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Items: 1 to 20 of 101

1.

Regulation of HMG-CoA reductase in mammals and yeast.

Burg JS, Espenshade PJ.

Prog Lipid Res. 2011 Oct;50(4):403-10. doi: 10.1016/j.plipres.2011.07.002. Epub 2011 Jul 23. Review.

2.

Dislocation of HMG-CoA reductase and Insig-1, two polytopic endoplasmic reticulum proteins, en route to proteasomal degradation.

Leichner GS, Avner R, Harats D, Roitelman J.

Mol Biol Cell. 2009 Jul;20(14):3330-41. doi: 10.1091/mbc.E08-09-0953. Epub 2009 May 20.

3.

Insig regulates HMG-CoA reductase by controlling enzyme phosphorylation in fission yeast.

Burg JS, Powell DW, Chai R, Hughes AL, Link AJ, Espenshade PJ.

Cell Metab. 2008 Dec;8(6):522-31. doi: 10.1016/j.cmet.2008.09.004.

4.
5.

An oxysterol-derived positive signal for 3-hydroxy- 3-methylglutaryl-CoA reductase degradation in yeast.

Gardner RG, Shan H, Matsuda SP, Hampton RY.

J Biol Chem. 2001 Mar 23;276(12):8681-94. Epub 2000 Dec 27.

6.

Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain.

Sever N, Yang T, Brown MS, Goldstein JL, DeBose-Boyd RA.

Mol Cell. 2003 Jan;11(1):25-33.

10.

Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system.

Tsai YC, Leichner GS, Pearce MM, Wilson GL, Wojcikiewicz RJ, Roitelman J, Weissman AM.

Mol Biol Cell. 2012 Dec;23(23):4484-94. doi: 10.1091/mbc.E12-08-0631. Epub 2012 Oct 19.

11.

INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins.

Flury I, Garza R, Shearer A, Rosen J, Cronin S, Hampton RY.

EMBO J. 2005 Nov 16;24(22):3917-26. Epub 2005 Nov 3.

12.

Lipid-regulated degradation of HMG-CoA reductase and Insig-1 through distinct mechanisms in insect cells.

Faulkner RA, Nguyen AD, Jo Y, DeBose-Boyd RA.

J Lipid Res. 2013 Apr;54(4):1011-22. doi: 10.1194/jlr.M033639. Epub 2013 Feb 12.

13.
14.

The 3-hydroxy-3-methylglutaryl coenzyme-A reductases from fungi: a proposal as a therapeutic target and as a study model.

Andrade-Pavón D, Sánchez-Sandoval E, Rosales-Acosta B, Ibarra JA, Tamariz J, Hernández-Rodríguez C, Villa-Tanaca L.

Rev Iberoam Micol. 2014 Jan-Mar;31(1):81-5. doi: 10.1016/j.riam.2013.10.004. Epub 2013 Nov 20. Review.

PMID:
24270073
15.

The effects of statins on the mevalonic acid pathway in recombinant yeast strains expressing human HMG-CoA reductase.

Maciejak A, Leszczynska A, Warchol I, Gora M, Kaminska J, Plochocka D, Wysocka-Kapcinska M, Tulacz D, Siedlecka J, Swiezewska E, Sojka M, Danikiewicz W, Odolczyk N, Szkopinska A, Sygitowicz G, Burzynska B.

BMC Biotechnol. 2013 Aug 30;13:68. doi: 10.1186/1472-6750-13-68.

16.

Arabidopsis 3-hydroxy-3-methylglutaryl-CoA reductase is regulated at the post-translational level in response to alterations of the sphingolipid and the sterol biosynthetic pathways.

Nieto B, Forés O, Arró M, Ferrer A.

Phytochemistry. 2009 Jan;70(1):53-9. doi: 10.1016/j.phytochem.2008.10.010. Epub 2008 Nov 27.

PMID:
19041104
17.

Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast.

Theesfeld CL, Hampton RY.

J Biol Chem. 2013 Mar 22;288(12):8519-30. doi: 10.1074/jbc.M112.404517. Epub 2013 Jan 10.

18.

Enhanced production of coenzyme Q10 by overexpressing HMG-CoA reductase and induction with arachidonic acid in Schizosaccharomyces pombe.

Cheng B, Yuan QP, Sun XX, Li WJ.

Appl Biochem Biotechnol. 2010 Jan;160(2):523-31. doi: 10.1007/s12010-008-8386-x. Epub 2008 Nov 26.

PMID:
19034698
19.

The sterol-sensing domain (SSD) directly mediates signal-regulated endoplasmic reticulum-associated degradation (ERAD) of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase isozyme Hmg2.

Theesfeld CL, Pourmand D, Davis T, Garza RM, Hampton RY.

J Biol Chem. 2011 Jul 29;286(30):26298-307. doi: 10.1074/jbc.M111.244798. Epub 2011 May 31.

20.

Insig-mediated, sterol-accelerated degradation of the membrane domain of hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase in insect cells.

Nguyen AD, Lee SH, DeBose-Boyd RA.

J Biol Chem. 2009 Sep 25;284(39):26778-88. doi: 10.1074/jbc.M109.032342. Epub 2009 Jul 28.

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