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Items: 1 to 20 of 87

1.

A common mutation in the defensin DEFB126 causes impaired sperm function and subfertility.

Tollner TL, Venners SA, Hollox EJ, Yudin AI, Liu X, Tang G, Xing H, Kays RJ, Lau T, Overstreet JW, Xu X, Bevins CL, Cherr GN.

Sci Transl Med. 2011 Jul 20;3(92):92ra65. doi: 10.1126/scitranslmed.3002289. Erratum in: Sci Transl Med. 2011 Aug 3;(94):94er5. Sci Transl Med. 2014 May 14;6(236):236er3.

2.

Lectin binding of human sperm associates with DEFB126 mutation and serves as a potential biomarker for subfertility.

Xin A, Cheng L, Diao H, Wu Y, Zhou S, Shi C, Sun Y, Wang P, Duan S, Zheng J, Wu B, Yuan Y, Gu Y, Chen G, Sun X, Shi H, Tao S, Zhang Y.

Sci Rep. 2016 Feb 1;6:20249. doi: 10.1038/srep20249.

3.

The carbohydrate structure of DEFB126, the major component of the cynomolgus Macaque sperm plasma membrane glycocalyx.

Yudin AI, Treece CA, Tollner TL, Overstreet JW, Cherr GN.

J Membr Biol. 2005 Oct;207(3):119-29.

PMID:
16550483
4.

Defending male fertility.

Rozen S.

Sci Transl Med. 2011 Jul 20;3(92):92ps31. doi: 10.1126/scitranslmed.3002743.

PMID:
21775666
5.

Multifunctional glycoprotein DEFB126--a curious story of defensin-clad spermatozoa.

Tollner TL, Bevins CL, Cherr GN.

Nat Rev Urol. 2012 Jun 19;9(7):365-75. doi: 10.1038/nrurol.2012.109. Review.

PMID:
22710670
6.

Another functional frame-shift polymorphism of DEFB126 (rs11467497) associated with male infertility.

Duan S, Shi C, Chen G, Zheng JF, Wu B, Diao H, Ji L, Gu Y, Xin A, Wu Y, Zhou W, Miao M, Xu L, Li Z, Yuan Y, Wang P, Shi H.

J Cell Mol Med. 2015 May;19(5):1077-84. doi: 10.1111/jcmm.12502. Epub 2015 Feb 27.

7.

Cloning and characterization of a novel sperm-associated isoantigen (E-3) with defensin- and lectin-like motifs expressed in rat epididymis.

Rao J, Herr JC, Reddi PP, Wolkowicz MJ, Bush LA, Sherman NE, Black M, Flickinger CJ.

Biol Reprod. 2003 Jan;68(1):290-301.

PMID:
12493725
8.

Macaque sperm coating protein DEFB126 facilitates sperm penetration of cervical mucus.

Tollner TL, Yudin AI, Treece CA, Overstreet JW, Cherr GN.

Hum Reprod. 2008 Nov;23(11):2523-34. doi: 10.1093/humrep/den276. Epub 2008 Jul 25.

PMID:
18658160
9.

The role of DEFB126 variation in male infertility and medically assisted reproduction technique outcome.

Boroujeni PB, Ebrahimian S, Abedini M, Chayjan MR, Hassani M, Gourabi H, Sadighi-Gilani MA, Sabbaghian M, Meybodi AM.

Reprod Biomed Online. 2019 May 21. pii: S1472-6483(19)30550-4. doi: 10.1016/j.rbmo.2019.05.012. [Epub ahead of print]

PMID:
31474436
10.

BETA-DEFENSIN126 IS CORRELATED WITH SPERM MOTILITY IN FERTILE AND INFERTILE MEN.

Aram R, Chan PTK, Cyr DG.

Biol Reprod. 2019 Aug 28. pii: ioz171. doi: 10.1093/biolre/ioz171. [Epub ahead of print]

PMID:
31504198
11.

Beta-defensin 126 on the cell surface protects sperm from immunorecognition and binding of anti-sperm antibodies.

Yudin AI, Generao SE, Tollner TL, Treece CA, Overstreet JW, Cherr GN.

Biol Reprod. 2005 Dec;73(6):1243-52. Epub 2005 Aug 3.

PMID:
16079310
12.

Beta-defensin 126 on the surface of macaque sperm mediates attachment of sperm to oviductal epithelia.

Tollner TL, Yudin AI, Tarantal AF, Treece CA, Overstreet JW, Cherr GN.

Biol Reprod. 2008 Mar;78(3):400-12. Epub 2007 Nov 14.

PMID:
18003946
13.

Lipopolysaccharide-induced epididymitis disrupts epididymal beta-defensin expression and inhibits sperm motility in rats.

Cao D, Li Y, Yang R, Wang Y, Zhou Y, Diao H, Zhao Y, Zhang Y, Lu J.

Biol Reprod. 2010 Dec;83(6):1064-70. doi: 10.1095/biolreprod.109.082180. Epub 2010 Sep 8.

PMID:
20826730
14.

Human beta-defensin DEFB126 is capable of inhibiting LPS-mediated inflammation.

Liu H, Yu H, Gu Y, Xin A, Zhang Y, Diao H, Lin D.

Appl Microbiol Biotechnol. 2013 Apr;97(8):3395-408. doi: 10.1007/s00253-012-4588-9. Epub 2012 Dec 11.

PMID:
23229569
15.

Partial deletion of chromosome 8 β-defensin cluster confers sperm dysfunction and infertility in male mice.

Zhou YS, Webb S, Lettice L, Tardif S, Kilanowski F, Tyrrell C, Macpherson H, Semple F, Tennant P, Baker T, Hart A, Devenney P, Perry P, Davey T, Barran P, Barratt CL, Dorin JR.

PLoS Genet. 2013 Oct;9(10):e1003826. doi: 10.1371/journal.pgen.1003826. Epub 2013 Oct 24.

16.

Identification of a new recurrent aurora kinase C mutation in both European and African men with macrozoospermia.

Ben Khelifa M, Coutton C, Blum MG, Abada F, Harbuz R, Zouari R, Guichet A, May-Panloup P, Mitchell V, Rollet J, Triki C, Merdassi G, Vialard F, Koscinski I, Viville S, Keskes L, Soulie JP, Rives N, Dorphin B, Lestrade F, Hesters L, Poirot C, Benzacken B, Jouk PS, Satre V, Hennebicq S, Arnoult C, Lunardi J, Ray PF.

Hum Reprod. 2012 Nov;27(11):3337-46. doi: 10.1093/humrep/des296. Epub 2012 Aug 11.

PMID:
22888167
17.

CYP1A1 3801T>C polymorphism implicated in altered xenobiotic metabolism is not associated with variations in sperm production and function as measured by total motile sperm and fertilization rates with intracytoplasmic sperm injection.

Franasiak JM, Barnett R, Molinaro TA, Gabriele D, Gartmond TD, Treff NR, Scott RT.

Fertil Steril. 2016 Aug;106(2):481-6. doi: 10.1016/j.fertnstert.2016.04.003. Epub 2016 Apr 23.

PMID:
27117375
18.

Polymorphisms of β-defensin genes in Valle del Belice dairy sheep.

Monteleone G, Calascibetta D, Scaturro M, Galluzzo P, Palmeri M, Riggio V, Portolano B.

Mol Biol Rep. 2011 Nov;38(8):5405-12. doi: 10.1007/s11033-011-0694-5. Epub 2011 Mar 10.

PMID:
21390500
19.

Homozygous mutation of PLCZ1 leads to defective human oocyte activation and infertility that is not rescued by the WW-binding protein PAWP.

Escoffier J, Lee HC, Yassine S, Zouari R, Martinez G, Karaouzène T, Coutton C, Kherraf ZE, Halouani L, Triki C, Nef S, Thierry-Mieg N, Savinov SN, Fissore R, Ray PF, Arnoult C.

Hum Mol Genet. 2016 Mar 1;25(5):878-91. doi: 10.1093/hmg/ddv617. Epub 2015 Dec 31.

20.

Fertilization defects in sperm from Cysteine-rich secretory protein 2 (Crisp2) knockout mice: implications for fertility disorders.

Brukman NG, Miyata H, Torres P, Lombardo D, Caramelo JJ, Ikawa M, Da Ros VG, Cuasnicú PS.

Mol Hum Reprod. 2016 Apr;22(4):240-51. doi: 10.1093/molehr/gaw005. Epub 2016 Jan 19.

PMID:
26786179

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