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Activation of Akt by the bacterial inositol phosphatase, SopB, is wortmannin insensitive.

Cooper KG, Winfree S, Malik-Kale P, Jolly C, Ireland R, Knodler LA, Steele-Mortimer O.

PLoS One. 2011;6(7):e22260. doi: 10.1371/journal.pone.0022260. Epub 2011 Jul 14.


Multiple host kinases contribute to Akt activation during Salmonella infection.

Roppenser B, Kwon H, Canadien V, Xu R, Devreotes PN, Grinstein S, Brumell JH.

PLoS One. 2013 Aug 22;8(8):e71015. doi: 10.1371/journal.pone.0071015. eCollection 2013.


A second wave of Salmonella T3SS1 activity prolongs the lifespan of infected epithelial cells.

Finn CE, Chong A, Cooper KG, Starr T, Steele-Mortimer O.

PLoS Pathog. 2017 Apr 20;13(4):e1006354. doi: 10.1371/journal.ppat.1006354. eCollection 2017 Apr.


The Salmonella effector protein SopB protects epithelial cells from apoptosis by sustained activation of Akt.

Knodler LA, Finlay BB, Steele-Mortimer O.

J Biol Chem. 2005 Mar 11;280(10):9058-64. Epub 2005 Jan 10.


Activation of Akt/protein kinase B in epithelial cells by the Salmonella typhimurium effector sigD.

Steele-Mortimer O, Knodler LA, Marcus SL, Scheid MP, Goh B, Pfeifer CG, Duronio V, Finlay BB.

J Biol Chem. 2000 Dec 1;275(48):37718-24.


Differential Phosphatidylinositol-3-Kinase-Akt-mTOR Activation by Semliki Forest and Chikungunya Viruses Is Dependent on nsP3 and Connected to Replication Complex Internalization.

Thaa B, Biasiotto R, Eng K, Neuvonen M, Götte B, Rheinemann L, Mutso M, Utt A, Varghese F, Balistreri G, Merits A, Ahola T, McInerney GM.

J Virol. 2015 Nov;89(22):11420-37. doi: 10.1128/JVI.01579-15. Epub 2015 Sep 2. Erratum in: J Virol. 2016 Apr 15;90(8):4256.


Membrane depolarization is the trigger for PI3K/Akt activation and leads to the generation of ROS.

Chatterjee S, Browning EA, Hong N, DeBolt K, Sorokina EM, Liu W, Birnbaum MJ, Fisher AB.

Am J Physiol Heart Circ Physiol. 2012 Jan 1;302(1):H105-14. doi: 10.1152/ajpheart.00298.2011. Epub 2011 Oct 14.


The PI3K/Akt pathway mediates the expression of type I collagen induced by TGF-β2 in human retinal pigment epithelial cells.

Yokoyama K, Kimoto K, Itoh Y, Nakatsuka K, Matsuo N, Yoshioka H, Kubota T.

Graefes Arch Clin Exp Ophthalmol. 2012 Jan;250(1):15-23. doi: 10.1007/s00417-011-1766-x. Epub 2011 Aug 20.


Resveratrol modulates interleukin-1β-induced phosphatidylinositol 3-kinase and nuclear factor κB signaling pathways in human tenocytes.

Busch F, Mobasheri A, Shayan P, Lueders C, Stahlmann R, Shakibaei M.

J Biol Chem. 2012 Nov 2;287(45):38050-63. doi: 10.1074/jbc.M112.377028. Epub 2012 Aug 30.


Aging is associated with decreased pancreatic acinar cell regeneration and phosphatidylinositol 3-kinase/Akt activation.

Watanabe H, Saito H, Rychahou PG, Uchida T, Evers BM.

Gastroenterology. 2005 May;128(5):1391-404.


SopB promotes phosphatidylinositol 3-phosphate formation on Salmonella vacuoles by recruiting Rab5 and Vps34.

Mallo GV, Espina M, Smith AC, Terebiznik MR, Alemán A, Finlay BB, Rameh LE, Grinstein S, Brumell JH.

J Cell Biol. 2008 Aug 25;182(4):741-52. doi: 10.1083/jcb.200804131.


Dual 4- and 5-phosphatase activities regulate SopB-dependent phosphoinositide dynamics to promote bacterial entry.

Piscatelli HL, Li M, Zhou D.

Cell Microbiol. 2016 May;18(5):705-19. doi: 10.1111/cmi.12542. Epub 2015 Dec 9.


Nitric oxide regulates AKT phosphorylation and nuclear translocation in cultured retinal cells.

Mejía-García TA, Portugal CC, Encarnação TG, Prado MA, Paes-de-Carvalho R.

Cell Signal. 2013 Dec;25(12):2424-39. doi: 10.1016/j.cellsig.2013.08.001. Epub 2013 Aug 17.


Endothelial nitric oxide synthase phosphorylation in treadmill-running mice: role of vascular signalling kinases.

Zhang QJ, McMillin SL, Tanner JM, Palionyte M, Abel ED, Symons JD.

J Physiol. 2009 Aug 1;587(Pt 15):3911-20. doi: 10.1113/jphysiol.2009.172916. Epub 2009 Jun 8.


A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells.

Sekulić A, Hudson CC, Homme JL, Yin P, Otterness DM, Karnitz LM, Abraham RT.

Cancer Res. 2000 Jul 1;60(13):3504-13.


Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase.

Ding Z, Liang J, Li J, Lu Y, Ariyaratna V, Lu Z, Davies MA, Westwick JK, Mills GB.

PLoS One. 2010 Mar 26;5(3):e9910. doi: 10.1371/journal.pone.0009910.


Ubiquitination of the bacterial inositol phosphatase, SopB, regulates its biological activity at the plasma membrane.

Knodler LA, Winfree S, Drecktrah D, Ireland R, Steele-Mortimer O.

Cell Microbiol. 2009 Nov;11(11):1652-70. doi: 10.1111/j.1462-5822.2009.01356.x. Epub 2009 Jul 13.

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