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Items: 1 to 20 of 95

1.

Genomic and protein structural maps of adaptive evolution of human influenza A virus to increased virulence in the mouse.

Ping J, Keleta L, Forbes NE, Dankar S, Stecho W, Tyler S, Zhou Y, Babiuk L, Weingartl H, Halpin RA, Boyne A, Bera J, Hostetler J, Fedorova NB, Proudfoot K, Katzel DA, Stockwell TB, Ghedin E, Spiro DJ, Brown EG.

PLoS One. 2011;6(6):e21740. doi: 10.1371/journal.pone.0021740. Epub 2011 Jun 30.

2.

PB2 and hemagglutinin mutations are major determinants of host range and virulence in mouse-adapted influenza A virus.

Ping J, Dankar SK, Forbes NE, Keleta L, Zhou Y, Tyler S, Brown EG.

J Virol. 2010 Oct;84(20):10606-18. doi: 10.1128/JVI.01187-10. Epub 2010 Aug 11.

3.

Multifunctional adaptive NS1 mutations are selected upon human influenza virus evolution in the mouse.

Forbes NE, Ping J, Dankar SK, Jia JJ, Selman M, Keleta L, Zhou Y, Brown EG.

PLoS One. 2012;7(2):e31839. doi: 10.1371/journal.pone.0031839. Epub 2012 Feb 21.

4.

A combination of HA and PA mutations enhances virulence in a mouse-adapted H6N6 influenza A virus.

Tan L, Su S, Smith DK, He S, Zheng Y, Shao Z, Ma J, Zhu H, Zhang G.

J Virol. 2014 Dec;88(24):14116-25. doi: 10.1128/JVI.01736-14. Epub 2014 Oct 1.

5.
6.

Identification of adaptive mutations in the influenza A virus non-structural 1 gene that increase cytoplasmic localization and differentially regulate host gene expression.

Forbes N, Selman M, Pelchat M, Jia JJ, Stintzi A, Brown EG.

PLoS One. 2013 Dec 31;8(12):e84673. doi: 10.1371/journal.pone.0084673. eCollection 2013.

7.

Adaptive mutations in PB2 gene contribute to the high virulence of a natural reassortant H5N2 avian influenza virus in mice.

Li Q, Wang X, Sun Z, Hu J, Gao Z, Hao X, Li J, Liu H, Wang X, Gu M, Xu X, Liu X, Liu X.

Virus Res. 2015 Dec 2;210:255-63. doi: 10.1016/j.virusres.2015.08.017. Epub 2015 Aug 24.

PMID:
26315686
8.

Experimental evolution of human influenza virus H3 hemagglutinin in the mouse lung identifies adaptive regions in HA1 and HA2.

Keleta L, Ibricevic A, Bovin NV, Brody SL, Brown EG.

J Virol. 2008 Dec;82(23):11599-608. doi: 10.1128/JVI.01393-08. Epub 2008 Oct 1. Erratum in: J Virol. 2009 Apr;83(7):3417.

9.

Virulence and genetic compatibility of polymerase reassortant viruses derived from the pandemic (H1N1) 2009 influenza virus and circulating influenza A viruses.

Song MS, Pascua PN, Lee JH, Baek YH, Park KJ, Kwon HI, Park SJ, Kim CJ, Kim H, Webby RJ, Webster RG, Choi YK.

J Virol. 2011 Jul;85(13):6275-86. doi: 10.1128/JVI.02125-10. Epub 2011 Apr 20.

10.

Influenza A virus NS1 gene mutations F103L and M106I increase replication and virulence.

Dankar SK, Wang S, Ping J, Forbes NE, Keleta L, Li Y, Brown EG.

Virol J. 2011 Jan 12;8:13. doi: 10.1186/1743-422X-8-13.

11.

Reassortment complements spontaneous mutation in influenza A virus NP and M1 genes to accelerate adaptation to a new host.

Ince WL, Gueye-Mbaye A, Bennink JR, Yewdell JW.

J Virol. 2013 Apr;87(8):4330-8. doi: 10.1128/JVI.02749-12. Epub 2013 Jan 30.

12.

Adaptive mutations resulting in enhanced polymerase activity contribute to high virulence of influenza A virus in mice.

Rolling T, Koerner I, Zimmermann P, Holz K, Haller O, Staeheli P, Kochs G.

J Virol. 2009 Jul;83(13):6673-80. doi: 10.1128/JVI.00212-09. Epub 2009 Apr 29.

13.

PB2-E627K and PA-T97I substitutions enhance polymerase activity and confer a virulent phenotype to an H6N1 avian influenza virus in mice.

Cheng K, Yu Z, Chai H, Sun W, Xin Y, Zhang Q, Huang J, Zhang K, Li X, Yang S, Wang T, Zheng X, Wang H, Qin C, Qian J, Chen H, Hua Y, Gao Y, Xia X.

Virology. 2014 Nov;468-470:207-13. doi: 10.1016/j.virol.2014.08.010. Epub 2014 Sep 6.

14.

Mouse-adapted H9N2 influenza A virus PB2 protein M147L and E627K mutations are critical for high virulence.

Wang J, Sun Y, Xu Q, Tan Y, Pu J, Yang H, Brown EG, Liu J.

PLoS One. 2012;7(7):e40752. doi: 10.1371/journal.pone.0040752. Epub 2012 Jul 10.

15.

Quantitative proteomic analysis of the influenza A virus nonstructural proteins NS1 and NS2 during natural cell infection identifies PACT as an NS1 target protein and antiviral host factor.

Tawaratsumida K, Phan V, Hrincius ER, High AA, Webby R, Redecke V, H├Ącker H.

J Virol. 2014 Aug;88(16):9038-48. doi: 10.1128/JVI.00830-14. Epub 2014 Jun 4.

16.

Mutations in polymerase genes enhanced the virulence of 2009 pandemic H1N1 influenza virus in mice.

Zhu W, Zhu Y, Qin K, Yu Z, Gao R, Yu H, Zhou J, Shu Y.

PLoS One. 2012;7(3):e33383. doi: 10.1371/journal.pone.0033383. Epub 2012 Mar 15.

17.

Interactions between the influenza A virus RNA polymerase components and retinoic acid-inducible gene I.

Li W, Chen H, Sutton T, Obadan A, Perez DR.

J Virol. 2014 Sep;88(18):10432-47. doi: 10.1128/JVI.01383-14. Epub 2014 Jun 18.

18.

Biophysical characterization of sites of host adaptive mutation in the influenza A virus RNA polymerase PB2 RNA-binding domain.

Lim K, Kim M, Lee MK, Ko J, Hong S, Choi BS.

Int J Biochem Cell Biol. 2014 Aug;53:237-45. doi: 10.1016/j.biocel.2014.05.022. Epub 2014 May 27.

PMID:
24875650
19.

Adaptation of influenza A(H1N1)pdm09 virus in experimental mouse models.

Prokopyeva EA, Sobolev IA, Prokopyev MV, Shestopalov AM.

Infect Genet Evol. 2016 Apr;39:265-71. doi: 10.1016/j.meegid.2016.01.022. Epub 2016 Jan 30.

PMID:
26829383
20.

The polymerase acidic protein gene of influenza a virus contributes to pathogenicity in a mouse model.

Song MS, Pascua PN, Lee JH, Baek YH, Lee OJ, Kim CJ, Kim H, Webby RJ, Webster RG, Choi YK.

J Virol. 2009 Dec;83(23):12325-35. doi: 10.1128/JVI.01373-09. Epub 2009 Sep 30.

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