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Identification of a specific intronic PEAR1 gene variant associated with greater platelet aggregability and protein expression.

Faraday N, Yanek LR, Yang XP, Mathias R, Herrera-Galeano JE, Suktitipat B, Qayyum R, Johnson AD, Chen MH, Tofler GH, Ruczinski I, Friedman AD, Gylfason A, Thorsteinsdottir U, Bray PF, O'Donnell CJ, Becker DM, Becker LC.

Blood. 2011 Sep 22;118(12):3367-75. doi: 10.1182/blood-2010-11-320788. Epub 2011 Jul 26.


Targeted deep resequencing identifies coding variants in the PEAR1 gene that play a role in platelet aggregation.

Kim Y, Suktitipat B, Yanek LR, Faraday N, Wilson AF, Becker DM, Becker LC, Mathias RA.

PLoS One. 2013 May 21;8(5):e64179. doi: 10.1371/journal.pone.0064179. Print 2013.


A novel variant in the platelet endothelial aggregation receptor-1 gene is associated with increased platelet aggregability.

Herrera-Galeano JE, Becker DM, Wilson AF, Yanek LR, Bray P, Vaidya D, Faraday N, Becker LC.

Arterioscler Thromb Vasc Biol. 2008 Aug;28(8):1484-90. doi: 10.1161/ATVBAHA.108.168971. Epub 2008 May 29.


Genetic variation in PEAR1 is associated with platelet aggregation and cardiovascular outcomes.

Lewis JP, Ryan K, O'Connell JR, Horenstein RB, Damcott CM, Gibson Q, Pollin TI, Mitchell BD, Beitelshees AL, Pakzy R, Tanner K, Parsa A, Tantry US, Bliden KP, Post WS, Faraday N, Herzog W, Gong Y, Pepine CJ, Johnson JA, Gurbel PA, Shuldiner AR.

Circ Cardiovasc Genet. 2013 Apr;6(2):184-92. doi: 10.1161/CIRCGENETICS.111.964627. Epub 2013 Feb 7.


Genetic determinants of on-aspirin platelet reactivity: focus on the influence of PEAR1.

Würtz M, Nissen PH, Grove EL, Kristensen SD, Hvas AM.

PLoS One. 2014 Oct 31;9(10):e111816. doi: 10.1371/journal.pone.0111816. eCollection 2014.


Genome-wide association study of platelet aggregation in African Americans.

Qayyum R, Becker LC, Becker DM, Faraday N, Yanek LR, Leal SM, Shaw C, Mathias R, Suktitipat B, Bray PF.

BMC Genet. 2015 May 30;16:58. doi: 10.1186/s12863-015-0217-9.


Associations of MDR1, TBXA2R, PLA2G7, and PEAR1 genetic polymorphisms with the platelet activity in Chinese ischemic stroke patients receiving aspirin therapy.

Peng LL, Zhao YQ, Zhou ZY, Jin J, Zhao M, Chen XM, Chen LY, Cai YF, Li JL, Huang M.

Acta Pharmacol Sin. 2016 Nov;37(11):1442-1448. doi: 10.1038/aps.2016.90. Epub 2016 Sep 19.


Allele-specific DNA methylation reinforces PEAR1 enhancer activity.

Izzi B, Pistoni M, Cludts K, Akkor P, Lambrechts D, Verfaillie C, Verhamme P, Freson K, Hoylaerts MF.

Blood. 2016 Aug 18;128(7):1003-12. doi: 10.1182/blood-2015-11-682153. Epub 2016 Jun 16.


Genetic Variation in the Platelet Endothelial Aggregation Receptor 1 Gene Results in Endothelial Dysfunction.

Fisch AS, Yerges-Armstrong LM, Backman JD, Wang H, Donnelly P, Ryan KA, Parihar A, Pavlovich MA, Mitchell BD, O'Connell JR, Herzog W, Harman CR, Wren JD, Lewis JP.

PLoS One. 2015 Sep 25;10(9):e0138795. doi: 10.1371/journal.pone.0138795. eCollection 2015.


Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation.

Nanda N, Bao M, Lin H, Clauser K, Komuves L, Quertermous T, Conley PB, Phillips DR, Hart MJ.

J Biol Chem. 2005 Jul 1;280(26):24680-9. Epub 2005 Apr 25.


A Human Platelet Receptor Protein Microarray Identifies the High Affinity Immunoglobulin E Receptor Subunit α (FcεR1α) as an Activating Platelet Endothelium Aggregation Receptor 1 (PEAR1) Ligand.

Sun Y, Vandenbriele C, Kauskot A, Verhamme P, Hoylaerts MF, Wright GJ.

Mol Cell Proteomics. 2015 May;14(5):1265-74. doi: 10.1074/mcp.M114.046946. Epub 2015 Feb 23.


Different models of inheritance in selected genes in patients with sticky platelet syndrome and fetal loss.

Sokol J, Biringer K, Skerenova M, Stasko J, Kubisz P, Danko J.

Semin Thromb Hemost. 2015 Apr;41(3):330-5. doi: 10.1055/s-0034-1395351. Epub 2015 Feb 19.


A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways.

Jones CI, Bray S, Garner SF, Stephens J, de Bono B, Angenent WG, Bentley D, Burns P, Coffey A, Deloukas P, Earthrowl M, Farndale RW, Hoylaerts MF, Koch K, Rankin A, Rice CM, Rogers J, Samani NJ, Steward M, Walker A, Watkins NA, Akkerman JW, Dudbridge F, Goodall AH, Ouwehand WH; Bloodomics Consortium.

Blood. 2009 Aug 13;114(7):1405-16. doi: 10.1182/blood-2009-02-202614. Epub 2009 May 8.


A novel mechanism of sustained platelet αIIbβ3 activation via PEAR1.

Kauskot A, Di Michele M, Loyen S, Freson K, Verhamme P, Hoylaerts MF.

Blood. 2012 Apr 26;119(17):4056-65. doi: 10.1182/blood-2011-11-392787. Epub 2012 Feb 27.


Identification of PEAR1 SNPs and their influences on the variation in prasugrel pharmacodynamics.

Xiang Q, Cui Y, Zhao X, Zhao N.

Pharmacogenomics. 2013 Jul;14(10):1179-89. doi: 10.2217/pgs.13.108.


Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race.

Edelstein LC, Simon LM, Lindsay CR, Kong X, Teruel-Montoya R, Tourdot BE, Chen ES, Ma L, Coughlin S, Nieman M, Holinstat M, Shaw CA, Bray PF.

Blood. 2014 Nov 27;124(23):3450-8. doi: 10.1182/blood-2014-04-572479. Epub 2014 Oct 7.


A combined genome-wide linkage and association approach to find susceptibility loci for platelet function phenotypes in European American and African American families with coronary artery disease.

Mathias RA, Kim Y, Sung H, Yanek LR, Mantese VJ, Hererra-Galeano JE, Ruczinski I, Wilson AF, Faraday N, Becker LC, Becker DM.

BMC Med Genomics. 2010 Jun 7;3:22. doi: 10.1186/1755-8794-3-22.


PEAR1 is not a major susceptibility gene for cardiovascular disease in a Flemish population.

Yang WY, Petit T, Cauwenberghs N, Zhang ZY, Sheng CS, Thijs L, Salvi E, Izzi B, Vandenbriele C, Wei FF, Gu YM, Jacobs L, Citterio L, Delli Carpini S, Barlassina C, Cusi D, Hoylaerts MF, Verhamme P, Kuznetsova T, Staessen JA.

BMC Med Genet. 2017 Apr 27;18(1):45. doi: 10.1186/s12881-017-0411-x.


Absence of Pear1 does not affect murine platelet function in vivo.

Criel M, Izzi B, Vandenbriele C, Liesenborghs L, Van Kerckhoven S, Lox M, Cludts K, Jones EA, Vanassche T, Verhamme P, Hoylaerts M.

Thromb Res. 2016 Oct;146:76-83. doi: 10.1016/j.thromres.2016.08.026. Epub 2016 Aug 26.


Prospective Evaluation of Genetic Variation in Platelet Endothelial Aggregation Receptor 1 Reveals Aspirin-Dependent Effects on Platelet Aggregation Pathways.

Backman JD, Yerges-Armstrong LM, Horenstein RB, Newcomer S, Shaub S, Morrisey M, Donnelly P, Drolet M, Tanner K, Pavlovich MA, O'Connell JR, Mitchell BD, Lewis JP.

Clin Transl Sci. 2017 Mar;10(2):102-109. doi: 10.1111/cts.12438. Epub 2017 Jan 11.

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