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Items: 1 to 20 of 121

1.

Regulation of TFEB and V-ATPases by mTORC1.

Peña-Llopis S, Vega-Rubin-de-Celis S, Schwartz JC, Wolff NC, Tran TA, Zou L, Xie XJ, Corey DR, Brugarolas J.

EMBO J. 2011 Jul 29;30(16):3242-58. doi: 10.1038/emboj.2011.257.

2.

TFEB, a novel mTORC1 effector implicated in lysosome biogenesis, endocytosis and autophagy.

Peña-Llopis S, Brugarolas J.

Cell Cycle. 2011 Dec 1;10(23):3987-8. doi: 10.4161/cc.10.23.18251. Epub 2011 Dec 1. No abstract available.

3.

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB.

Settembre C, Zoncu R, Medina DL, Vetrini F, Erdin S, Erdin S, Huynh T, Ferron M, Karsenty G, Vellard MC, Facchinetti V, Sabatini DM, Ballabio A.

EMBO J. 2012 Mar 7;31(5):1095-108. doi: 10.1038/emboj.2012.32. Epub 2012 Feb 17.

4.

The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis.

Roczniak-Ferguson A, Petit CS, Froehlich F, Qian S, Ky J, Angarola B, Walther TC, Ferguson SM.

Sci Signal. 2012 Jun 12;5(228):ra42. doi: 10.1126/scisignal.2002790.

5.

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB.

Martina JA, Chen Y, Gucek M, Puertollano R.

Autophagy. 2012 Jun;8(6):903-14. doi: 10.4161/auto.19653. Epub 2012 May 11.

6.

Increased lysosomal biogenesis in activated microglia and exacerbated neuronal damage after traumatic brain injury in progranulin-deficient mice.

Tanaka Y, Matsuwaki T, Yamanouchi K, Nishihara M.

Neuroscience. 2013 Oct 10;250:8-19. doi: 10.1016/j.neuroscience.2013.06.049. Epub 2013 Jul 2.

PMID:
23830905
7.

TFEBulous control of traffic by mTOR.

Jacinto E.

EMBO J. 2011 Aug 17;30(16):3215-6. doi: 10.1038/emboj.2011.258. No abstract available.

8.

Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion.

Zhou J, Tan SH, Nicolas V, Bauvy C, Yang ND, Zhang J, Xue Y, Codogno P, Shen HM.

Cell Res. 2013 Apr;23(4):508-23. doi: 10.1038/cr.2013.11. Epub 2013 Jan 22.

9.

TFEB and the CLEAR network.

Settembre C, Medina DL.

Methods Cell Biol. 2015;126:45-62. doi: 10.1016/bs.mcb.2014.11.011. Epub 2015 Jan 19.

PMID:
25665440
10.

V-ATPase: a master effector of E2F1-mediated lysosomal trafficking, mTORC1 activation and autophagy.

Meo-Evoli N, Almacellas E, Massucci FA, Gentilella A, Ambrosio S, Kozma SC, Thomas G, Tauler A.

Oncotarget. 2015 Sep 29;6(29):28057-70. doi: 10.18632/oncotarget.4812.

11.

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase.

Zoncu R, Bar-Peled L, Efeyan A, Wang S, Sancak Y, Sabatini DM.

Science. 2011 Nov 4;334(6056):678-83. doi: 10.1126/science.1207056.

12.

Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes.

Martina JA, Puertollano R.

J Cell Biol. 2013 Feb 18;200(4):475-91. doi: 10.1083/jcb.201209135. Epub 2013 Feb 11.

13.

Pharmacological inhibition of lysosomes activates the MTORC1 signaling pathway in chondrocytes in an autophagy-independent manner.

Newton PT, Vuppalapati KK, Bouderlique T, Chagin AS.

Autophagy. 2015;11(9):1594-607. doi: 10.1080/15548627.2015.1068489.

14.

Regulated assembly of vacuolar ATPase is increased during cluster disruption-induced maturation of dendritic cells through a phosphatidylinositol 3-kinase/mTOR-dependent pathway.

Liberman R, Bond S, Shainheit MG, Stadecker MJ, Forgac M.

J Biol Chem. 2014 Jan 17;289(3):1355-63. doi: 10.1074/jbc.M113.524561. Epub 2013 Nov 22.

15.

Requirement for lysosomal localization of mTOR for its activation differs between leucine and other amino acids.

Averous J, Lambert-Langlais S, Carraro V, Gourbeyre O, Parry L, B'Chir W, Muranishi Y, Jousse C, Bruhat A, Maurin AC, Proud CG, Fafournoux P.

Cell Signal. 2014 Sep;26(9):1918-27. doi: 10.1016/j.cellsig.2014.04.019. Epub 2014 May 2.

PMID:
24793303
16.

Drosophila Mitf regulates the V-ATPase and the lysosomal-autophagic pathway.

Bouché V, Espinosa AP, Leone L, Sardiello M, Ballabio A, Botas J.

Autophagy. 2016;12(3):484-98. doi: 10.1080/15548627.2015.1134081.

17.

The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris.

Martina JA, Diab HI, Lishu L, Jeong-A L, Patange S, Raben N, Puertollano R.

Sci Signal. 2014 Jan 21;7(309):ra9. doi: 10.1126/scisignal.2004754.

18.

Orexin/hypocretin activates mTOR complex 1 (mTORC1) via an Erk/Akt-independent and calcium-stimulated lysosome v-ATPase pathway.

Wang Z, Liu S, Kakizaki M, Hirose Y, Ishikawa Y, Funato H, Yanagisawa M, Yu Y, Liu Q.

J Biol Chem. 2014 Nov 14;289(46):31950-9. doi: 10.1074/jbc.M114.600015. Epub 2014 Oct 2.

19.

Metabolism. Differential regulation of mTORC1 by leucine and glutamine.

Jewell JL, Kim YC, Russell RC, Yu FX, Park HW, Plouffe SW, Tagliabracci VS, Guan KL.

Science. 2015 Jan 9;347(6218):194-8. doi: 10.1126/science.1259472. Epub 2015 Jan 7.

20.

Amino Acid Availability Modulates Vacuolar H+-ATPase Assembly.

Stransky LA, Forgac M.

J Biol Chem. 2015 Nov 6;290(45):27360-9. doi: 10.1074/jbc.M115.659128. Epub 2015 Sep 16.

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