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Items: 1 to 20 of 108

1.

Deoxynucleoside salvage facilitates DNA repair during ribonucleotide reductase blockade in human cervical cancers.

Kunos CA, Ferris G, Pyatka N, Pink J, Radivoyevitch T.

Radiat Res. 2011 Oct;176(4):425-33. Epub 2011 Jul 14.

2.

Ribonucleotide reductase inhibition enhances chemoradiosensitivity of human cervical cancers.

Kunos CA, Radivoyevitch T, Pink J, Chiu SM, Stefan T, Jacobberger J, Kinsella TJ.

Radiat Res. 2010 Nov;174(5):574-81. doi: 10.1667/RR2273.1. Epub 2010 Sep 10.

3.

Radiosensitization of human cervical cancer cells by inhibiting ribonucleotide reductase: enhanced radiation response at low-dose rates.

Kunos CA, Colussi VC, Pink J, Radivoyevitch T, Oleinick NL.

Int J Radiat Oncol Biol Phys. 2011 Jul 15;80(4):1198-204. doi: 10.1016/j.ijrobp.2011.01.034. Epub 2011 Apr 4.

4.

Modulating radiation resistance by inhibiting ribonucleotide reductase in cancers with virally or mutationally silenced p53 protein.

Kunos CA, Chiu SM, Pink J, Kinsella TJ.

Radiat Res. 2009 Dec;172(6):666-76. doi: 10.1667/RR1858.1.

6.

Inhibitors of ribonucleotide reductase. Comparative effects of amino- and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones.

Cory JG, Cory AH, Rappa G, Lorico A, Liu MC, Lin TS, Sartorelli AC.

Biochem Pharmacol. 1994 Jul 19;48(2):335-44.

PMID:
8053929
8.

Purine and pyrimidine metabolism in human T lymphocytes. Regulation of deoxyribonucleotide metabolism.

Cohen A, Barankiewicz J, Lederman HM, Gelfand EW.

J Biol Chem. 1983 Oct 25;258(20):12334-40.

9.

Ribonucleotide reductase inhibition restores platinum-sensitivity in platinum-resistant ovarian cancer: a Gynecologic Oncology Group Study.

Kunos C, Radivoyevitch T, Abdul-Karim FW, Fanning J, Abulafia O, Bonebrake AJ, Usha L.

J Transl Med. 2012 Apr 27;10:79. doi: 10.1186/1479-5876-10-79.

10.

Cellular regulation of ribonucleotide reductase in eukaryotes.

Guarino E, Salguero I, Kearsey SE.

Semin Cell Dev Biol. 2014 Jun;30:97-103. doi: 10.1016/j.semcdb.2014.03.030. Epub 2014 Apr 2. Review.

PMID:
24704278
11.

Theoretical study on the inhibition of ribonucleotide reductase by 2'-mercapto-2'-deoxyribonucleoside-5'-diphosphates.

Pereira S, Fernandes PA, Ramos MJ.

J Am Chem Soc. 2005 Apr 13;127(14):5174-9.

PMID:
15810852
12.

A novel assay revealed that ribonucleotide reductase is functionally important for interstrand DNA crosslink repair.

Fujii N, Evison BJ, Actis ML, Inoue A.

Bioorg Med Chem. 2015 Nov 1;23(21):6912-21. doi: 10.1016/j.bmc.2015.09.045. Epub 2015 Sep 30.

13.

Caspase-dependent Proteolysis of Human Ribonucleotide Reductase Small Subunits R2 and p53R2 during Apoptosis.

Tebbi A, Guittet O, Tuphile K, CabriƩ A, Lepoivre M.

J Biol Chem. 2015 May 29;290(22):14077-90. doi: 10.1074/jbc.M115.649640. Epub 2015 Apr 15.

14.

Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies.

Aye Y, Li M, Long MJ, Weiss RS.

Oncogene. 2015 Apr 16;34(16):2011-21. doi: 10.1038/onc.2014.155. Epub 2014 Jun 9. Review.

PMID:
24909171
15.

Effects of deoxynucleosides on cultured human leukemia cell growth and deoxynucleotide pools.

Ross DD, Akman SA, Schrecker AW, Bachur NR.

Cancer Res. 1981 Nov;41(11 Pt 1):4493-8.

16.

Triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity.

Finch RA, Liu M, Grill SP, Rose WC, Loomis R, Vasquez KM, Cheng Y, Sartorelli AC.

Biochem Pharmacol. 2000 Apr 15;59(8):983-91.

PMID:
10692563
17.

dNTP deficiency induced by HU via inhibiting ribonucleotide reductase affects neural tube development.

Guan Z, Wang X, Dong Y, Xu L, Zhu Z, Wang J, Zhang T, Niu B.

Toxicology. 2015 Feb 3;328:142-51. doi: 10.1016/j.tox.2014.12.001. Epub 2014 Dec 17.

PMID:
25527867
18.
20.

Elevated ribonucleotide reductase levels associate with suppressed radiochemotherapy response in human cervical cancers.

Kunos CA, Radivoyevitch T, Kresak A, Dawson D, Jacobberger J, Yang B, Abdul-Karim FW.

Int J Gynecol Cancer. 2012 Nov;22(9):1463-9. doi: 10.1097/IGC.0b013e318270577f.

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