Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 60

1.

Activation of PKR causes amyloid ß-peptide accumulation via de-repression of BACE1 expression.

Ill-Raga G, Palomer E, Wozniak MA, Ramos-Fernández E, Bosch-Morató M, Tajes M, Guix FX, Galán JJ, Clarimón J, Antúnez C, Real LM, Boada M, Itzhaki RF, Fandos C, Muñoz FJ.

PLoS One. 2011;6(6):e21456. doi: 10.1371/journal.pone.0021456. Epub 2011 Jun 28.

2.

Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2α pathway.

Mouton-Liger F, Paquet C, Dumurgier J, Bouras C, Pradier L, Gray F, Hugon J.

Biochim Biophys Acta. 2012 Jun;1822(6):885-96. doi: 10.1016/j.bbadis.2012.01.009. Epub 2012 Jan 28.

3.

Gastrodin suppresses BACE1 expression under oxidative stress condition via inhibition of the PKR/eIF2α pathway in Alzheimer's disease.

Zhang JS, Zhou SF, Wang Q, Guo JN, Liang HM, Deng JB, He WY.

Neuroscience. 2016 Jun 14;325:1-9. doi: 10.1016/j.neuroscience.2016.03.024. Epub 2016 Mar 14.

PMID:
26987953
4.

Herpes simplex virus infection causes cellular beta-amyloid accumulation and secretase upregulation.

Wozniak MA, Itzhaki RF, Shipley SJ, Dobson CB.

Neurosci Lett. 2007 Dec 18;429(2-3):95-100. Epub 2007 Oct 13.

PMID:
17980964
5.

Interaction of double-stranded RNA-dependent protein kinase (PKR) with the death receptor signaling pathway in amyloid beta (Abeta)-treated cells and in APPSLPS1 knock-in mice.

Couturier J, Morel M, Pontcharraud R, Gontier V, Fauconneau B, Paccalin M, Page G.

J Biol Chem. 2010 Jan 8;285(2):1272-82. doi: 10.1074/jbc.M109.041954. Epub 2009 Nov 4.

6.

The PKR activator PACT is induced by Aβ: involvement in Alzheimer's disease.

Paquet C, Mouton-Liger F, Meurs EF, Mazot P, Bouras C, Pradier L, Gray F, Hugon J.

Brain Pathol. 2012 Mar;22(2):219-29. doi: 10.1111/j.1750-3639.2011.00520.x. Epub 2011 Sep 16.

PMID:
21790829
7.
8.

Aβ-induced Ca(2+) influx regulates astrocytic BACE1 expression via calcineurin/NFAT4 signals.

Jin SM, Cho HJ, Kim YW, Hwang JY, Mook-Jung I.

Biochem Biophys Res Commun. 2012 Aug 31;425(3):649-55. doi: 10.1016/j.bbrc.2012.07.123. Epub 2012 Jul 27.

PMID:
22846573
9.

Activated double-stranded RNA-dependent protein kinase and neuronal death in models of Alzheimer's disease.

Page G, Rioux Bilan A, Ingrand S, Lafay-Chebassier C, Pain S, Perault Pochat MC, Bouras C, Bayer T, Hugon J.

Neuroscience. 2006;139(4):1343-54. Epub 2006 Apr 3.

PMID:
16581193
10.

Neuroinflammation and Aβ accumulation linked to systemic inflammation are decreased by genetic PKR down-regulation.

Carret-Rebillat AS, Pace C, Gourmaud S, Ravasi L, Montagne-Stora S, Longueville S, Tible M, Sudol E, Chang RC, Paquet C, Mouton-Liger F, Hugon J.

Sci Rep. 2015 Feb 17;5:8489. doi: 10.1038/srep08489.

11.

Differential regulation of BACE1 promoter activity by nuclear factor-kappaB in neurons and glia upon exposure to beta-amyloid peptides.

Bourne KZ, Ferrari DC, Lange-Dohna C, Rossner S, Wood TG, Perez-Polo JR.

J Neurosci Res. 2007 May 1;85(6):1194-204.

PMID:
17385716
12.

Sendai virus C protein plays a role in restricting PKR activation by limiting the generation of intracellular double-stranded RNA.

Takeuchi K, Komatsu T, Kitagawa Y, Sada K, Gotoh B.

J Virol. 2008 Oct;82(20):10102-10. doi: 10.1128/JVI.00599-08. Epub 2008 Aug 6.

13.

Disrupted intracellular calcium regulates BACE1 gene expression via nuclear factor of activated T cells 1 (NFAT 1) signaling.

Cho HJ, Jin SM, Youn HD, Huh K, Mook-Jung I.

Aging Cell. 2008 Mar;7(2):137-47. Epub 2007 Dec 5.

14.
16.

Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer disease.

Liang B, Duan BY, Zhou XP, Gong JX, Luo ZG.

J Biol Chem. 2010 Sep 3;285(36):27737-44. doi: 10.1074/jbc.M110.117960. Epub 2010 Jul 1.

17.

Amyloid-β₄₂ activates the expression of BACE1 through the JNK pathway.

Guglielmotto M, Monteleone D, Giliberto L, Fornaro M, Borghi R, Tamagno E, Tabaton M.

J Alzheimers Dis. 2011;27(4):871-83. doi: 10.3233/JAD-2011-110884.

PMID:
21897006
18.

Mutant ubiquitin-mediated beta-secretase stability via activation of caspase-3 is related to beta-amyloid accumulation in ischemic striatum in rats.

Zhang Y, Xiong M, Yan RQ, Sun FY.

J Cereb Blood Flow Metab. 2010 Mar;30(3):566-75. doi: 10.1038/jcbfm.2009.228. Epub 2009 Oct 21.

19.

Pharmacological inhibition of PKR in APPswePS1dE9 mice transiently prevents inflammation at 12 months of age but increases Aβ42 levels in the late stages of the Alzheimer's disease.

Couturier J, Paccalin M, Lafay-Chebassier C, Chalon S, Ingrand I, Pinguet J, Pontcharraud R, Guillard O, Fauconneau B, Page G.

Curr Alzheimer Res. 2012 Mar;9(3):344-60.

PMID:
22272616
20.

Supplemental Content

Support Center