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Items: 1 to 20 of 120

1.

Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells.

Wang H, Zou J, Zhao B, Johannsen E, Ashworth T, Wong H, Pear WS, Schug J, Blacklow SC, Arnett KL, Bernstein BE, Kieff E, Aster JC.

Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14908-13. doi: 10.1073/pnas.1109023108. Epub 2011 Jul 7.

2.

Transcription factor RBPJ/CSL: a genome-wide look at transcriptional regulation.

Miele L.

Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14715-6. doi: 10.1073/pnas.1110570108. Epub 2011 Aug 24. No abstract available. Erratum in: Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16481.

3.

Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth.

Zhao B, Zou J, Wang H, Johannsen E, Peng CW, Quackenbush J, Mar JC, Morton CC, Freedman ML, Blacklow SC, Aster JC, Bernstein BE, Kieff E.

Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14902-7. doi: 10.1073/pnas.1108892108. Epub 2011 Jul 11.

4.

NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers.

Wang H, Zang C, Taing L, Arnett KL, Wong YJ, Pear WS, Blacklow SC, Liu XS, Aster JC.

Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):705-10. doi: 10.1073/pnas.1315023111. Epub 2013 Dec 27.

5.

Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia.

Yashiro-Ohtani Y, Wang H, Zang C, Arnett KL, Bailis W, Ho Y, Knoechel B, Lanauze C, Louis L, Forsyth KS, Chen S, Chung Y, Schug J, Blobel GA, Liebhaber SA, Bernstein BE, Blacklow SC, Liu XS, Aster JC, Pear WS.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):E4946-53. doi: 10.1073/pnas.1407079111. Epub 2014 Nov 4.

6.

Modulation of gene expression via overlapping binding sites exerted by ZNF143, Notch1 and THAP11.

Ngondo-Mbongo RP, Myslinski E, Aster JC, Carbon P.

Nucleic Acids Res. 2013 Apr;41(7):4000-14. doi: 10.1093/nar/gkt088. Epub 2013 Feb 13.

7.

RBPJ, the major transcriptional effector of Notch signaling, remains associated with chromatin throughout mitosis, suggesting a role in mitotic bookmarking.

Lake RJ, Tsai PF, Choi I, Won KJ, Fan HY.

PLoS Genet. 2014 Mar 6;10(3):e1004204. doi: 10.1371/journal.pgen.1004204. eCollection 2014 Mar 6. Erratum in: PLoS Genet. 2016 Jul;12(7):e1006209.

8.

High mobility group A1 protein acts as a new target of Notch1 signaling and regulates cell proliferation in T leukemia cells.

Xi Y, Li YS, Tang HB.

Mol Cell Biochem. 2013 Feb;374(1-2):173-80. doi: 10.1007/s11010-012-1517-2. Epub 2012 Nov 16.

PMID:
23229232
9.
10.

Dynamic binding of RBPJ is determined by Notch signaling status.

Castel D, Mourikis P, Bartels SJ, Brinkman AB, Tajbakhsh S, Stunnenberg HG.

Genes Dev. 2013 May 1;27(9):1059-71. doi: 10.1101/gad.211912.112. Erratum in: Genes Dev. 2013 Jun 1;27(11):1313.

11.

Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc.

Sharma VM, Calvo JA, Draheim KM, Cunningham LA, Hermance N, Beverly L, Krishnamoorthy V, Bhasin M, Capobianco AJ, Kelliher MA.

Mol Cell Biol. 2006 Nov;26(21):8022-31. Epub 2006 Sep 5.

12.

Epstein-Barr virus nuclear antigen leader protein localizes to promoters and enhancers with cell transcription factors and EBNA2.

Portal D, Zhou H, Zhao B, Kharchenko PV, Lowry E, Wong L, Quackenbush J, Holloway D, Jiang S, Lu Y, Kieff E.

Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18537-42. doi: 10.1073/pnas.1317608110. Epub 2013 Oct 28.

13.

Loss of the Notch effector RBPJ promotes tumorigenesis.

Kulic I, Robertson G, Chang L, Baker JH, Lockwood WW, Mok W, Fuller M, Fournier M, Wong N, Chou V, Robinson MD, Chun HJ, Gilks B, Kempkes B, Thomson TA, Hirst M, Minchinton AI, Lam WL, Jones S, Marra M, Karsan A.

J Exp Med. 2015 Jan 12;212(1):37-52. doi: 10.1084/jem.20121192. Epub 2014 Dec 15.

14.

Direct regulation of interleukin-6 expression by Notch signaling in macrophages.

Wongchana W, Palaga T.

Cell Mol Immunol. 2012 Mar;9(2):155-62. doi: 10.1038/cmi.2011.36. Epub 2011 Oct 10.

15.

LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways.

Smith S, Tripathi R, Goodings C, Cleveland S, Mathias E, Hardaway JA, Elliott N, Yi Y, Chen X, Downing J, Mullighan C, Swing DA, Tessarollo L, Li L, Love P, Jenkins NA, Copeland NG, Thompson MA, Du Y, Davé UP.

PLoS One. 2014 Jan 21;9(1):e85883. doi: 10.1371/journal.pone.0085883. eCollection 2014 Jan 21.

16.

Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia.

Vilimas T, Mascarenhas J, Palomero T, Mandal M, Buonamici S, Meng F, Thompson B, Spaulding C, Macaroun S, Alegre ML, Kee BL, Ferrando A, Miele L, Aifantis I.

Nat Med. 2007 Jan;13(1):70-7. Epub 2006 Dec 17.

PMID:
17173050
17.

Identification of novel targets of CSL-dependent Notch signaling in hematopoiesis.

Hamidi H, Gustafason D, Pellegrini M, Gasson J.

PLoS One. 2011;6(5):e20022. doi: 10.1371/journal.pone.0020022. Epub 2011 May 26.

18.

The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells.

Gerhardt DM, Pajcini KV, D'altri T, Tu L, Jain R, Xu L, Chen MJ, Rentschler S, Shestova O, Wertheim GB, Tobias JW, Kluk M, Wood AW, Aster JC, Gimotty PA, Epstein JA, Speck N, Bigas A, Pear WS.

Genes Dev. 2014 Mar 15;28(6):576-93. doi: 10.1101/gad.227496.113.

19.

Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia.

Palomero T, Sulis ML, Cortina M, Real PJ, Barnes K, Ciofani M, Caparros E, Buteau J, Brown K, Perkins SL, Bhagat G, Agarwal AM, Basso G, Castillo M, Nagase S, Cordon-Cardo C, Parsons R, Zúñiga-Pflücker JC, Dominguez M, Ferrando AA.

Nat Med. 2007 Oct;13(10):1203-10. Epub 2007 Sep 16.

20.

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