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Items: 1 to 20 of 66

1.

Mutant ubiquitin (UBB+1) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3).

Dennissen FJ, Kholod N, Hermes DJ, Kemmerling N, Steinbusch HW, Dantuma NP, van Leeuwen FW.

FEBS Lett. 2011 Aug 19;585(16):2568-74. doi: 10.1016/j.febslet.2011.06.037. Epub 2011 Jul 6.

2.

Disease-specific accumulation of mutant ubiquitin as a marker for proteasomal dysfunction in the brain.

Fischer DF, De Vos RA, Van Dijk R, De Vrij FM, Proper EA, Sonnemans MA, Verhage MC, Sluijs JA, Hobo B, Zouambia M, Steur EN, Kamphorst W, Hol EM, Van Leeuwen FW.

FASEB J. 2003 Nov;17(14):2014-24.

PMID:
14597671
3.

Ubiquitin dimers control the hydrolase activity of UCH-L3.

Setsuie R, Sakurai M, Sakaguchi Y, Wada K.

Neurochem Int. 2009 May-Jun;54(5-6):314-21. doi: 10.1016/j.neuint.2008.12.013. Epub 2008 Dec 25.

PMID:
19154770
4.

Characterizing substrate selectivity of ubiquitin C-terminal hydrolase-L3 using engineered α-linked ubiquitin substrates.

Navarro MF, Carmody L, Romo-Fewell O, Lokensgard ME, Love JJ.

Biochemistry. 2014 Dec 30;53(51):8031-42. doi: 10.1021/bi5006317. Epub 2014 Dec 17.

PMID:
25369561
5.

Low levels of mutant ubiquitin are degraded by the proteasome in vivo.

van Tijn P, Verhage MC, Hobo B, van Leeuwen FW, Fischer DF.

J Neurosci Res. 2010 Aug 15;88(11):2325-37. doi: 10.1002/jnr.22396.

PMID:
20336771
6.

Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation.

Lindsten K, de Vrij FM, Verhoef LG, Fischer DF, van Leeuwen FW, Hol EM, Masucci MG, Dantuma NP.

J Cell Biol. 2002 Apr 29;157(3):417-27. Epub 2002 Apr 29.

7.
8.

Dose-dependent inhibition of proteasome activity by a mutant ubiquitin associated with neurodegenerative disease.

van Tijn P, de Vrij FM, Schuurman KG, Dantuma NP, Fischer DF, van Leeuwen FW, Hol EM.

J Cell Sci. 2007 May 1;120(Pt 9):1615-23. Epub 2007 Apr 3.

9.

Mutant ubiquitin expressed in Alzheimer's disease causes neuronal death.

De Vrij FM, Sluijs JA, Gregori L, Fischer DF, Hermens WT, Goldgaber D, Verhaagen J, Van Leeuwen FW, Hol EM.

FASEB J. 2001 Dec;15(14):2680-8.

PMID:
11726544
10.

Ubiquitin C-terminal hydrolase-L3 regulates EMT process and cancer metastasis in prostate cell lines.

Song HM, Lee JE, Kim JH.

Biochem Biophys Res Commun. 2014 Sep 26;452(3):722-7. doi: 10.1016/j.bbrc.2014.08.144. Epub 2014 Sep 4.

PMID:
25194810
11.

Minimal length requirement for proteasomal degradation of ubiquitin-dependent substrates.

Verhoef LG, Heinen C, Selivanova A, Halff EF, Salomons FA, Dantuma NP.

FASEB J. 2009 Jan;23(1):123-33. doi: 10.1096/fj.08-115055. Epub 2008 Sep 16.

PMID:
18796559
12.

A sensitive fluorescence intensity assay for deubiquitinating proteases using ubiquitin-rhodamine110-glycine as substrate.

Hassiepen U, Eidhoff U, Meder G, Bulber JF, Hein A, Bodendorf U, Lorthiois E, Martoglio B.

Anal Biochem. 2007 Dec 15;371(2):201-7. Epub 2007 Aug 11.

PMID:
17869210
13.

Ubiquitin binding interface mapping on yeast ubiquitin hydrolase by NMR chemical shift perturbation.

Rajesh S, Sakamoto T, Iwamoto-Sugai M, Shibata T, Kohno T, Ito Y.

Biochemistry. 1999 Jul 20;38(29):9242-53.

PMID:
10413498
14.

Frameshift proteins in Alzheimer's disease and in other conformational disorders: time for the ubiquitin-proteasome system.

van Leeuwen FW, Hol EM, Fischer DF.

J Alzheimers Dis. 2006;9(3 Suppl):319-25. Review.

PMID:
16914870
15.

Conformational diseases: an umbrella for various neurological disorders with an impaired ubiquitin-proteasome system.

de Pril R, Fischer DF, van Leeuwen FW.

Neurobiol Aging. 2006 Apr;27(4):515-23. Epub 2005 Oct 13. Review.

PMID:
16226348
16.

The mechanism of cytokeratin aggresome formation: the role of mutant ubiquitin (UBB+1).

Bardag-Gorce F, Riley N, Nguyen V, Montgomery RO, French BA, Li J, van Leeuwen FW, Lungo W, McPhaul LW, French SW.

Exp Mol Pathol. 2003 Apr;74(2):160-7.

PMID:
12710947
17.

Locus coeruleus neurons are resistant to dysfunction and degeneration by maintaining free ubiquitin levels although total ubiquitin levels decrease upon disruption of polyubiquitin gene Ubb.

Park CW, Ryu HW, Ryu KY.

Biochem Biophys Res Commun. 2012 Feb 17;418(3):541-6. doi: 10.1016/j.bbrc.2012.01.063. Epub 2012 Jan 21.

PMID:
22285186
18.

Cleavage of the C-terminus of NEDD8 by UCH-L3.

Wada H, Kito K, Caskey LS, Yeh ET, Kamitani T.

Biochem Biophys Res Commun. 1998 Oct 29;251(3):688-92.

PMID:
9790970
20.

Long-term proteasomal inhibition in transgenic mice by UBB(+1) expression results in dysfunction of central respiration control reminiscent of brainstem neuropathology in Alzheimer patients.

Irmler M, Gentier RJ, Dennissen FJ, Schulz H, Bolle I, Hölter SM, Kallnik M, Cheng JJ, Klingenspor M, Rozman J, Ehrhardt N, Hermes DJ, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Meyer HE, Hopkins DA, Van Leeuwen FW, Beckers J.

Acta Neuropathol. 2012 Aug;124(2):187-97. doi: 10.1007/s00401-012-1003-7. Epub 2012 Jun 23.

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