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ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control.

Gatei M, Jakob B, Chen P, Kijas AW, Becherel OJ, Gueven N, Birrell G, Lee JH, Paull TT, Lerenthal Y, Fazry S, Taucher-Scholz G, Kalb R, Schindler D, Waltes R, Dörk T, Lavin MF.

J Biol Chem. 2011 Sep 9;286(36):31542-56. doi: 10.1074/jbc.M111.258152. Epub 2011 Jul 14.


Autophosphorylation and ATM activation: additional sites add to the complexity.

Kozlov SV, Graham ME, Jakob B, Tobias F, Kijas AW, Tanuji M, Chen P, Robinson PJ, Taucher-Scholz G, Suzuki K, So S, Chen D, Lavin MF.

J Biol Chem. 2011 Mar 18;286(11):9107-19. doi: 10.1074/jbc.M110.204065. Epub 2010 Dec 13.


Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder.

Waltes R, Kalb R, Gatei M, Kijas AW, Stumm M, Sobeck A, Wieland B, Varon R, Lerenthal Y, Lavin MF, Schindler D, Dörk T.

Am J Hum Genet. 2009 May;84(5):605-16. doi: 10.1016/j.ajhg.2009.04.010. Epub 2009 Apr 30.


Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.

Cerosaletti K, Concannon P.

J Biol Chem. 2004 Sep 10;279(37):38813-9. Epub 2004 Jul 1.


Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.

Takemura H, Rao VA, Sordet O, Furuta T, Miao ZH, Meng L, Zhang H, Pommier Y.

J Biol Chem. 2006 Oct 13;281(41):30814-23. Epub 2006 Aug 10.


The Mre11/Rad50/Nbs1 complex and its role as a DNA double-strand break sensor for ATM.

Paull TT, Lee JH.

Cell Cycle. 2005 Jun;4(6):737-40. Epub 2005 Jun 6.


Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.

Lee JH, Mand MR, Deshpande RA, Kinoshita E, Yang SH, Wyman C, Paull TT.

J Biol Chem. 2013 May 3;288(18):12840-51. doi: 10.1074/jbc.M113.460378. Epub 2013 Mar 22.


The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor.

Morales M, Theunissen JW, Kim CF, Kitagawa R, Kastan MB, Petrini JH.

Genes Dev. 2005 Dec 15;19(24):3043-54.


Cleavage of the BRCT tandem domains of nibrin by the 657del5 mutation affects the DNA damage response less than the Arg215Trp mutation.

Mendez G, Cilli D, Berardinelli F, Viganotti M, Ascenzi P, Tanzarella C, Antoccia A, di Masi A.

IUBMB Life. 2012 Oct;64(10):853-61. doi: 10.1002/iub.1077. Epub 2012 Sep 3.


Rad50 depletion impacts upon ATR-dependent DNA damage responses.

Zhong H, Bryson A, Eckersdorff M, Ferguson DO.

Hum Mol Genet. 2005 Sep 15;14(18):2685-93. Epub 2005 Aug 8.


NBN phosphorylation regulates the accumulation of MRN and ATM at sites of DNA double-strand breaks.

Wen J, Cerosaletti K, Schultz KJ, Wright JA, Concannon P.

Oncogene. 2013 Sep 12;32(37):4448-56. doi: 10.1038/onc.2012.443. Epub 2012 Nov 12.


ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex.

Lee JH, Paull TT.

Science. 2005 Apr 22;308(5721):551-4. Epub 2005 Mar 24. Erratum in: Science. 2005 Jun 24;308(5730):1870.


Multiple roles for MRE11 at uncapped telomeres.

Deng Y, Guo X, Ferguson DO, Chang S.

Nature. 2009 Aug 13;460(7257):914-8. doi: 10.1038/nature08196. Epub 2009 Jul 26.


Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis.

Taylor AM, Groom A, Byrd PJ.

DNA Repair (Amst). 2004 Aug-Sep;3(8-9):1219-25. Review.


Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells.

Tomimatsu N, Mukherjee B, Burma S.

EMBO Rep. 2009 Jun;10(6):629-35. doi: 10.1038/embor.2009.60. Epub 2009 May 15.


Active role for nibrin in the kinetics of atm activation.

Cerosaletti K, Wright J, Concannon P.

Mol Cell Biol. 2006 Mar;26(5):1691-9.


Activation and regulation of ATM kinase activity in response to DNA double-strand breaks.

Lee JH, Paull TT.

Oncogene. 2007 Dec 10;26(56):7741-8. Review.


Molecular basis of ataxia telangiectasia and related diseases.

Ball LG, Xiao W.

Acta Pharmacol Sin. 2005 Aug;26(8):897-907. Review.


The ATM-dependent DNA damage signaling pathway.

Kitagawa R, Kastan MB.

Cold Spring Harb Symp Quant Biol. 2005;70:99-109. Review.


Involvement of novel autophosphorylation sites in ATM activation.

Kozlov SV, Graham ME, Peng C, Chen P, Robinson PJ, Lavin MF.

EMBO J. 2006 Aug 9;25(15):3504-14. Epub 2006 Jul 13.

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