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Items: 1 to 20 of 98

1.

Fyn, a potential target for Alzheimer's disease.

Yang K, Belrose J, Trepanier CH, Lei G, Jackson MF, MacDonald JF.

J Alzheimers Dis. 2011;27(2):243-52. doi: 10.3233/JAD-2011-110353. Review.

PMID:
21799250
2.

Altered p59Fyn kinase expression accompanies disease progression in Alzheimer's disease: implications for its functional role.

Ho GJ, Hashimoto M, Adame A, Izu M, Alford MF, Thal LJ, Hansen LA, Masliah E.

Neurobiol Aging. 2005 May;26(5):625-35.

PMID:
15708437
3.

The complex PrP(c)-Fyn couples human oligomeric Aβ with pathological tau changes in Alzheimer's disease.

Larson M, Sherman MA, Amar F, Nuvolone M, Schneider JA, Bennett DA, Aguzzi A, Lesné SE.

J Neurosci. 2012 Nov 21;32(47):16857-71a. doi: 10.1523/JNEUROSCI.1858-12.2012.

4.

Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau.

Usardi A, Pooler AM, Seereeram A, Reynolds CH, Derkinderen P, Anderton B, Hanger DP, Noble W, Williamson R.

FEBS J. 2011 Aug;278(16):2927-37. doi: 10.1111/j.1742-4658.2011.08218.x. Epub 2011 Jul 7.

5.

Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice.

Chin J, Palop JJ, Yu GQ, Kojima N, Masliah E, Mucke L.

J Neurosci. 2004 May 12;24(19):4692-7.

6.

Disease-related modifications in tau affect the interaction between Fyn and Tau.

Bhaskar K, Yen SH, Lee G.

J Biol Chem. 2005 Oct 21;280(42):35119-25. Epub 2005 Aug 22.

7.

Fyn kinases play a critical role in neuronal apoptosis induced by oxygen and glucose deprivation or amyloid-β peptide treatment.

Du CP, Tan R, Hou XY.

CNS Neurosci Ther. 2012 Sep;18(9):754-61. doi: 10.1111/j.1755-5949.2012.00357.x. Epub 2012 Jun 18.

PMID:
22709448
8.

Phosphorylation of tau by fyn: implications for Alzheimer's disease.

Lee G, Thangavel R, Sharma VM, Litersky JM, Bhaskar K, Fang SM, Do LH, Andreadis A, Van Hoesen G, Ksiezak-Reding H.

J Neurosci. 2004 Mar 3;24(9):2304-12.

9.

Alzheimer's amyloid-β oligomers rescue cellular prion protein induced tau reduction via the Fyn pathway.

Chen RJ, Chang WW, Lin YC, Cheng PL, Chen YR.

ACS Chem Neurosci. 2013 Sep 18;4(9):1287-96. doi: 10.1021/cn400085q. Epub 2013 Jul 18.

10.

Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase.

Derkinderen P, Scales TM, Hanger DP, Leung KY, Byers HL, Ward MA, Lenz C, Price C, Bird IN, Perera T, Kellie S, Williamson R, Noble W, Van Etten RA, Leroy K, Brion JP, Reynolds CH, Anderton BH.

J Neurosci. 2005 Jul 13;25(28):6584-93.

11.
12.

Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease.

Chin J, Palop JJ, Puoliväli J, Massaro C, Bien-Ly N, Gerstein H, Scearce-Levie K, Masliah E, Mucke L.

J Neurosci. 2005 Oct 19;25(42):9694-703.

13.

Aberrant phosphorylation in the pathogenesis of Alzheimer's disease.

Chung SH.

BMB Rep. 2009 Aug 31;42(8):467-74. Review.

14.

FK506 reduces amyloid plaque burden and induces MMP-9 in AβPP/PS1 double transgenic mice.

Hong HS, Hwang JY, Son SM, Kim YH, Moon M, Inhee MJ.

J Alzheimers Dis. 2010;22(1):97-105. doi: 10.3233/JAD-2010-100261.

PMID:
20847451
15.

[Alzheimer disease: cellular and molecular aspects].

Octave JN.

Bull Mem Acad R Med Belg. 2005;160(10-12):445-9; discussion 450-1. French.

PMID:
16768248
16.

[Pathological changes induced by amyloid-β in Alzheimer's disease].

Takata K, Kitamura Y, Taniguchi T.

Yakugaku Zasshi. 2011 Jan;131(1):3-11. Review. Japanese.

17.

Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease.

Roberson ED, Halabisky B, Yoo JW, Yao J, Chin J, Yan F, Wu T, Hamto P, Devidze N, Yu GQ, Palop JJ, Noebels JL, Mucke L.

J Neurosci. 2011 Jan 12;31(2):700-11. doi: 10.1523/JNEUROSCI.4152-10.2011.

18.

miR-106b inhibits tau phosphorylation at Tyr18 by targeting Fyn in a model of Alzheimer's disease.

Liu W, Zhao J, Lu G.

Biochem Biophys Res Commun. 2016 Sep 16;478(2):852-7. doi: 10.1016/j.bbrc.2016.08.037. Epub 2016 Aug 9.

PMID:
27520374
19.

Caspase-6 as a novel early target in the treatment of Alzheimer's disease.

LeBlanc AC.

Eur J Neurosci. 2013 Jun;37(12):2005-18. doi: 10.1111/ejn.12250. Review.

PMID:
23773070
20.

Monoamine oxidase inhibitors: promising therapeutic agents for Alzheimer's disease (Review).

Cai Z.

Mol Med Rep. 2014 May;9(5):1533-41. doi: 10.3892/mmr.2014.2040. Epub 2014 Mar 11. Review.

PMID:
24626484

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