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Decreases in IL-7 levels during antiretroviral treatment of HIV infection suggest a primary mechanism of receptor-mediated clearance.

Hodge JN, Srinivasula S, Hu Z, Read SW, Porter BO, Kim I, Mican JM, Paik C, Degrange P, Di Mascio M, Sereti I.

Blood. 2011 Sep 22;118(12):3244-53. doi: 10.1182/blood-2010-12-323600. Epub 2011 Jul 21.


Immunophenotype of HIV+ patients during CD4 cell-monitored treatment interruption: role of the IL-7/IL-7 receptor system.

Nemes E, Lugli E, Nasi M, Ferraresi R, Pinti M, Bugarini R, Borghi V, Prati F, Esposito R, Cossarizza A, Mussini C.

AIDS. 2006 Oct 24;20(16):2021-32.


CD127 expression and regulation are altered in the memory CD8 T cells of HIV-infected patients--reversal by highly active anti-retroviral therapy (HAART).

Colle JH, Moreau JL, Fontanet A, Lambotte O, Joussemet M, Delfraissy JF, Thèze J.

Clin Exp Immunol. 2006 Mar;143(3):398-403.


Increased plasma interleukin-7 level correlates with decreased CD127 and Increased CD132 extracellular expression on T cell subsets in patients with HIV-1 infection.

Sasson SC, Zaunders JJ, Zanetti G, King EM, Merlin KM, Smith DE, Stanley KK, Cooper DA, Kelleher AD.

J Infect Dis. 2006 Feb 15;193(4):505-14. Epub 2006 Jan 17.


Study of T cell subsets and IL-7 protein expression in HIV-1-infected patients after 7 years HAART.

Shou C, Weng N, Jin Y, Feng L, Jin C, Hoextermann S, Potthoff A, Skaletz-Rorowski A, Brockmeyer NH, Wu N.

Eur J Med Res. 2011 Nov 10;16(11):473-9.


Naive and Memory CD4⁺ T Cells Are Differentially Affected in Indonesian HIV Patients Responding to ART.

Tanaskovic S, Fernandez S, Saraswati H, Yunihastuti E, Gani RA, Djauzi S, Price P.

Viral Immunol. 2016 Apr;29(3):176-83. doi: 10.1089/vim.2015.0108.


Impaired Th17 polarization of phenotypically naive CD4(+) T-cells during chronic HIV-1 infection and potential restoration with early ART.

DaFonseca S, Niessl J, Pouvreau S, Wacleche VS, Gosselin A, Cleret-Buhot A, Bernard N, Tremblay C, Jenabian MA, Routy JP, Ancuta P.

Retrovirology. 2015 Apr 30;12:38. doi: 10.1186/s12977-015-0164-6.


Immunophenotypic patterns of CD8+ T cell subsets expressing CD8alphaalpha and IL-7Ralpha in viremic, aviremic and slow progressor HIV-1-infected subjects.

Boulassel MR, Mercier F, Gilmore N, Routy JP.

Clin Immunol. 2007 Aug;124(2):149-57. Epub 2007 Jun 11.


Decreased CD127 expression on T Cells in HIV-1-infected adults receiving antiretroviral therapy with or without intermittent IL-2 therapy.

Read SW, Higgins J, Metcalf JA, Stevens RA, Rupert A, Nason MC, Lane HC, Sereti I.

J Acquir Immune Defic Syndr. 2006 Aug 15;42(5):537-44.


Low CD4 T-cell counts despite low levels of circulating HIV: insights from the comparison of HIV-1 infected patients with a discordant response to antiretroviral therapy to patients with untreated advanced HIV-2 disease.

Albuquerque AS, Foxall RB, Cortesão CS, Soares RS, Doroana M, Ribeiro A, Lucas M, Antunes F, Victorino RM, Sousa AE.

Clin Immunol. 2007 Oct;125(1):67-75. Epub 2007 Aug 9.


Expression of the IL-7 receptor alpha-chain is down regulated on the surface of CD4 T-cells by the HIV-1 Tat protein.

McLaughlin D, Faller E, Sugden S, MacPherson P.

PLoS One. 2014 Oct 21;9(10):e111193. doi: 10.1371/journal.pone.0111193. eCollection 2014 Oct 21.


Anti-retroviral therapy in HIV-infected patients: in vitro effects of AZT and saquinavir on the response of CD4 and CD8 lymphocytes to interleukin-7.

Beq S, Bugault F, Colle JH, Lambotte O, Delfraissy JF, Thèze J.

Eur Cytokine Netw. 2005 Dec;16(4):293-9.


Central memory CD4 cells are an early indicator of immune reconstitution in HIV/AIDS patients with anti-retroviral treatment.

Hua W, Jiao Y, Zhang H, Zhang T, Chen D, Zhang Y, Chen X, Wu H.

Immunol Invest. 2012;41(1):1-14. doi: 10.3109/08820139.2011.576739. Epub 2011 May 12.


Regulatory dysfunction of the interleukin-7 receptor in CD4 and CD8 lymphocytes from HIV-infected patients--effects of antiretroviral therapy.

Colle JH, Moreau JL, Fontanet A, Lambotte O, Joussemet M, Jacod S, Delfraissy JF, Thèze J.

J Acquir Immune Defic Syndr. 2006 Jul;42(3):277-85.


T-cell homeostasis alteration in HIV-1 infected subjects with low CD4 T-cell count despite undetectable virus load during HAART.

Marziali M, De Santis W, Carello R, Leti W, Esposito A, Isgrò A, Fimiani C, Sirianni MC, Mezzaroma I, Aiuti F.

AIDS. 2006 Oct 24;20(16):2033-41.


Persistent human immunodeficiency virus-1 antigenaemia affects the expression of interleukin-7Ralpha on central and effector memory CD4+ and CD8+ T cell subsets.

Mercier F, Boulassel MR, Yassine-Diab B, Tremblay C, Bernard NF, Sekaly RP, Routy JP.

Clin Exp Immunol. 2008 Apr;152(1):72-80. doi: 10.1111/j.1365-2249.2008.03610.x. Epub 2008 Feb 14.


Inflammatory cytokines drive CD4+ T-cell cycling and impaired responsiveness to interleukin 7: implications for immune failure in HIV disease.

Shive CL, Mudd JC, Funderburg NT, Sieg SF, Kyi B, Bazdar DA, Mangioni D, Gori A, Jacobson JM, Brooks AD, Hardacre J, Ammori J, Estes JD, Schacker TW, Rodriguez B, Lederman MM.

J Infect Dis. 2014 Aug 15;210(4):619-29. doi: 10.1093/infdis/jiu125. Epub 2014 Feb 28.

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