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Metabolically regulated endoplasmic reticulum-associated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase: evidence for requirement of a geranylgeranylated protein.

Leichner GS, Avner R, Harats D, Roitelman J.

J Biol Chem. 2011 Sep 16;286(37):32150-61. doi: 10.1074/jbc.M111.278036. Epub 2011 Jul 21.


Geranylgeranyl pyrophosphate is a potent regulator of HRD-dependent 3-Hydroxy-3-methylglutaryl-CoA reductase degradation in yeast.

Garza RM, Tran PN, Hampton RY.

J Biol Chem. 2009 Dec 18;284(51):35368-80. doi: 10.1074/jbc.M109.023994.


Dislocation of HMG-CoA reductase and Insig-1, two polytopic endoplasmic reticulum proteins, en route to proteasomal degradation.

Leichner GS, Avner R, Harats D, Roitelman J.

Mol Biol Cell. 2009 Jul;20(14):3330-41. doi: 10.1091/mbc.E08-09-0953. Epub 2009 May 20.


Involvement of calcium in the mevalonate-accelerated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase.

Roitelman J, Bar-Nun S, Inoue S, Simoni RD.

J Biol Chem. 1991 Aug 25;266(24):16085-91.


The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

Ravid T, Doolman R, Avner R, Harats D, Roitelman J.

J Biol Chem. 2000 Nov 17;275(46):35840-7.


Oligomerization state influences the degradation rate of 3-hydroxy-3-methylglutaryl-CoA reductase.

Cheng HH, Xu L, Kumagai H, Simoni RD.

J Biol Chem. 1999 Jun 11;274(24):17171-8.


An oxysterol-derived positive signal for 3-hydroxy- 3-methylglutaryl-CoA reductase degradation in yeast.

Gardner RG, Shan H, Matsuda SP, Hampton RY.

J Biol Chem. 2001 Mar 23;276(12):8681-94. Epub 2000 Dec 27.


Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol.

Sever N, Song BL, Yabe D, Goldstein JL, Brown MS, DeBose-Boyd RA.

J Biol Chem. 2003 Dec 26;278(52):52479-90. Epub 2003 Oct 16.


Inhibition of degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in vivo by cysteine protease inhibitors.

Inoue S, Bar-Nun S, Roitelman J, Simoni RD.

J Biol Chem. 1991 Jul 15;266(20):13311-7.


Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast.

Theesfeld CL, Hampton RY.

J Biol Chem. 2013 Mar 22;288(12):8519-30. doi: 10.1074/jbc.M112.404517. Epub 2013 Jan 10.


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