/j.joca.2014.11.023.


Protective effects of the Tougu Xiaotong capsule on morphology and osteoprotegerin/nuclear factor-κB ligand expression in rabbits with knee osteoarthritis.

Chen S, Huang Y, Chen W, Wu G, Liao N, Li X, Huang M, Lin R, Yu C, Li X, Liu X.

Mol Med Rep. 2016 Jan;13(1):419-25. doi: 10.3892/mmr.2015.4547.


Osteoporosis increases the severity of cartilage damage in an experimental model of osteoarthritis in rabbits.

Calvo E, Castañeda S, Largo R, Fernández-Valle ME, Rodríguez-Salvanés F, Herrero-Beaumont G.

Osteoarthritis Cartilage. 2007 Jan;15(1):69-77.


PTH [1-34]-induced alterations of the subchondral bone provoke early osteoarthritis.

Orth P, Cucchiarini M, Wagenpfeil S, Menger MD, Madry H.

Osteoarthritis Cartilage. 2014 Jun;22(6):813-21. doi: 10.1016/j.joca.2014.03.010.


RANKL synthesized by articular chondrocytes contributes to juxta-articular bone loss in chronic arthritis.

Martínez-Calatrava MJ, Prieto-Potín I, Roman-Blas JA, Tardio L, Largo R, Herrero-Beaumont G.

Arthritis Res Ther. 2012 Jun 18;14(3):R149. doi: 10.1186/ar3884.


Enhanced expression of interleukin-6, matrix metalloproteinase-13, and receptor activator of NF-kappaB ligand in cells derived from osteoarthritic subchondral bone.

Sakao K, Takahashi KA, Mazda O, Arai Y, Tonomura H, Inoue A, Saito M, Fujioka M, Takamiya H, Imanishi J, Kubo T.

J Orthop Sci. 2008 May;13(3):202-10. doi: 10.1007/s00776-008-1227-5. Epub 2008 Jun 6.


Bone turnover and articular cartilage differences localized to subchondral cysts in knees with advanced osteoarthritis.

Chen Y, Wang T, Guan M, Zhao W, Leung FK, Pan H, Cao X, Guo XE, Lu WW.

Osteoarthritis Cartilage. 2015 Dec;23(12):2174-83. doi: 10.1016/j.joca.2015.07.012.


Osteoprotegerin inhibits cartilage degradation through an effect on trabecular bone in murine experimental osteoarthritis.

Kadri A, Ea HK, Bazille C, Hannouche D, Lioté F, Cohen-Solal ME.

Arthritis Rheum. 2008 Aug;58(8):2379-86. doi: 10.1002/art.23638.


Effect of antiresorptive and anabolic bone therapy on development of osteoarthritis in a posttraumatic rat model of OA.

Bagi CM, Berryman E, Zakur DE, Wilkie D, Andresen CJ.

Arthritis Res Ther. 2015 Nov 6;17:315. doi: 10.1186/s13075-015-0829-5.


Control of Dkk-1 ameliorates chondrocyte apoptosis, cartilage destruction, and subchondral bone deterioration in osteoarthritic knees.

Weng LH, Wang CJ, Ko JY, Sun YC, Wang FS.

Arthritis Rheum. 2010 May;62(5):1393-402. doi: 10.1002/art.27357.


Enhancement of subchondral bone quality by alendronate administration for the reduction of cartilage degeneration in the early phase of experimental osteoarthritis.

Zhang L, Hu H, Tian F, Song H, Zhang Y.

Clin Exp Med. 2011 Dec;11(4):235-43. doi: 10.1007/s10238-011-0131-z. Epub 2011 Feb 9.


Joint distraction attenuates osteoarthritis by reducing secondary inflammation, cartilage degeneration and subchondral bone aberrant change.

Chen Y, Sun Y, Pan X, Ho K, Li G.

Osteoarthritis Cartilage. 2015 Oct;23(10):1728-35. doi: 10.1016/j.joca.2015.05.018.

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