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Items: 1 to 20 of 97

1.

Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1.

Lin W, Cao J, Liu J, Beshiri ML, Fujiwara Y, Francis J, Cherniack AD, Geisen C, Blair LP, Zou MR, Shen X, Kawamori D, Liu Z, Grisanzio C, Watanabe H, Minamishima YA, Zhang Q, Kulkarni RN, Signoretti S, Rodig SJ, Bronson RT, Orkin SH, Tuck DP, Benevolenskaya EV, Meyerson M, Kaelin WG Jr, Yan Q.

Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13379-86. doi: 10.1073/pnas.1110104108. Epub 2011 Jul 25.

2.

The retinoblastoma binding protein RBP2 is an H3K4 demethylase.

Klose RJ, Yan Q, Tothova Z, Yamane K, Erdjument-Bromage H, Tempst P, Gilliland DG, Zhang Y, Kaelin WG Jr.

Cell. 2007 Mar 9;128(5):889-900. Epub 2007 Feb 22.

3.

Dynamic epigenetic regulation by menin during pancreatic islet tumor formation.

Lin W, Watanabe H, Peng S, Francis JM, Kaplan N, Pedamallu CS, Ramachandran A, Agoston A, Bass AJ, Meyerson M.

Mol Cancer Res. 2015 Apr;13(4):689-98. doi: 10.1158/1541-7786.MCR-14-0457. Epub 2014 Dec 23.

4.

Histone demethylase RBP2 promotes lung tumorigenesis and cancer metastasis.

Teng YC, Lee CF, Li YS, Chen YR, Hsiao PW, Chan MY, Lin FM, Huang HD, Chen YT, Jeng YM, Hsu CH, Yan Q, Tsai MD, Juan LJ.

Cancer Res. 2013 Aug 1;73(15):4711-21. doi: 10.1158/0008-5472.CAN-12-3165. Epub 2013 May 30.

5.

Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells.

Váraljai R, Islam AB, Beshiri ML, Rehman J, Lopez-Bigas N, Benevolenskaya EV.

Genes Dev. 2015 Sep 1;29(17):1817-34. doi: 10.1101/gad.264036.115. Epub 2015 Aug 27.

6.

Maintenance of gene silencing by the coordinate action of the H3K9 methyltransferase G9a/KMT1C and the H3K4 demethylase Jarid1a/KDM5A.

Chaturvedi CP, Somasundaram B, Singh K, Carpenedo RL, Stanford WL, Dilworth FJ, Brand M.

Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18845-50. doi: 10.1073/pnas.1213951109. Epub 2012 Oct 29.

7.

Inhibition of osteogenic differentiation of human adipose-derived stromal cells by retinoblastoma binding protein 2 repression of RUNX2-activated transcription.

Ge W, Shi L, Zhou Y, Liu Y, Ma GE, Jiang Y, Xu Y, Zhang X, Feng H.

Stem Cells. 2011 Jul;29(7):1112-25. doi: 10.1002/stem.663.

8.

RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3.

Christensen J, Agger K, Cloos PA, Pasini D, Rose S, Sennels L, Rappsilber J, Hansen KH, Salcini AE, Helin K.

Cell. 2007 Mar 23;128(6):1063-76. Epub 2007 Feb 22.

9.

The histone demethylase RBP2 Is overexpressed in gastric cancer and its inhibition triggers senescence of cancer cells.

Zeng J, Ge Z, Wang L, Li Q, Wang N, Björkholm M, Jia J, Xu D.

Gastroenterology. 2010 Mar;138(3):981-92. doi: 10.1053/j.gastro.2009.10.004. Epub 2009 Oct 20.

PMID:
19850045
10.

The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.

Iwase S, Lan F, Bayliss P, de la Torre-Ubieta L, Huarte M, Qi HH, Whetstine JR, Bonni A, Roberts TM, Shi Y.

Cell. 2007 Mar 23;128(6):1077-88. Epub 2007 Feb 22.

11.

RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation.

Hayakawa T, Ohtani Y, Hayakawa N, Shinmyozu K, Saito M, Ishikawa F, Nakayama J.

Genes Cells. 2007 Jun;12(6):811-26.

12.

Histone demethylase RBP2 is critical for breast cancer progression and metastasis.

Cao J, Liu Z, Cheung WK, Zhao M, Chen SY, Chan SW, Booth CJ, Nguyen DX, Yan Q.

Cell Rep. 2014 Mar 13;6(5):868-77. doi: 10.1016/j.celrep.2014.02.004. Epub 2014 Feb 27.

13.

Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin.

Gonzalo S, García-Cao M, Fraga MF, Schotta G, Peters AH, Cotter SE, Eguía R, Dean DC, Esteller M, Jenuwein T, Blasco MA.

Nat Cell Biol. 2005 Apr;7(4):420-8. Epub 2005 Mar 6.

14.

Aging alters histone H3 lysine 4 methylation in mouse germinal vesicle stage oocytes.

Shao GB, Wang J, Zhang LP, Wu CY, Jin J, Sang JR, Lu HY, Gong AH, Du FY, Peng WX.

Reprod Fertil Dev. 2015 Jan;27(2):419-26. doi: 10.1071/RD13293.

PMID:
24384042
15.

Cadmium induces histone H3 lysine methylation by inhibiting histone demethylase activity.

Xiao C, Liu Y, Xie C, Tu W, Xia Y, Costa M, Zhou X.

Toxicol Sci. 2015 May;145(1):80-9. doi: 10.1093/toxsci/kfv019. Epub 2015 Feb 10.

16.

The KDM5 family of histone demethylases as targets in oncology drug discovery.

Rasmussen PB, Staller P.

Epigenomics. 2014 Jun;6(3):277-86. doi: 10.2217/epi.14.14.

PMID:
25111482
17.

Histone H3K4 demethylases are essential in development and differentiation.

Benevolenskaya EV.

Biochem Cell Biol. 2007 Aug;85(4):435-43. Review.

PMID:
17713579
18.

Physical and functional interactions between the histone H3K4 demethylase KDM5A and the nucleosome remodeling and deacetylase (NuRD) complex.

Nishibuchi G, Shibata Y, Hayakawa T, Hayakawa N, Ohtani Y, Sinmyozu K, Tagami H, Nakayama J.

J Biol Chem. 2014 Oct 17;289(42):28956-70. doi: 10.1074/jbc.M114.573725. Epub 2014 Sep 4.

19.

Critical role of histone demethylase RBP2 in human gastric cancer angiogenesis.

Li L, Wang L, Song P, Geng X, Liang X, Zhou M, Wang Y, Chen C, Jia J, Zeng J.

Mol Cancer. 2014 Apr 9;13:81. doi: 10.1186/1476-4598-13-81.

20.

Histone demethylase RBP2 decreases miR-21 in blast crisis of chronic myeloid leukemia.

Zhou M, Zeng J, Wang X, Wang X, Huang T, Fu Y, Sun T, Jia J, Chen C.

Oncotarget. 2015 Jan 20;6(2):1249-61.

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