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Protective effect of liposome-encapsulated glutathione in a human epidermal model exposed to a mustard gas analog.

Paromov V, Kumari S, Brannon M, Kanaparthy NS, Yang H, Smith MG, Stone WL.

J Toxicol. 2011;2011:109516. doi: 10.1155/2011/109516. Epub 2011 May 30.


Efficacy of glutathione in ameliorating sulfur mustard analog-induced toxicity in cultured skin epidermal cells and in SKH-1 mouse skin in vivo.

Tewari-Singh N, Agarwal C, Huang J, Day BJ, White CW, Agarwal R.

J Pharmacol Exp Ther. 2011 Feb;336(2):450-9. doi: 10.1124/jpet.110.173708. Epub 2010 Oct 25. Review.


Catalytic antioxidant AEOL 10150 treatment ameliorates sulfur mustard analog 2-chloroethyl ethyl sulfide-associated cutaneous toxic effects.

Tewari-Singh N, Inturi S, Jain AK, Agarwal C, Orlicky DJ, White CW, Agarwal R, Day BJ.

Free Radic Biol Med. 2014 Jul;72:285-95. doi: 10.1016/j.freeradbiomed.2014.04.022. Epub 2014 May 9.


Sodium pyruvate modulates cell death pathways in HaCaT keratinocytes exposed to half-mustard gas.

Paromov V, Brannon M, Kumari S, Samala M, Qui M, Smith M, Stone WL.

Int J Toxicol. 2011 Mar;30(2):197-206. doi: 10.1177/1091581810390824. Epub 2011 Feb 7.


Mechanisms of sulfur mustard analog 2-chloroethyl ethyl sulfide-induced DNA damage in skin epidermal cells and fibroblasts.

Inturi S, Tewari-Singh N, Gu M, Shrotriya S, Gomez J, Agarwal C, White CW, Agarwal R.

Free Radic Biol Med. 2011 Dec 15;51(12):2272-80. doi: 10.1016/j.freeradbiomed.2011.08.020. Epub 2011 Aug 26.


Sulfur mustard analog, 2-chloroethyl ethyl sulfide-induced skin injury involves DNA damage and induction of inflammatory mediators, in part via oxidative stress, in SKH-1 hairless mouse skin.

Jain AK, Tewari-Singh N, Gu M, Inturi S, White CW, Agarwal R.

Toxicol Lett. 2011 Sep 10;205(3):293-301. doi: 10.1016/j.toxlet.2011.06.019. Epub 2011 Jun 21.


The influence of N-acetyl-L-cysteine on oxidative stress and nitric oxide synthesis in stimulated macrophages treated with a mustard gas analogue.

Paromov V, Qui M, Yang H, Smith M, Stone WL.

BMC Cell Biol. 2008 Jun 20;9:33. doi: 10.1186/1471-2121-9-33.


Role of MAPK/AP-1 signaling pathway in the protection of CEES-induced lung injury by antioxidant liposome.

Mukhopadhyay S, Mukherjee S, Stone WL, Smith M, Das SK.

Toxicology. 2009 Jul 10;261(3):143-51. doi: 10.1016/j.tox.2009.05.010. Epub 2009 May 21.


Ameliorating effect of S-2(ω-aminoalkylamino) alkylaryl sulfide (DRDE-07) on sulfur mustard analogue, 2-chloroethyl ethyl sulfide-induced oxidative stress and inflammation.

Sawale SD, Ambhore PD, Pawar PP, Pathak U, Deb U, Satpute RM.

Toxicol Mech Methods. 2013 Nov;23(9):702-10. doi: 10.3109/15376516.2013.843109. Epub 2013 Oct 28.


Protection of half sulfur mustard gas-induced lung injury in guinea pigs by antioxidant liposomes.

Mukherjee S, Stone WL, Yang H, Smith MG, Das SK.

J Biochem Mol Toxicol. 2009 Mar-Apr;23(2):143-53. doi: 10.1002/jbt.20279.


Silibinin attenuates sulfur mustard analog-induced skin injury by targeting multiple pathways connecting oxidative stress and inflammation.

Tewari-Singh N, Jain AK, Inturi S, Agarwal C, White CW, Agarwal R.

PLoS One. 2012;7(9):e46149. doi: 10.1371/journal.pone.0046149. Epub 2012 Sep 27.


Antioxidant liposomes protect against CEES-induced lung injury by decreasing SAF-1/MAZ-mediated inflammation in the guinea pig lung.

Mukhopadhyay S, Mukherjee S, Ray BK, Ray A, Stone WL, Das SK.

J Biochem Mol Toxicol. 2010 May-Jun;24(3):187-94. doi: 10.1002/jbt.20329.


A role for mitochondrial oxidative stress in sulfur mustard analog 2-chloroethyl ethyl sulfide-induced lung cell injury and antioxidant protection.

Gould NS, White CW, Day BJ.

J Pharmacol Exp Ther. 2009 Mar;328(3):732-9. doi: 10.1124/jpet.108.145037. Epub 2008 Dec 8.


Attenuation of half sulfur mustard gas-induced acute lung injury in rats.

McClintock SD, Hoesel LM, Das SK, Till GO, Neff T, Kunkel RG, Smith MG, Ward PA.

J Appl Toxicol. 2006 Mar-Apr;26(2):126-31.


Treatment with the catalytic metalloporphyrin AEOL 10150 reduces inflammation and oxidative stress due to inhalation of the sulfur mustard analog 2-chloroethyl ethyl sulfide.

O'Neill HC, White CW, Veress LA, Hendry-Hofer TB, Loader JE, Min E, Huang J, Rancourt RC, Day BJ.

Free Radic Biol Med. 2010 May 1;48(9):1188-96. doi: 10.1016/j.freeradbiomed.2010.01.039. Epub 2010 Feb 4.


Inflammatory biomarkers of sulfur mustard analog 2-chloroethyl ethyl sulfide-induced skin injury in SKH-1 hairless mice.

Tewari-Singh N, Rana S, Gu M, Pal A, Orlicky DJ, White CW, Agarwal R.

Toxicol Sci. 2009 Mar;108(1):194-206. doi: 10.1093/toxsci/kfn261. Epub 2008 Dec 15.


Sulfur mustard toxicity following dermal exposure: role of oxidative stress, and antioxidant therapy.

Paromov V, Suntres Z, Smith M, Stone WL.

J Burns Wounds. 2007 Oct 30;7:e7.


Ability of antioxidant liposomes to prevent acute and progressive pulmonary injury.

Hoesel LM, Flierl MA, Niederbichler AD, Rittirsch D, McClintock SD, Reuben JS, Pianko MJ, Stone W, Yang H, Smith M, Sarma JV, Ward PA.

Antioxid Redox Signal. 2008 May;10(5):973-81. doi: 10.1089/ars.2007.1878.


Protection by antioxidants against toxicity and apoptosis induced by the sulphur mustard analog 2-chloroethylethyl sulphide (CEES) in Jurkat T cells and normal human lymphocytes.

Han S, Espinoza LA, Liao H, Boulares AH, Smulson ME.

Br J Pharmacol. 2004 Mar;141(5):795-802. Epub 2004 Feb 9. Erratum in: Br J Pharmacol. 2004 May;142(1):229.

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