Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 87

1.

Dickkopf-1 regulates bone formation in young growing rodents and upon traumatic injury.

Li X, Grisanti M, Fan W, Asuncion FJ, Tan HL, Dwyer D, Han CY, Yu L, Lee J, Lee E, Barrero M, Kurimoto P, Niu QT, Geng Z, Winters A, Horan T, Steavenson S, Jacobsen F, Chen Q, Haldankar R, Lavallee J, Tipton B, Daris M, Sheng J, Lu HS, Daris K, Deshpande R, Valente EG, Salimi-Moosavi H, Kostenuik PJ, Li J, Liu M, Li C, Lacey DL, Simonet WS, Ke HZ, Babij P, Stolina M, Ominsky MS, Richards WG.

J Bone Miner Res. 2011 Nov;26(11):2610-21. doi: 10.1002/jbmr.472.

2.

Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia.

Li J, Sarosi I, Cattley RC, Pretorius J, Asuncion F, Grisanti M, Morony S, Adamu S, Geng Z, Qiu W, Kostenuik P, Lacey DL, Simonet WS, Bolon B, Qian X, Shalhoub V, Ominsky MS, Zhu Ke H, Li X, Richards WG.

Bone. 2006 Oct;39(4):754-66. Epub 2006 May 26.

PMID:
16730481
3.

The effects of Dickkopf-1 antibody on metaphyseal bone and implant fixation under different loading conditions.

Agholme F, Isaksson H, Kuhstoss S, Aspenberg P.

Bone. 2011 May 1;48(5):988-96. doi: 10.1016/j.bone.2011.02.008. Epub 2011 Feb 15.

PMID:
21329773
4.

Sclerostin and Dickkopf-1 as therapeutic targets in bone diseases.

Ke HZ, Richards WG, Li X, Ominsky MS.

Endocr Rev. 2012 Oct;33(5):747-83. doi: 10.1210/er.2011-1060. Epub 2012 Jun 20. Review.

PMID:
22723594
5.

Dkk1 haploinsufficiency requires expression of Bmp2 for bone anabolic activity.

Intini G, Nyman JS.

Bone. 2015 Jun;75:151-60. doi: 10.1016/j.bone.2015.01.008. Epub 2015 Jan 17.

6.

Generation and selection of novel fully human monoclonal antibodies that neutralize Dickkopf-1 (DKK1) inhibitory function in vitro and increase bone mass in vivo.

Glantschnig H, Hampton RA, Lu P, Zhao JZ, Vitelli S, Huang L, Haytko P, Cusick T, Ireland C, Jarantow SW, Ernst R, Wei N, Nantermet P, Scott KR, Fisher JE, Talamo F, Orsatti L, Reszka AA, Sandhu P, Kimmel D, Flores O, Strohl W, An Z, Wang F.

J Biol Chem. 2010 Dec 17;285(51):40135-47. doi: 10.1074/jbc.M110.166892. Epub 2010 Oct 7.

7.

Knocking down dickkopf-1 alleviates estrogen deficiency induction of bone loss. A histomorphological study in ovariectomized rats.

Wang FS, Ko JY, Lin CL, Wu HL, Ke HJ, Tai PJ.

Bone. 2007 Feb;40(2):485-92. Epub 2006 Oct 20.

PMID:
17055793
8.

Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass.

Morvan F, Boulukos K, Clément-Lacroix P, Roman Roman S, Suc-Royer I, Vayssière B, Ammann P, Martin P, Pinho S, Pognonec P, Mollat P, Niehrs C, Baron R, Rawadi G.

J Bone Miner Res. 2006 Jun;21(6):934-45.

9.

Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo.

Choi HY, Dieckmann M, Herz J, Niemeier A.

PLoS One. 2009 Nov 20;4(11):e7930. doi: 10.1371/journal.pone.0007930.

10.

Vaccination with DKK1-derived peptides promotes bone formation and bone mass in an aged mouse osteoporosis model.

Wu Q, Li RS, Zhao Y, Wang ZX, Tang YC, Zhang J, Liu JN, Tan XY.

Calcif Tissue Int. 2014 Aug;95(2):153-65. doi: 10.1007/s00223-014-9875-2. Epub 2014 Jun 8.

PMID:
24907907
11.

Modulation of Dickkopf-1 attenuates glucocorticoid induction of osteoblast apoptosis, adipocytic differentiation, and bone mass loss.

Wang FS, Ko JY, Yeh DW, Ke HC, Wu HL.

Endocrinology. 2008 Apr;149(4):1793-801. doi: 10.1210/en.2007-0910. Epub 2008 Jan 3.

PMID:
18174290
12.

Bone mass is inversely proportional to Dkk1 levels in mice.

MacDonald BT, Joiner DM, Oyserman SM, Sharma P, Goldstein SA, He X, Hauschka PV.

Bone. 2007 Sep;41(3):331-9. Epub 2007 Jun 5.

13.

Bovine lactoferrin improves bone mass and microstructure in ovariectomized rats via OPG/RANKL/RANK pathway.

Hou JM, Xue Y, Lin QM.

Acta Pharmacol Sin. 2012 Oct;33(10):1277-84. doi: 10.1038/aps.2012.83. Epub 2012 Aug 20.

14.

Comparison of serum Dkk1 (Dickkopf-1) and bone mineral density in patients on bisphosphonate treatment vs no treatment.

Memon AR, Butler JS, O'Riordan MV, Guerin E, Dimitrov BD, Harty JA.

J Clin Densitom. 2013 Jan-Mar;16(1):118-24. doi: 10.1016/j.jocd.2012.07.003. Epub 2012 Sep 5.

PMID:
22959779
15.

Dkk1 stabilizes Wnt co-receptor LRP6: implication for Wnt ligand-induced LRP6 down-regulation.

Li Y, Lu W, King TD, Liu CC, Bijur GN, Bu G.

PLoS One. 2010 Jun 8;5(6):e11014. doi: 10.1371/journal.pone.0011014.

16.

The relationship between inhibitors of the Wnt signalling pathway (Dickkopf-1(DKK1) and sclerostin), bone mineral density, vascular calcification and arterial stiffness in post-menopausal women.

Hampson G, Edwards S, Conroy S, Blake GM, Fogelman I, Frost ML.

Bone. 2013 Sep;56(1):42-7. doi: 10.1016/j.bone.2013.05.010. Epub 2013 May 20.

PMID:
23702386
17.

Hyperthyroidism and Hypothyroidism in Male Mice and Their Effects on Bone Mass, Bone Turnover, and the Wnt Inhibitors Sclerostin and Dickkopf-1.

Tsourdi E, Rijntjes E, Köhrle J, Hofbauer LC, Rauner M.

Endocrinology. 2015 Oct;156(10):3517-27. doi: 10.1210/en.2015-1073. Epub 2015 Jul 28.

PMID:
26218891
18.

Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo.

Yaccoby S, Ling W, Zhan F, Walker R, Barlogie B, Shaughnessy JD Jr.

Blood. 2007 Mar 1;109(5):2106-11. Epub 2006 Oct 26.

19.

Anti-DKK1 antibody promotes bone fracture healing through activation of β-catenin signaling.

Jin H, Wang B, Li J, Xie W, Mao Q, Li S, Dong F, Sun Y, Ke HZ, Babij P, Tong P, Chen D.

Bone. 2015 Feb;71:63-75. doi: 10.1016/j.bone.2014.07.039. Epub 2014 Sep 28.

20.

A rate-limiting role for Dickkopf-1 in bone formation and the remediation of bone loss in mouse and primate models of postmenopausal osteoporosis by an experimental therapeutic antibody.

Glantschnig H, Scott K, Hampton R, Wei N, McCracken P, Nantermet P, Zhao JZ, Vitelli S, Huang L, Haytko P, Lu P, Fisher JE, Sandhu P, Cook J, Williams D, Strohl W, Flores O, Kimmel D, Wang F, An Z.

J Pharmacol Exp Ther. 2011 Aug;338(2):568-78. doi: 10.1124/jpet.111.181404. Epub 2011 Apr 29.

Supplemental Content

Support Center