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Items: 1 to 20 of 115


Premature activation of the paramyxovirus fusion protein before target cell attachment with corruption of the viral fusion machinery.

Farzan SF, Palermo LM, Yokoyama CC, Orefice G, Fornabaio M, Sarkar A, Kellogg GE, Greengard O, Porotto M, Moscona A.

J Biol Chem. 2011 Nov 4;286(44):37945-54. doi: 10.1074/jbc.M111.256248. Epub 2011 Jul 28.


Interaction between the hemagglutinin-neuraminidase and fusion glycoproteins of human parainfluenza virus type III regulates viral growth in vivo.

Xu R, Palmer SG, Porotto M, Palermo LM, Niewiesk S, Wilson IA, Moscona A.

MBio. 2013 Oct 22;4(5):e00803-13. doi: 10.1128/mBio.00803-13.


Paramyxovirus membrane fusion: lessons from the F and HN atomic structures.

Lamb RA, Paterson RG, Jardetzky TS.

Virology. 2006 Jan 5;344(1):30-7. Review.


Fusion activation through attachment protein stalk domains indicates a conserved core mechanism of paramyxovirus entry into cells.

Bose S, Song AS, Jardetzky TS, Lamb RA.

J Virol. 2014 Apr;88(8):3925-41. doi: 10.1128/JVI.03741-13. Epub 2014 Jan 22.


Adaptation of human parainfluenza virus to airway epithelium reveals fusion properties required for growth in host tissue.

Palmer SG, Porotto M, Palermo LM, Cunha LF, Greengard O, Moscona A.

MBio. 2012 Jun 5;3(3). pii: e00137-12. doi: 10.1128/mBio.00137-12. Print 2012.


Measles virus fusion machinery activated by sialic acid binding globular domain.

Talekar A, Moscona A, Porotto M.

J Virol. 2013 Dec;87(24):13619-27. doi: 10.1128/JVI.02256-13. Epub 2013 Oct 9.


Mechanism of fusion triggering by human parainfluenza virus type III: communication between viral glycoproteins during entry.

Porotto M, Palmer SG, Palermo LM, Moscona A.

J Biol Chem. 2012 Jan 2;287(1):778-93. doi: 10.1074/jbc.M111.298059. Epub 2011 Nov 22.


Fusion activation by a headless parainfluenza virus 5 hemagglutinin-neuraminidase stalk suggests a modular mechanism for triggering.

Bose S, Zokarkar A, Welch BD, Leser GP, Jardetzky TS, Lamb RA.

Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):E2625-34. Epub 2012 Sep 4.


Spring-loaded model revisited: paramyxovirus fusion requires engagement of a receptor binding protein beyond initial triggering of the fusion protein.

Porotto M, Devito I, Palmer SG, Jurgens EM, Yee JL, Yokoyama CC, Pessi A, Moscona A.

J Virol. 2011 Dec;85(24):12867-80. doi: 10.1128/JVI.05873-11. Epub 2011 Oct 5.


Probing the functions of the paramyxovirus glycoproteins F and HN with a panel of synthetic antibodies.

Welch BD, Paduch M, Leser GP, Bergman Z, Kors CA, Paterson RG, Jardetzky TS, Kossiakoff AA, Lamb RA.

J Virol. 2014 Oct;88(20):11713-25. doi: 10.1128/JVI.01707-14. Epub 2014 Aug 13.


Multiple Strategies Reveal a Bidentate Interaction between the Nipah Virus Attachment and Fusion Glycoproteins.

Stone JA, Vemulapati BM, Bradel-Tretheway B, Aguilar HC.

J Virol. 2016 Nov 14;90(23):10762-10773. Print 2016 Dec 1.


Bimolecular complementation of paramyxovirus fusion and hemagglutinin-neuraminidase proteins enhances fusion: implications for the mechanism of fusion triggering.

Connolly SA, Leser GP, Jardetzky TS, Lamb RA.

J Virol. 2009 Nov;83(21):10857-68. doi: 10.1128/JVI.01191-09. Epub 2009 Aug 26.


Thiol/disulfide exchange is required for membrane fusion directed by the Newcastle disease virus fusion protein.

Jain S, McGinnes LW, Morrison TG.

J Virol. 2007 Mar;81(5):2328-39. Epub 2006 Dec 6.


Structure and function of a paramyxovirus fusion protein.

Morrison TG.

Biochim Biophys Acta. 2003 Jul 11;1614(1):73-84. Review.


Regulation of paramyxovirus fusion activation: the hemagglutinin-neuraminidase protein stabilizes the fusion protein in a pretriggered state.

Porotto M, Salah ZW, Gui L, DeVito I, Jurgens EM, Lu H, Yokoyama CC, Palermo LM, Lee KK, Moscona A.

J Virol. 2012 Dec;86(23):12838-48. doi: 10.1128/JVI.01965-12. Epub 2012 Sep 19.


Mutagenesis of Paramyxovirus Hemagglutinin-Neuraminidase Membrane-Proximal Stalk Region Influences Stability, Receptor Binding, and Neuraminidase Activity.

Adu-Gyamfi E, Kim LS, Jardetzky TS, Lamb RA.

J Virol. 2016 Aug 12;90(17):7778-88. doi: 10.1128/JVI.00896-16. Print 2016 Sep 1.


Mutations in the parainfluenza virus 5 fusion protein reveal domains important for fusion triggering and metastability.

Bose S, Heath CM, Shah PA, Alayyoubi M, Jardetzky TS, Lamb RA.

J Virol. 2013 Dec;87(24):13520-31. doi: 10.1128/JVI.02123-13. Epub 2013 Oct 2.

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