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Modified cAMP derivatives: powerful tools in heart research.

Szentandrássy N, Harmati G, Farkas V, Horváth B, Hegyi B, Magyar J, Szénási G, Márton I, Nánási PP.

Curr Med Chem. 2011;18(24):3729-36.


Dopamine D1-like receptor activation depolarizes medium spiny neurons of the mouse nucleus accumbens by inhibiting inwardly rectifying K+ currents through a cAMP-dependent protein kinase A-independent mechanism.

Podda MV, Riccardi E, D'Ascenzo M, Azzena GB, Grassi C.

Neuroscience. 2010 May 19;167(3):678-90. doi: 10.1016/j.neuroscience.2010.02.075. Epub 2010 Mar 6.


Negative feedback exerted by cAMP-dependent protein kinase and cAMP phosphodiesterase on subsarcolemmal cAMP signals in intact cardiac myocytes: an in vivo study using adenovirus-mediated expression of CNG channels.

Rochais F, Vandecasteele G, Lefebvre F, Lugnier C, Lum H, Mazet JL, Cooper DM, Fischmeister R.

J Biol Chem. 2004 Dec 10;279(50):52095-105. Epub 2004 Oct 1.


Effects of β-adrenoceptor stimulation on delayed rectifier K(+) currents in canine ventricular cardiomyocytes.

Harmati G, Bányász T, Bárándi L, Szentandrássy N, Horváth B, Szabó G, Szentmiklósi JA, Szénási G, Nánási PP, Magyar J.

Br J Pharmacol. 2011 Feb;162(4):890-6. doi: 10.1111/j.1476-5381.2010.01092.x.


cAMP activates BKCa channels in pulmonary arterial smooth muscle via cGMP-dependent protein kinase.

Barman SA, Zhu S, Han G, White RE.

Am J Physiol Lung Cell Mol Physiol. 2003 Jun;284(6):L1004-11. Epub 2003 Jan 24.


Exposure to cAMP and beta-adrenergic stimulation recruits Ca(V)3 T-type channels in rat chromaffin cells through Epac cAMP-receptor proteins.

Novara M, Baldelli P, Cavallari D, Carabelli V, Giancippoli A, Carbone E.

J Physiol. 2004 Jul 15;558(Pt 2):433-49. Epub 2004 May 7.


cAMP/PKA antagonizes thrombin-induced inactivation of endothelial myosin light chain phosphatase: role of CPI-17.

Aslam M, Härtel FV, Arshad M, Gündüz D, Abdallah Y, Sauer H, Piper HM, Noll T.

Cardiovasc Res. 2010 Jul 15;87(2):375-84. doi: 10.1093/cvr/cvq065. Epub 2010 Mar 3.


Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor.

Rangarajan S, Enserink JM, Kuiperij HB, de Rooij J, Price LS, Schwede F, Bos JL.

J Cell Biol. 2003 Feb 17;160(4):487-93. Epub 2003 Feb 10.


alpha1-Adrenoceptors stimulate a Galphas protein and reduce the transient outward K+ current via a cAMP/PKA-mediated pathway in the rat heart.

Gallego M, Setién R, Puebla L, Boyano-Adánez Mdel C, Arilla E, Casis O.

Am J Physiol Cell Physiol. 2005 Mar;288(3):C577-85. Epub 2004 Oct 20.


Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation.

Mei FC, Qiao J, Tsygankova OM, Meinkoth JL, Quilliam LA, Cheng X.

J Biol Chem. 2002 Mar 29;277(13):11497-504. Epub 2002 Jan 18.


Exchange protein directly activated by cAMP mediates slow delayed-rectifier current remodeling by sustained β-adrenergic activation in guinea pig hearts.

Aflaki M, Qi XY, Xiao L, Ordog B, Tadevosyan A, Luo X, Maguy A, Shi Y, Tardif JC, Nattel S.

Circ Res. 2014 Mar 14;114(6):993-1003. doi: 10.1161/CIRCRESAHA.113.302982. Epub 2014 Feb 7.


Beta-adrenoceptor activation and PKA regulate delayed rectifier K+ channels of vascular smooth muscle cells.

Aiello EA, Malcolm AT, Walsh MP, Cole WC.

Am J Physiol. 1998 Aug;275(2 Pt 2):H448-59.


Mechanisms underlying the activation of L-type calcium channels by urocortin in rat ventricular myocytes.

Smani T, Calderón-Sanchez E, Gómez-Hurtado N, Fernández-Velasco M, Cachofeiro V, Lahera V, Ordoñez A, Delgado C.

Cardiovasc Res. 2010 Aug 1;87(3):459-66. doi: 10.1093/cvr/cvq063. Epub 2010 Feb 26.


PDE4 inhibitor, roflumilast protects cardiomyocytes against NO-induced apoptosis via activation of PKA and Epac dual pathways.

Kwak HJ, Park KM, Choi HE, Chung KS, Lim HJ, Park HY.

Cell Signal. 2008 May;20(5):803-14. doi: 10.1016/j.cellsig.2007.12.011. Epub 2007 Dec 28.


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