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Items: 1 to 20 of 271

1.

Structural basis for the regulation of cysteine-protease activity by a new class of protease inhibitors in Plasmodium.

Hansen G, Heitmann A, Witt T, Li H, Jiang H, Shen X, Heussler VT, Rennenberg A, Hilgenfeld R.

Structure. 2011 Jul 13;19(7):919-29. doi: 10.1016/j.str.2011.03.025.

2.

Exoerythrocytic Plasmodium parasites secrete a cysteine protease inhibitor involved in sporozoite invasion and capable of blocking cell death of host hepatocytes.

Rennenberg A, Lehmann C, Heitmann A, Witt T, Hansen G, Nagarajan K, Deschermeier C, Turk V, Hilgenfeld R, Heussler VT.

PLoS Pathog. 2010 Mar 26;6(3):e1000825. doi: 10.1371/journal.ppat.1000825.

3.

The impact of whole genome sequence data on drug discovery--a malaria case study.

Joachimiak MP, Chang C, Rosenthal PJ, Cohen FE.

Mol Med. 2001 Oct;7(10):698-710.

4.

Crystal structure of the parasite protease inhibitor chagasin in complex with a host target cysteine protease.

Ljunggren A, Redzynia I, Alvarez-Fernandez M, Abrahamson M, Mort JS, Krupa JC, Jaskolski M, Bujacz G.

J Mol Biol. 2007 Aug 3;371(1):137-53. Epub 2007 May 10.

PMID:
17561110
5.

The macromolecular complex of ICP and falcipain-2 from Plasmodium: preparation, crystallization and preliminary X-ray diffraction analysis.

Hansen G, Schwarzloh B, Rennenberg A, Heussler VT, Hilgenfeld R.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Nov 1;67(Pt 11):1406-10. doi: 10.1107/S1744309111034592. Epub 2011 Oct 27.

6.

Structural insights into the protease-like antigen Plasmodium falciparum SERA5 and its noncanonical active-site serine.

Hodder AN, Malby RL, Clarke OB, Fairlie WD, Colman PM, Crabb BS, Smith BJ.

J Mol Biol. 2009 Sep 11;392(1):154-65. doi: 10.1016/j.jmb.2009.07.007. Epub 2009 Jul 8.

PMID:
19591843
7.

Crystal structure of the parasite inhibitor chagasin in complex with papain allows identification of structural requirements for broad reactivity and specificity determinants for target proteases.

Redzynia I, Ljunggren A, Bujacz A, Abrahamson M, Jaskolski M, Bujacz G.

FEBS J. 2009 Feb;276(3):793-806. doi: 10.1111/j.1742-4658.2008.06824.x.

8.

Independent intramolecular mediators of folding, activity, and inhibition for the Plasmodium falciparum cysteine protease falcipain-2.

Pandey KC, Sijwali PS, Singh A, Na BK, Rosenthal PJ.

J Biol Chem. 2004 Jan 30;279(5):3484-91. Epub 2003 Nov 18.

9.

Cysteine proteases of malaria parasites.

Rosenthal PJ.

Int J Parasitol. 2004 Dec;34(13-14):1489-99. Review.

PMID:
15582526
10.

Crystal structure of chagasin, the endogenous cysteine-protease inhibitor from Trypanosoma cruzi.

Figueiredo da Silva AA, de Carvalho Vieira L, Krieger MA, Goldenberg S, Zanchin NI, Guimarães BG.

J Struct Biol. 2007 Feb;157(2):416-23. Epub 2006 Aug 17.

PMID:
17011790
11.

Crystal structure of the cysteine protease inhibitor 2 from Entamoeba histolytica: functional convergence of a common protein fold.

Casados-Vázquez LE, Lara-González S, Brieba LG.

Gene. 2011 Jan 15;471(1-2):45-52. doi: 10.1016/j.gene.2010.10.006. Epub 2010 Oct 15.

PMID:
20951777
12.

Enzymic, phylogenetic, and structural characterization of the unusual papain-like protease domain of Plasmodium falciparum SERA5.

Hodder AN, Drew DR, Epa VC, Delorenzi M, Bourgon R, Miller SK, Moritz RL, Frecklington DF, Simpson RJ, Speed TP, Pike RN, Crabb BS.

J Biol Chem. 2003 Nov 28;278(48):48169-77. Epub 2003 Sep 17.

13.

Structural and functional characterization of Falcipain-2, a hemoglobinase from the malarial parasite Plasmodium falciparum.

Hogg T, Nagarajan K, Herzberg S, Chen L, Shen X, Jiang H, Wecke M, Blohmke C, Hilgenfeld R, Schmidt CL.

J Biol Chem. 2006 Sep 1;281(35):25425-37. Epub 2006 Jun 15.

14.

A chimeric cysteine protease of Plasmodium berghei engineered to resemble the Plasmodium falciparum protease falcipain-2.

Singh A, Walker KJ, Sijwali PS, Lau AL, Rosenthal PJ.

Protein Eng Des Sel. 2007 Apr;20(4):171-7. Epub 2007 Apr 12.

PMID:
17430972
15.

Solution structure and backbone dynamics of the Trypanosoma cruzi cysteine protease inhibitor chagasin.

Salmon D, do Aido-Machado R, Diehl A, Leidert M, Schmetzer O, de A Lima AP, Scharfstein J, Oschkinat H, Pires JR.

J Mol Biol. 2006 Apr 14;357(5):1511-21. Epub 2006 Feb 3.

PMID:
16490204
16.

Exploring the role of putative active site amino acids and pro-region motif of recombinant falcipain-2: a principal hemoglobinase of Plasmodium falciparum.

Kumar A, Dasaradhi PV, Chauhan VS, Malhotra P.

Biochem Biophys Res Commun. 2004 Apr 23;317(1):38-45.

PMID:
15047145
17.

Evaluation of cysteine proteases of Plasmodium vivax as antimalarial drug targets: sequence analysis and sensitivity to cysteine protease inhibitors.

Na BK, Kim TS, Rosenthal PJ, Lee JK, Kong Y.

Parasitol Res. 2004 Oct;94(4):312-7. Epub 2004 Sep 15.

PMID:
15372231
18.

Plasmodium falciparum: biochemical characterization of the cysteine protease falcipain-2'.

Singh N, Sijwali PS, Pandey KC, Rosenthal PJ.

Exp Parasitol. 2006 Mar;112(3):187-92. Epub 2005 Dec 7.

PMID:
16337629
19.

Falcipain inhibitors: optimization studies of the 2-pyrimidinecarbonitrile lead series.

Coterón JM, Catterick D, Castro J, Chaparro MJ, Díaz B, Fernández E, Ferrer S, Gamo FJ, Gordo M, Gut J, de las Heras L, Legac J, Marco M, Miguel J, Muñoz V, Porras E, de la Rosa JC, Ruiz JR, Sandoval E, Ventosa P, Rosenthal PJ, Fiandor JM.

J Med Chem. 2010 Aug 26;53(16):6129-52. doi: 10.1021/jm100556b. Erratum in: J Med Chem. 2010 Nov 11;53(21):7885-6.

PMID:
20672841
20.

Structure-based design, synthesis and evaluation of conformationally constrained cysteine protease inhibitors.

Scheidt KA, Roush WR, McKerrow JH, Selzer PM, Hansell E, Rosenthal PJ.

Bioorg Med Chem. 1998 Dec;6(12):2477-94.

PMID:
9925304

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