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Items: 1 to 20 of 94

1.

mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.

Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN, Sabatini DM.

Cell. 2011 Aug 5;146(3):408-20. doi: 10.1016/j.cell.2011.06.034.

2.

Regulation of hepatic lipin-1 by ethanol: role of AMP-activated protein kinase/sterol regulatory element-binding protein 1 signaling in mice.

Hu M, Wang F, Li X, Rogers CQ, Liang X, Finck BN, Mitra MS, Zhang R, Mitchell DA, You M.

Hepatology. 2012 Feb;55(2):437-46. doi: 10.1002/hep.24708. Epub 2011 Dec 29.

3.

Connecting mTORC1 signaling to SREBP-1 activation.

Bakan I, Laplante M.

Curr Opin Lipidol. 2012 Jun;23(3):226-34. doi: 10.1097/MOL.0b013e328352dd03. Review.

PMID:
22449814
4.

Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP.

Ricoult SJ, Yecies JL, Ben-Sahra I, Manning BD.

Oncogene. 2016 Mar 10;35(10):1250-60. doi: 10.1038/onc.2015.179. Epub 2015 Jun 1.

5.

2-(3-Benzoylthioureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ameliorates metabolic disorders in high-fat diet-fed mice.

Zhang J, Zhang LN, Chen DM, Fu YY, Zhang F, Yang LL, Xia CM, Jiang HW, Tang CL, Xie ZF, Yang F, Li J, Tang J, Li JY.

Acta Pharmacol Sin. 2015 Apr;36(4):483-96. doi: 10.1038/aps.2014.149. Epub 2015 Mar 16.

6.

Activation of mTOR modulates SREBP-2 to induce foam cell formation through increased retinoblastoma protein phosphorylation.

Ma KL, Liu J, Wang CX, Ni J, Zhang Y, Wu Y, Lv LL, Ruan XZ, Liu BC.

Cardiovasc Res. 2013 Dec 1;100(3):450-60. doi: 10.1093/cvr/cvt203. Epub 2013 Sep 25.

PMID:
24068000
7.

GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice.

Kammoun HL, Chabanon H, Hainault I, Luquet S, Magnan C, Koike T, Ferré P, Foufelle F.

J Clin Invest. 2009 May;119(5):1201-15. doi: 10.1172/JCI37007. Epub 2009 Apr 13.

8.

The role of lipin-1 in the pathogenesis of alcoholic fatty liver.

Bi L, Jiang Z, Zhou J.

Alcohol Alcohol. 2015 Mar;50(2):146-51. doi: 10.1093/alcalc/agu102. Epub 2015 Jan 16. Review.

PMID:
25595739
9.

Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways.

Yecies JL, Zhang HH, Menon S, Liu S, Yecies D, Lipovsky AI, Gorgun C, Kwiatkowski DJ, Hotamisligil GS, Lee CH, Manning BD.

Cell Metab. 2011 Jul 6;14(1):21-32. doi: 10.1016/j.cmet.2011.06.002. Erratum in: Cell Metab. 2011 Aug 3;14(2):280.

10.

Neuregulin-activated ERBB4 induces the SREBP-2 cholesterol biosynthetic pathway and increases low-density lipoprotein uptake.

Haskins JW, Zhang S, Means RE, Kelleher JK, Cline GW, Canfrán-Duque A, Suárez Y, Stern DF.

Sci Signal. 2015 Nov 3;8(401):ra111. doi: 10.1126/scisignal.aac5124.

11.

Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.

Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM.

Genes Dev. 2010 Jul 1;24(13):1403-17. doi: 10.1101/gad.1901210.

12.

Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase.

Owen JL, Zhang Y, Bae SH, Farooqi MS, Liang G, Hammer RE, Goldstein JL, Brown MS.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16184-9. doi: 10.1073/pnas.1213343109. Epub 2012 Aug 27.

13.

Troxerutin improves hepatic lipid homeostasis by restoring NAD(+)-depletion-mediated dysfunction of lipin 1 signaling in high-fat diet-treated mice.

Zhang ZF, Fan SH, Zheng YL, Lu J, Wu DM, Shan Q, Hu B.

Biochem Pharmacol. 2014 Sep 1;91(1):74-86. doi: 10.1016/j.bcp.2014.07.002. Epub 2014 Jul 12.

PMID:
25026599
14.

mTORC1 controls PNS myelination along the mTORC1-RXRγ-SREBP-lipid biosynthesis axis in Schwann cells.

Norrmén C, Figlia G, Lebrun-Julien F, Pereira JA, Trötzmüller M, Köfeler HC, Rantanen V, Wessig C, van Deijk AL, Smit AB, Verheijen MH, Rüegg MA, Hall MN, Suter U.

Cell Rep. 2014 Oct 23;9(2):646-60. doi: 10.1016/j.celrep.2014.09.001. Epub 2014 Oct 9.

15.

Selective binding of sterol regulatory element-binding protein isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liver.

Bennett MK, Seo YK, Datta S, Shin DJ, Osborne TF.

J Biol Chem. 2008 Jun 6;283(23):15628-37. doi: 10.1074/jbc.M800391200. Epub 2008 Apr 15.

16.

Fisetin regulates obesity by targeting mTORC1 signaling.

Jung CH, Kim H, Ahn J, Jeon TI, Lee DH, Ha TY.

J Nutr Biochem. 2013 Aug;24(8):1547-54. doi: 10.1016/j.jnutbio.2013.01.003. Epub 2013 Mar 18.

PMID:
23517912
17.

Glycosphingolipid deficiency increases the sterol regulatory element-mediated gene transcription.

Ishitsuka R, Hirabayashi Y, Kobayashi T.

Biochem Biophys Res Commun. 2009 Jan 9;378(2):240-3. doi: 10.1016/j.bbrc.2008.11.030. Epub 2008 Nov 17.

PMID:
19017528
18.

Sterol response element binding protein and thyroid transcription factor-1 (Nkx2.1) regulate Abca3 gene expression.

Besnard V, Xu Y, Whitsett JA.

Am J Physiol Lung Cell Mol Physiol. 2007 Dec;293(6):L1395-405. Epub 2007 Sep 21.

19.

MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice.

Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Sowa N, Yahagi N, Shimano H, Matsumura S, Inoue K, Marusawa H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K.

Nat Commun. 2013;4:2883. doi: 10.1038/ncomms3883.

20.

Sterol-mediated regulation of human lipin 1 gene expression in hepatoblastoma cells.

Ishimoto K, Nakamura H, Tachibana K, Yamasaki D, Ota A, Hirano K, Tanaka T, Hamakubo T, Sakai J, Kodama T, Doi T.

J Biol Chem. 2009 Aug 14;284(33):22195-205. doi: 10.1074/jbc.M109.028753. Epub 2009 Jun 24.

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