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Items: 1 to 20 of 147

1.

Loss of AML1/Runx1 accelerates the development of MLL-ENL leukemia through down-regulation of p19ARF.

Nishimoto N, Arai S, Ichikawa M, Nakagawa M, Goyama S, Kumano K, Takahashi T, Kamikubo Y, Imai Y, Kurokawa M.

Blood. 2011 Sep 1;118(9):2541-50. doi: 10.1182/blood-2010-10-315440. Epub 2011 Jul 14.

2.

Homing and invasiveness of MLL/ENL leukemic cells is regulated by MEF2C.

Schwieger M, Schüler A, Forster M, Engelmann A, Arnold MA, Delwel R, Valk PJ, Löhler J, Slany RK, Olson EN, Stocking C.

Blood. 2009 Sep 17;114(12):2476-88. doi: 10.1182/blood-2008-05-158196. Epub 2009 Jul 7.

3.

A distinct epigenetic signature at targets of a leukemia protein.

Rossetti S, Hoogeveen AT, Liang P, Stanciu C, van der Spek P, Sacchi N.

BMC Genomics. 2007 Feb 1;8:38.

4.

Aberrant transcriptional regulation of the MLL fusion partner EEN by AML1-ETO and its implication in leukemogenesis.

Ma LH, Liu H, Xiong H, Chen B, Zhang XW, Wang YY, Le HY, Huang QH, Zhang QH, Li BL, Chen Z, Chen SJ.

Blood. 2007 Jan 15;109(2):769-77. Epub 2006 Sep 21.

5.

Differential requirement for wild-type Flt3 in leukemia initiation among mouse models of human leukemia.

Kamezaki K, Luchsinger LL, Snoeck HW.

Exp Hematol. 2014 Mar;42(3):192-203.e1. doi: 10.1016/j.exphem.2013.11.008. Epub 2013 Nov 20.

6.

Bone marrow mesenchymal stem cells from infants with MLL-AF4+ acute leukemia harbor and express the MLL-AF4 fusion gene.

Menendez P, Catalina P, Rodríguez R, Melen GJ, Bueno C, Arriero M, García-Sánchez F, Lassaletta A, García-Sanz R, García-Castro J.

J Exp Med. 2009 Dec 21;206(13):3131-41. doi: 10.1084/jem.20091050. Epub 2009 Dec 7.

7.

Acute myeloid leukemia induced by MLL-ENL is cured by oncogene ablation despite acquisition of complex genetic abnormalities.

Horton SJ, Walf-Vorderwülbecke V, Chatters SJ, Sebire NJ, de Boer J, Williams O.

Blood. 2009 May 14;113(20):4922-9. doi: 10.1182/blood-2008-07-170480. Epub 2008 Nov 24.

8.

AML1 interconnected pathways of leukemogenesis.

Michaud J, Scott HS, Escher R.

Cancer Invest. 2003;21(1):105-36. Review. Erratum in: Cancer Invest. 2003;21(4):659.

PMID:
12643014
9.

Evi-1 is a transcriptional target of mixed-lineage leukemia oncoproteins in hematopoietic stem cells.

Arai S, Yoshimi A, Shimabe M, Ichikawa M, Nakagawa M, Imai Y, Goyama S, Kurokawa M.

Blood. 2011 Jun 9;117(23):6304-14. doi: 10.1182/blood-2009-07-234310. Epub 2010 Dec 29.

10.

The AML1 gene: a transcription factor involved in the pathogenesis of myeloid and lymphoid leukemias.

Lo Coco F, Pisegna S, Diverio D.

Haematologica. 1997 May-Jun;82(3):364-70. Review.

11.

Clinical outcome and monitoring of minimal residual disease in patients with acute lymphoblastic leukemia expressing the MLL/ENL fusion gene.

Elia L, Grammatico S, Paoloni F, Vignetti M, Rago A, Cenfra N, Mecarocci S, Mancini M, Luciani M, Di Raimondo F, Cazzaniga G, Matarazzo M, Moleti ML, Santoro L, Gaidano G, Foà R, Mandelli F, Cimino G.

Am J Hematol. 2011 Dec;86(12):993-7. doi: 10.1002/ajh.22161. Epub 2011 Sep 22.

12.

AML1-Evi-1 specifically transforms hematopoietic stem cells through fusion of the entire Evi-1 sequence to AML1.

Takeshita M, Ichikawa M, Nitta E, Goyama S, Asai T, Ogawa S, Chiba S, Kurokawa M.

Leukemia. 2008 Jun;22(6):1241-9. doi: 10.1038/leu.2008.53. Epub 2008 Mar 13.

PMID:
18337762
13.

TEL-AML1, expressed from t(12;21) in human acute lymphocytic leukemia, induces acute leukemia in mice.

Bernardin F, Yang Y, Cleaves R, Zahurak M, Cheng L, Civin CI, Friedman AD.

Cancer Res. 2002 Jul 15;62(14):3904-8.

14.

MLL-ENL causes a reversible and myc-dependent block of myelomonocytic cell differentiation.

Schreiner S, Birke M, García-Cuéllar MP, Zilles O, Greil J, Slany RK.

Cancer Res. 2001 Sep 1;61(17):6480-6.

15.

AML1/RUNX1 functions as a cytoplasmic attenuator of NF-κB signaling in the repression of myeloid tumors.

Nakagawa M, Shimabe M, Watanabe-Okochi N, Arai S, Yoshimi A, Shinohara A, Nishimoto N, Kataoka K, Sato T, Kumano K, Nannya Y, Ichikawa M, Imai Y, Kurokawa M.

Blood. 2011 Dec 15;118(25):6626-37. doi: 10.1182/blood-2010-12-326710. Epub 2011 Oct 21.

16.

Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal.

Zhao X, Chen A, Yan X, Zhang Y, He F, Hayashi Y, Dong Y, Rao Y, Li B, Conway RM, Maiques-Diaz A, Elf SE, Huang N, Zuber J, Xiao Z, Tse W, Tenen DG, Wang Q, Chen W, Mulloy JC, Nimer SD, Huang G.

Blood. 2014 Mar 13;123(11):1729-38. doi: 10.1182/blood-2013-03-489575. Epub 2014 Jan 21.

17.

p27kip1 maintains a subset of leukemia stem cells in the quiescent state in murine MLL-leukemia.

Zhang J, Seet CS, Sun C, Li J, You D, Volk A, Breslin P, Li X, Wei W, Qian Z, Zeleznik-Le NJ, Zhang Z, Zhang J.

Mol Oncol. 2013 Dec;7(6):1069-82. doi: 10.1016/j.molonc.2013.07.011. Epub 2013 Aug 20.

18.

Persistence of multipotent progenitors expressing AML1/ETO transcripts in long-term remission patients with t(8;21) acute myelogenous leukemia.

Miyamoto T, Nagafuji K, Akashi K, Harada M, Kyo T, Akashi T, Takenaka K, Mizuno S, Gondo H, Okamura T, Dohy H, Niho Y.

Blood. 1996 Jun 1;87(11):4789-96.

19.

Targeting MLL-AF4 with short interfering RNAs inhibits clonogenicity and engraftment of t(4;11)-positive human leukemic cells.

Thomas M, Gessner A, Vornlocher HP, Hadwiger P, Greil J, Heidenreich O.

Blood. 2005 Nov 15;106(10):3559-66. Epub 2005 Jul 26.

20.

AML1-ETO rapidly induces acute myeloblastic leukemia in cooperation with the Wilms tumor gene, WT1.

Nishida S, Hosen N, Shirakata T, Kanato K, Yanagihara M, Nakatsuka S, Hoshida Y, Nakazawa T, Harada Y, Tatsumi N, Tsuboi A, Kawakami M, Oka Y, Oji Y, Aozasa K, Kawase I, Sugiyama H.

Blood. 2006 Apr 15;107(8):3303-12. Epub 2005 Dec 27.

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