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Proteomic analysis shows synthetic oleanane triterpenoid binds to mTOR.

Yore MM, Kettenbach AN, Sporn MB, Gerber SA, Liby KT.

PLoS One. 2011;6(7):e22862. doi: 10.1371/journal.pone.0022862. Epub 2011 Jul 27.


Synthetic oleanane triterpenoid, CDDO-Me, induces apoptosis in ovarian cancer cells by inhibiting prosurvival AKT/NF-κB/mTOR signaling.

Gao X, Liu Y, Deeb D, Arbab AS, Guo AM, Dulchavsky SA, Gautam SC.

Anticancer Res. 2011 Nov;31(11):3673-81.


2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer.

Samudio I, Konopleva M, Hail N Jr, Shi YX, McQueen T, Hsu T, Evans R, Honda T, Gribble GW, Sporn M, Gilbert HF, Safe S, Andreeff M.

J Biol Chem. 2005 Oct 28;280(43):36273-82. Epub 2005 Aug 23.


Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease.

Liby KT, Sporn MB.

Pharmacol Rev. 2012 Oct;64(4):972-1003. doi: 10.1124/pr.111.004846. Epub 2012 Sep 10. Review.


Oleanane triterpenoid CDDO-Me inhibits growth and induces apoptosis in prostate cancer cells by independently targeting pro-survival Akt and mTOR.

Deeb D, Gao X, Jiang H, Dulchavsky SA, Gautam SC.

Prostate. 2009 Jun 1;69(8):851-60. doi: 10.1002/pros.20937.


The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid-imidazolide alters transforming growth factor beta-dependent signaling and cell migration by affecting the cytoskeleton and the polarity complex.

To C, Kulkarni S, Pawson T, Honda T, Gribble GW, Sporn MB, Wrana JL, Di Guglielmo GM.

J Biol Chem. 2008 Apr 25;283(17):11700-13. doi: 10.1074/jbc.M704064200. Epub 2008 Feb 18.


Oleanane triterpenoid CDDO-Me inhibits Akt activity without affecting PDK1 kinase or PP2A phosphatase activity in cancer cells.

Liu Y, Gao X, Deeb D, Gautam SC.

Biochem Biophys Res Commun. 2012 Jan 6;417(1):570-5. doi: 10.1016/j.bbrc.2011.12.007. Epub 2011 Dec 8.


Induction of redox imbalance and apoptosis in multiple myeloma cells by the novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid.

Ikeda T, Nakata Y, Kimura F, Sato K, Anderson K, Motoyoshi K, Sporn M, Kufe D.

Mol Cancer Ther. 2004 Jan;3(1):39-45.


Synthetic triterpenoids attenuate cytotoxic retinal injury: cross-talk between Nrf2 and PI3K/AKT signaling through inhibition of the lipid phosphatase PTEN.

Pitha-Rowe I, Liby K, Royce D, Sporn M.

Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5339-47. doi: 10.1167/iovs.09-3648. Epub 2009 Jun 3.


Cytoprotection of human endothelial cells against oxidative stress by 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-Im): application of systems biology to understand the mechanism of action.

Wang X, Bynum JA, Stavchansky S, Bowman PD.

Eur J Pharmacol. 2014 Jul 5;734:122-31. doi: 10.1016/j.ejphar.2014.03.033. Epub 2014 Apr 3.


The novel synthetic triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo.

Place AE, Suh N, Williams CR, Risingsong R, Honda T, Honda Y, Gribble GW, Leesnitzer LM, Stimmel JB, Willson TM, Rosen E, Sporn MB.

Clin Cancer Res. 2003 Jul;9(7):2798-806.


Novel synthetic pyridyl analogues of CDDO-Imidazolide are useful new tools in cancer prevention.

Cao M, Onyango EO, Williams CR, Royce DB, Gribble GW, Sporn MB, Liby KT.

Pharmacol Res. 2015 Oct;100:135-47. doi: 10.1016/j.phrs.2015.07.024. Epub 2015 Jul 31.


The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti-multiple myeloma (MM) activity and overcome bortezomib resistance.

Chauhan D, Li G, Podar K, Hideshima T, Shringarpure R, Catley L, Mitsiades C, Munshi N, Tai YT, Suh N, Gribble GW, Honda T, Schlossman R, Richardson P, Sporn MB, Anderson KC.

Blood. 2004 Apr 15;103(8):3158-66. Epub 2003 Dec 11.


Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole.

Yates MS, Kwak MK, Egner PA, Groopman JD, Bodreddigari S, Sutter TR, Baumgartner KJ, Roebuck BD, Liby KT, Yore MM, Honda T, Gribble GW, Sporn MB, Kensler TW.

Cancer Res. 2006 Feb 15;66(4):2488-94.


The synthetic triterpenoid CDDO-Imidazolide suppresses experimental liver metastasis.

Townson JL, Macdonald IC, Liby KT, Mackenzie L, Dales DW, Hedley BD, Foster PJ, Sporn MB, Chambers AF.

Clin Exp Metastasis. 2011 Mar;28(3):309-17. doi: 10.1007/s10585-011-9374-z. Epub 2011 Jan 15.


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