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Phosphodiesterase 5 inhibition attenuates cerebral vasospasm and improves functional recovery after experimental subarachnoid hemorrhage.

Han BH, Vellimana AK, Zhou ML, Milner E, Zipfel GJ.

Neurosurgery. 2012 Jan;70(1):178-86; discussion 186-7. doi: 10.1227/NEU.0b013e31822ec2b0.


Systemic administration of phosphodiesterase V inhibitor, sildenafil citrate, for attenuation of cerebral vasospasm after experimental subarachnoid hemorrhage.

Atalay B, Caner H, Cekinmez M, Ozen O, Celasun B, Altinors N.

Neurosurgery. 2006 Nov;59(5):1102-7; discussion 1107-8.


Type V phosphodiesterase expression in cerebral arteries with vasospasm after subarachnoid hemorrhage in a canine model.

Inoha S, Inamura T, Ikezaki K, Nakamizo A, Amano T, Fukui M.

Neurol Res. 2002 Sep;24(6):607-12.


A Phase I proof-of-concept and safety trial of sildenafil to treat cerebral vasospasm following subarachnoid hemorrhage.

Washington CW, Derdeyn CP, Dhar R, Arias EJ, Chicoine MR, Cross DT, Dacey RG Jr, Han BH, Moran CJ, Rich KM, Vellimana AK, Zipfel GJ.

J Neurosurg. 2016 Feb;124(2):318-27. doi: 10.3171/2015.2.JNS142752. Epub 2015 Aug 28.


Phosphodiesterase-5 is a therapeutic target for peripheral neuropathy in diabetic mice.

Wang L, Chopp M, Szalad A, Liu Z, Bolz M, Alvarez FM, Lu M, Zhang L, Cui Y, Zhang RL, Zhang ZG.

Neuroscience. 2011 Oct 13;193:399-410. doi: 10.1016/j.neuroscience.2011.07.039. Epub 2011 Jul 27.


Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats.

Zhang R, Wang Y, Zhang L, Zhang Z, Tsang W, Lu M, Zhang L, Chopp M.

Stroke. 2002 Nov;33(11):2675-80.


Sildenafil improves epicenter vascular perfusion but not hindlimb functional recovery after contusive spinal cord injury in mice.

Myers SA, DeVries WH, Gruenthal MJ, Andres KR, Hagg T, Whittemore SR.

J Neurotrauma. 2012 Feb 10;29(3):528-38. doi: 10.1089/neu.2011.2036. Epub 2011 Dec 15.


The effect of the sildenafil citrate on cerebral vasospasm and apoptosis following experimental subarachnoid hemorrhage in rats.

Gokce C, Gulsen S, Yilmaz C, Guven G, Caner H, Altinors N.

J Neurosurg Sci. 2010 Mar;54(1):29-37.


Antenatal sildenafil treatment attenuates pulmonary hypertension in experimental congenital diaphragmatic hernia.

Luong C, Rey-Perra J, Vadivel A, Gilmour G, Sauve Y, Koonen D, Walker D, Todd KG, Gressens P, Kassiri Z, Nadeem K, Morgan B, Eaton F, Dyck JR, Archer SL, Thébaud B.

Circulation. 2011 May 17;123(19):2120-31. doi: 10.1161/CIRCULATIONAHA.108.845909. Epub 2011 May 2.


Phosphodiesterase 5 (PDE5) inhibition, ANP and NO rapidly reduce epididymal duct contractions, but long-term PDE5 inhibition in vivo does not.

Mietens A, Tasch S, Feuerstacke C, Eichner G, Volkmann J, Schermuly RT, Grimminger F, Müller D, Middendorff R.

Mol Cell Endocrinol. 2012 Feb 26;349(2):145-53. doi: 10.1016/j.mce.2011.09.039. Epub 2011 Oct 2.


2-methoxyestradiol reduces cerebral vasospasm after 48 hours of experimental subarachnoid hemorrhage in rats.

Yan J, Chen C, Lei J, Yang L, Wang K, Liu J, Zhou C.

Exp Neurol. 2006 Dec;202(2):348-56. Epub 2006 Aug 10.


Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage.

McGirt MJ, Lynch JR, Parra A, Sheng H, Pearlstein RD, Laskowitz DT, Pelligrino DA, Warner DS.

Stroke. 2002 Dec;33(12):2950-6.


Acute Effect of Intravenous Sildenafil on Cerebral Blood Flow in Patients with Vasospasm After Subarachnoid Hemorrhage.

Dhar R, Washington C, Diringer M, Zazulia A, Jafri H, Derdeyn C, Zipfel G.

Neurocrit Care. 2016 Oct;25(2):201-4. doi: 10.1007/s12028-016-0243-0.


Gender-specific immunological effects of the phosphodiesterase 5 inhibitor sildenafil in healthy mice.

Karakhanova S, Yang Y, Link J, Soltek S, von Ahn K, Umansky V, Werner J, Bazhin AV.

Mol Immunol. 2013 Dec;56(4):649-59. doi: 10.1016/j.molimm.2013.06.021. Epub 2013 Aug 2.


Brief hyperoxia increases mitochondrial oxidation and increases phosphodiesterase 5 activity in fetal pulmonary artery smooth muscle cells.

Farrow KN, Lee KJ, Perez M, Schriewer JM, Wedgwood S, Lakshminrusimha S, Smith CL, Steinhorn RH, Schumacker PT.

Antioxid Redox Signal. 2012 Aug 1;17(3):460-70. doi: 10.1089/ars.2011.4184. Epub 2012 Mar 8.


Functional recovery in aged and young rats after embolic stroke: treatment with a phosphodiesterase type 5 inhibitor.

Zhang L, Zhang RL, Wang Y, Zhang C, Zhang ZG, Meng H, Chopp M.

Stroke. 2005 Apr;36(4):847-52. Epub 2005 Mar 3.


Pretreatment of sildenafil attenuates ischemia-reperfusion renal injury in rats.

Choi DE, Jeong JY, Lim BJ, Chung S, Chang YK, Lee SJ, Na KR, Kim SY, Shin YT, Lee KW.

Am J Physiol Renal Physiol. 2009 Aug;297(2):F362-70. doi: 10.1152/ajprenal.90609.2008. Epub 2009 May 27.


Phosphodiesterase-5 inhibitor sildenafil prevents neuroinflammation, lowers beta-amyloid levels and improves cognitive performance in APP/PS1 transgenic mice.

Zhang J, Guo J, Zhao X, Chen Z, Wang G, Liu A, Wang Q, Zhou W, Xu Y, Wang C.

Behav Brain Res. 2013 Aug 1;250:230-7. doi: 10.1016/j.bbr.2013.05.017. Epub 2013 May 16.


Chronic inhibition of cGMP-specific phosphodiesterase 5 suppresses endoplasmic reticulum stress in heart failure.

Gong W, Duan Q, Cai Z, Chen C, Ni L, Yan M, Wang X, Cianflone K, Wang DW.

Br J Pharmacol. 2013 Dec;170(7):1396-409. doi: 10.1111/bph.12346.


Role of oxidized LDL and lectin-like oxidized LDL receptor-1 in cerebral vasospasm after subarachnoid hemorrhage.

Matsuda N, Ohkuma H, Naraoka M, Munakata A, Shimamura N, Asano K.

J Neurosurg. 2014 Sep;121(3):621-30. doi: 10.3171/2014.5.JNS132140. Epub 2014 Jun 20.


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