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Items: 1 to 20 of 120

1.

Development and evaluation of a genomic signature for the prediction and mechanistic assessment of nongenotoxic hepatocarcinogens in the rat.

Fielden MR, Adai A, Dunn RT 2nd, Olaharski A, Searfoss G, Sina J, Aubrecht J, Boitier E, Nioi P, Auerbach S, Jacobson-Kram D, Raghavan N, Yang Y, Kincaid A, Sherlock J, Chen SJ, Car B; Predictive Safety Testing Consortium, Carcinogenicity Working Group.

Toxicol Sci. 2011 Nov;124(1):54-74. doi: 10.1093/toxsci/kfr202. Epub 2011 Aug 2.

PMID:
21813463
2.

A gene expression biomarker provides early prediction and mechanistic assessment of hepatic tumor induction by nongenotoxic chemicals.

Fielden MR, Brennan R, Gollub J.

Toxicol Sci. 2007 Sep;99(1):90-100. Epub 2007 Jun 8.

PMID:
17557906
3.

Interlaboratory evaluation of genomic signatures for predicting carcinogenicity in the rat.

Fielden MR, Nie A, McMillian M, Elangbam CS, Trela BA, Yang Y, Dunn RT 2nd, Dragan Y, Fransson-Stehen R, Bogdanffy M, Adams SP, Foster WR, Chen SJ, Rossi P, Kasper P, Jacobson-Kram D, Tatsuoka KS, Wier PJ, Gollub J, Halbert DN, Roter A, Young JK, Sina JF, Marlowe J, Martus HJ, Aubrecht J, Olaharski AJ, Roome N, Nioi P, Pardo I, Snyder R, Perry R, Lord P, Mattes W, Car BD; Predictive Safety Testing Consortium; Carcinogenicity Working Group.

Toxicol Sci. 2008 May;103(1):28-34. doi: 10.1093/toxsci/kfn022. Epub 2008 Feb 14.

PMID:
18281259
4.

Comparison of the expression profiles induced by genotoxic and nongenotoxic carcinogens in rat liver.

Ellinger-Ziegelbauer H, Stuart B, Wahle B, Bomann W, Ahr HJ.

Mutat Res. 2005 Aug 4;575(1-2):61-84.

PMID:
15890375
5.

Predictive toxicogenomics approaches reveal underlying molecular mechanisms of nongenotoxic carcinogenicity.

Nie AY, McMillian M, Parker JB, Leone A, Bryant S, Yieh L, Bittner A, Nelson J, Carmen A, Wan J, Lord PG.

Mol Carcinog. 2006 Dec;45(12):914-33.

PMID:
16921489
6.

Prediction model of potential hepatocarcinogenicity of rat hepatocarcinogens using a large-scale toxicogenomics database.

Uehara T, Minowa Y, Morikawa Y, Kondo C, Maruyama T, Kato I, Nakatsu N, Igarashi Y, Ono A, Hayashi H, Mitsumori K, Yamada H, Ohno Y, Urushidani T.

Toxicol Appl Pharmacol. 2011 Sep 15;255(3):297-306. doi: 10.1016/j.taap.2011.07.001. Epub 2011 Jul 19.

PMID:
21784091
7.

Identification of specific mRNA signatures as fingerprints for carcinogenesis in mice induced by genotoxic and nongenotoxic hepatocarcinogens.

Kossler N, Matheis KA, Ostenfeldt N, Bach Toft D, Dhalluin S, Deschl U, Kalkuhl A.

Toxicol Sci. 2015 Feb;143(2):277-95. doi: 10.1093/toxsci/kfu248. Epub 2014 Nov 18.

PMID:
25410580
8.

Comparison of hepatocarcinogen-induced gene expression profiles in conventional primary rat hepatocytes with in vivo rat liver.

Doktorova TY, Ellinger-Ziegelbauer H, Vinken M, Vanhaecke T, van Delft J, Kleinjans J, Ahr HJ, Rogiers V.

Arch Toxicol. 2012 Sep;86(9):1399-411. doi: 10.1007/s00204-012-0847-x. Epub 2012 Apr 8.

PMID:
22484513
9.

Characteristic expression profiles induced by genotoxic carcinogens in rat liver.

Ellinger-Ziegelbauer H, Stuart B, Wahle B, Bomann W, Ahr HJ.

Toxicol Sci. 2004 Jan;77(1):19-34. Epub 2003 Nov 4.

PMID:
14600272
10.
11.

Prediction of a carcinogenic potential of rat hepatocarcinogens using toxicogenomics analysis of short-term in vivo studies.

Ellinger-Ziegelbauer H, Gmuender H, Bandenburg A, Ahr HJ.

Mutat Res. 2008 Jan 1;637(1-2):23-39. Epub 2007 Jul 5.

PMID:
17689568
12.

Comparative analysis of predictive models for nongenotoxic hepatocarcinogenicity using both toxicogenomics and quantitative structure-activity relationships.

Liu Z, Kelly R, Fang H, Ding D, Tong W.

Chem Res Toxicol. 2011 Jul 18;24(7):1062-70. doi: 10.1021/tx2000637. Epub 2011 Jun 20.

PMID:
21627106
13.

Differential display in rat livers treated for 13 weeks with phenobarbital implicates a role for metabolic and oxidative stress in nongenotoxic carcinogenicity.

Elrick MM, Kramer JA, Alden CL, Blomme EA, Bunch RT, Cabonce MA, Curtiss SW, Kier LD, Kolaja KL, Rodi CP, Morris DL.

Toxicol Pathol. 2005;33(1):118-26.

PMID:
15805063
14.

Characterizing and predicting carcinogenicity and mode of action using conventional and toxicogenomics methods.

Waters MD, Jackson M, Lea I.

Mutat Res. 2010 Dec;705(3):184-200. doi: 10.1016/j.mrrev.2010.04.005. Epub 2010 Apr 24. Review.

PMID:
20399889
15.

A toxicogenomic approach for the prediction of murine hepatocarcinogenesis using ensemble feature selection.

Eichner J, Kossler N, Wrzodek C, Kalkuhl A, Bach Toft D, Ostenfeldt N, Richard V, Zell A.

PLoS One. 2013 Sep 10;8(9):e73938. doi: 10.1371/journal.pone.0073938. eCollection 2013.

16.

A toxicogenomics approach for early assessment of potential non-genotoxic hepatocarcinogenicity of chemicals in rats.

Uehara T, Hirode M, Ono A, Kiyosawa N, Omura K, Shimizu T, Mizukawa Y, Miyagishima T, Nagao T, Urushidani T.

Toxicology. 2008 Aug 19;250(1):15-26. doi: 10.1016/j.tox.2008.05.013. Epub 2008 May 29.

PMID:
18619722
17.

Acute molecular markers of rodent hepatic carcinogenesis identified by transcription profiling.

Kramer JA, Curtiss SW, Kolaja KL, Alden CL, Blomme EA, Curtiss WC, Davila JC, Jackson CJ, Bunch RT.

Chem Res Toxicol. 2004 Apr;17(4):463-70.

PMID:
15089088
18.

Evaluation of toxicogenomics approaches for assessing the risk of nongenotoxic carcinogenicity in rat liver.

Eichner J, Wrzodek C, Römer M, Ellinger-Ziegelbauer H, Zell A.

PLoS One. 2014 May 14;9(5):e97678. doi: 10.1371/journal.pone.0097678. eCollection 2014.

19.

Prediction of non-genotoxic carcinogenesis in rats using changes in gene expression following acute dosing.

Nioi P, Pardo ID, Sherratt PJ, Snyder RD.

Chem Biol Interact. 2008 Apr 15;172(3):206-15. doi: 10.1016/j.cbi.2008.01.009. Epub 2008 Feb 1. Corrected and republished in: Chem Biol Interact. 2008 Nov 25;176(2-3):252-60.

PMID:
18328469
20.

Diethylnitrosamine initiation does not alter clofibric acid-induced hepatocarcinogenesis in the rat.

Michel C, Desdouets C, Slaoui M, Isaacs KR, Roberts RA, Boitier E.

Toxicol Sci. 2007 Sep;99(1):58-69. Epub 2007 Jun 30.

PMID:
17602206

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