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Items: 1 to 20 of 73

1.

Mono-, di- and trisubstituted derivatives of eflornithine: synthesis for in vivo delivery of DL-alpha-difluoromethylornithine in plasma.

Cloete TT, Johansson CC, N'Da DD, Vodnala SK, Rottenberg ME, Breytenbach JC, Ashton M.

Arzneimittelforschung. 2011;61(5):317-25. doi: 10.1055/s-0031-1296205.

PMID:
21755816
2.

Effects of oral administration of synthesized delta-amides of eflornithine in the rat.

Helena KJ, N'Da DD, Johansson CC, Breytenbach JC, Ashton M.

Arzneimittelforschung. 2010;60(11):682-8. doi: 10.1055/s-0031-1296347.

PMID:
21175041
4.

Differential susceptibility to DL-alpha-difluoromethylornithine in clinical isolates of Trypanosoma brucei rhodesiense.

Bacchi CJ, Nathan HC, Livingston T, Valladares G, Saric M, Sayer PD, Njogu AR, Clarkson AB Jr.

Antimicrob Agents Chemother. 1990 Jun;34(6):1183-8.

5.

Enantioselective and nonlinear intestinal absorption of eflornithine in the rat.

Jansson R, Malm M, Roth C, Ashton M.

Antimicrob Agents Chemother. 2008 Aug;52(8):2842-8. doi: 10.1128/AAC.00050-08. Epub 2008 Jun 2.

6.

The pharmacokinetics of eflornithine (alpha-difluoromethylornithine) in patients with late-stage T.b. gambiense sleeping sickness.

Na-Bangchang K, Doua F, Konsil J, Hanpitakpong W, Kamanikom B, Kuzoe F.

Eur J Clin Pharmacol. 2004 Jun;60(4):269-78. Epub 2004 May 13.

PMID:
15141331
8.
9.

In vivo effects of alpha-DL-difluoromethylornithine on the metabolism and morphology of Trypanosoma brucei brucei.

Bacchi CJ, Garofalo J, Mockenhaupt D, McCann PP, Diekema KA, Pegg AE, Nathan HC, Mullaney EA, Chunosoff L, Sjoerdsma A, Hutner SH.

Mol Biochem Parasitol. 1983 Mar;7(3):209-25.

PMID:
6193423
10.
12.

In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei.

Fairlamb AH, Henderson GB, Bacchi CJ, Cerami A.

Mol Biochem Parasitol. 1987 Jun;24(2):185-91.

PMID:
3114634
13.

Targeted delivery of compounds to Trypanosoma brucei using the melamine motif.

Chollet C, Baliani A, Wong PE, Barrett MP, Gilbert IH.

Bioorg Med Chem. 2009 Mar 15;17(6):2512-23. doi: 10.1016/j.bmc.2009.01.058. Epub 2009 Jan 31.

PMID:
19250832
14.
15.

Eflornithine. A new drug in the treatment of sleeping sickness.

Van Bogaert I, Haemers A.

Pharm Weekbl Sci. 1989 Jun 23;11(3):69-75. Review.

PMID:
2505225
16.
17.

Polyamine metabolism: a potential therapeutic target in trypanosomes.

Bacchi CJ, Nathan HC, Hutner SH, McCann PP, Sjoerdsma A.

Science. 1980 Oct 17;210(4467):332-4.

PMID:
6775372
18.
19.

Drug resistance in human African trypanosomiasis.

Barrett MP, Vincent IM, Burchmore RJ, Kazibwe AJ, Matovu E.

Future Microbiol. 2011 Sep;6(9):1037-47. doi: 10.2217/fmb.11.88. Review.

PMID:
21958143
20.

Antagonism by polyamines of the curative effects of alpha-difluoromethylornithine in Trypanosoma brucei brucei infections.

Nathan HC, Bacchi CJ, Hutner SH, Rescigno D, McCann PP, Sjoerdsma A.

Biochem Pharmacol. 1981 Nov 1;30(21):3010-3. No abstract available.

PMID:
6797437

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