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Novel inhibitors of surface layer processing in Clostridium difficile.

Tam Dang TH, Fagan RP, Fairweather NF, Tate EW.

Bioorg Med Chem. 2012 Jan 15;20(2):614-21. doi: 10.1016/j.bmc.2011.06.042. Epub 2011 Jun 21.


Chemical probes of surface layer biogenesis in Clostridium difficile.

Dang TH, de la Riva L, Fagan RP, Storck EM, Heal WP, Janoir C, Fairweather NF, Tate EW.

ACS Chem Biol. 2010 Mar 19;5(3):279-85. doi: 10.1021/cb9002859.


Modulation of the Surface-Layer Protein of Clostridium difficile through Cwp84 Inhibition.

Gooyit MD, Janda KD.

ACS Infect Dis. 2016 Jul 8;2(7):465-70. doi: 10.1021/acsinfecdis.6b00061. Epub 2016 May 31.


Cwp84, a Clostridium difficile cysteine protease, exhibits conformational flexibility in the absence of its propeptide.

Bradshaw WJ, Roberts AK, Shone CC, Acharya KR.

Acta Crystallogr F Struct Biol Commun. 2015 Mar;71(Pt 3):295-303. doi: 10.1107/S2053230X15001065. Epub 2015 Feb 19.


Cwp84, a surface-associated cysteine protease, plays a role in the maturation of the surface layer of Clostridium difficile.

Kirby JM, Ahern H, Roberts AK, Kumar V, Freeman Z, Acharya KR, Shone CC.

J Biol Chem. 2009 Dec 11;284(50):34666-73. doi: 10.1074/jbc.M109.051177. Epub 2009 Oct 6.


Cwp84, a surface-associated protein of Clostridium difficile, is a cysteine protease with degrading activity on extracellular matrix proteins.

Janoir C, Péchiné S, Grosdidier C, Collignon A.

J Bacteriol. 2007 Oct;189(20):7174-80. Epub 2007 Aug 10.


Roles of cysteine proteases Cwp84 and Cwp13 in biogenesis of the cell wall of Clostridium difficile.

de la Riva L, Willing SE, Tate EW, Fairweather NF.

J Bacteriol. 2011 Jul;193(13):3276-85. doi: 10.1128/JB.00248-11. Epub 2011 Apr 29.


The structure of the cysteine protease and lectin-like domains of Cwp84, a surface layer-associated protein from Clostridium difficile.

Bradshaw WJ, Kirby JM, Thiyagarajan N, Chambers CJ, Davies AH, Roberts AK, Shone CC, Acharya KR.

Acta Crystallogr D Biol Crystallogr. 2014 Jul;70(Pt 7):1983-93. doi: 10.1107/S1399004714009997. Epub 2014 Jun 29.


Localization of the Clostridium difficile cysteine protease Cwp84 and insights into its maturation process.

ChapetónMontes D, Candela T, Collignon A, Janoir C.

J Bacteriol. 2011 Oct;193(19):5314-21. doi: 10.1128/JB.00326-11. Epub 2011 Jul 22.


[Characterization of an extracellular protease from Clostridium difficile].

Janoir C, Grénery J, Savariau-Lacomme MP, Collignon A.

Pathol Biol (Paris). 2004 Oct;52(8):444-9. French.


Surface-layer protein A (SlpA) is a major contributor to host-cell adherence of Clostridium difficile.

Merrigan MM, Venugopal A, Roxas JL, Anwar F, Mallozzi MJ, Roxas BA, Gerding DN, Viswanathan VK, Vedantam G.

PLoS One. 2013 Nov 12;8(11):e78404. doi: 10.1371/journal.pone.0078404. eCollection 2013.


The Clostridium difficile Protease Cwp84 Modulates both Biofilm Formation and Cell-Surface Properties.

Pantaléon V, Soavelomandroso AP, Bouttier S, Briandet R, Roxas B, Chu M, Collignon A, Janoir C, Vedantam G, Candela T.

PLoS One. 2015 Apr 29;10(4):e0124971. doi: 10.1371/journal.pone.0124971. eCollection 2015.


Immunization of hamsters against Clostridium difficile infection using the Cwp84 protease as an antigen.

Péchiné S, Denève C, Le Monnier A, Hoys S, Janoir C, Collignon A.

FEMS Immunol Med Microbiol. 2011 Oct;63(1):73-81. doi: 10.1111/j.1574-695X.2011.00832.x. Epub 2011 Jul 20.


Effects of subinhibitory concentrations of antibiotics on colonization factor expression by moxifloxacin-susceptible and moxifloxacin-resistant Clostridium difficile strains.

Denève C, Bouttier S, Dupuy B, Barbut F, Collignon A, Janoir C.

Antimicrob Agents Chemother. 2009 Dec;53(12):5155-62. doi: 10.1128/AAC.00532-09. Epub 2009 Oct 5.


Transcription and analysis of polymorphism in a cluster of genes encoding surface-associated proteins of Clostridium difficile.

Savariau-Lacomme MP, Lebarbier C, Karjalainen T, Collignon A, Janoir C.

J Bacteriol. 2003 Aug;185(15):4461-70.


Synthesis of novel peptidomimetics as inhibitors of protozoan cysteine proteases falcipain-2 and rhodesain.

Ettari R, Zappalà M, Micale N, Schirmeister T, Gelhaus C, Leippe M, Evers A, Grasso S.

Eur J Med Chem. 2010 Jul;45(7):3228-33. doi: 10.1016/j.ejmech.2010.04.003. Epub 2010 Apr 14.


Influence of environmental conditions on the expression and the maturation process of the Clostridium difficile surface associated protease Cwp84.

Chapetón Montes D, Collignon A, Janoir C.

Anaerobe. 2013 Feb;19:79-82. doi: 10.1016/j.anaerobe.2012.12.004. Epub 2012 Dec 17.


Design and synthesis of irreversible depsipeptidyl human rhinovirus 3C protease inhibitors.

Webber SE, Marakovits JT, Dragovich PS, Prins TJ, Zhou R, Fuhrman SA, Patick AK, Matthews DA, Lee CA, Srinivasan B, Moran T, Ford CE, Brothers MA, Harr JE, Meador JW 3rd, Ferre RA, Worland ST.

Bioorg Med Chem Lett. 2001 Oct 22;11(20):2683-6.


Rational design of inhibitors and activity-based probes targeting Clostridium difficile virulence factor TcdB.

Puri AW, Lupardus PJ, Deu E, Albrow VE, Garcia KC, Bogyo M, Shen A.

Chem Biol. 2010 Nov 24;17(11):1201-11. doi: 10.1016/j.chembiol.2010.09.011.


Immunogenic properties of the surface layer precursor of Clostridium difficile and vaccination assays in animal models.

Bruxelle JF, Mizrahi A, Hoys S, Collignon A, Janoir C, Péchiné S.

Anaerobe. 2016 Feb;37:78-84. doi: 10.1016/j.anaerobe.2015.10.010. Epub 2015 Oct 24.


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