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Items: 1 to 20 of 118

1.

Understanding molecular recognition by G protein βγ subunits on the path to pharmacological targeting.

Lin Y, Smrcka AV.

Mol Pharmacol. 2011 Oct;80(4):551-7. doi: 10.1124/mol.111.073072. Epub 2011 Jul 7. Review.

2.

Interaction of Gbetagamma with RACK1 and other WD40 repeat proteins.

Chen S, Spiegelberg BD, Lin F, Dell EJ, Hamm HE.

J Mol Cell Cardiol. 2004 Aug;37(2):399-406. Review.

PMID:
15276010
3.

Rational design of a selective covalent modifier of G protein βγ subunits.

Dessal AL, Prades R, Giralt E, Smrcka AV.

Mol Pharmacol. 2011 Jan;79(1):24-33. doi: 10.1124/mol.110.068155. Epub 2010 Sep 29.

4.
5.

Structural and molecular characterization of a preferred protein interaction surface on G protein beta gamma subunits.

Davis TL, Bonacci TM, Sprang SR, Smrcka AV.

Biochemistry. 2005 Aug 9;44(31):10593-604.

PMID:
16060668
6.

G protein betagamma subunits as targets for small molecule therapeutic development.

Smrcka AV, Lehmann DM, Dessal AL.

Comb Chem High Throughput Screen. 2008 Jun;11(5):382-95. Review.

7.

The expanding roles of Gβγ subunits in G protein-coupled receptor signaling and drug action.

Khan SM, Sleno R, Gora S, Zylbergold P, Laverdure JP, Labbé JC, Miller GJ, Hébert TE.

Pharmacol Rev. 2013 Feb 13;65(2):545-77. doi: 10.1124/pr.111.005603. Print 2013 Apr. Review.

8.

Direct-reversible binding of small molecules to G protein βγ subunits.

Seneviratne AM, Burroughs M, Giralt E, Smrcka AV.

Biochim Biophys Acta. 2011 Sep;1814(9):1210-8. doi: 10.1016/j.bbapap.2011.05.010. Epub 2011 May 18.

9.

Molecular targeting of Gα and Gβγ subunits: a potential approach for cancer therapeutics.

Smrcka AV.

Trends Pharmacol Sci. 2013 May;34(5):290-8. doi: 10.1016/j.tips.2013.02.006. Epub 2013 Apr 1. Review.

10.

Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity.

Howlett AC, Gray AJ, Hunter JM, Willardson BM.

J Biol Chem. 2009 Jun 12;284(24):16386-99. doi: 10.1074/jbc.M900800200. Epub 2009 Apr 17.

11.

Specificity of Gbetagamma signaling to Kir3 channels depends on the helical domain of pertussis toxin-sensitive Galpha subunits.

Rusinova R, Mirshahi T, Logothetis DE.

J Biol Chem. 2007 Nov 23;282(47):34019-30. Epub 2007 Sep 14.

12.

Evidence for a second, high affinity Gbetagamma binding site on Galphai1(GDP) subunits.

Wang J, Sengupta P, Guo Y, Golebiewska U, Scarlata S.

J Biol Chem. 2009 Jun 19;284(25):16906-13. doi: 10.1074/jbc.M109.006585. Epub 2009 Apr 15.

13.

Critical determinants of the G protein gamma subunits in the Gbetagamma stimulation of G protein-activated inwardly rectifying potassium (GIRK) channel activity.

Peng L, Mirshahi T, Zhang H, Hirsch JP, Logothetis DE.

J Biol Chem. 2003 Dec 12;278(50):50203-11. Epub 2003 Sep 15.

14.
15.

A docking site for G protein βγ subunits on the parathyroid hormone 1 receptor supports signaling through multiple pathways.

Mahon MJ, Bonacci TM, Divieti P, Smrcka AV.

Mol Endocrinol. 2006 Jan;20(1):136-46. Epub 2005 Aug 11.

PMID:
16099817
16.

Differential targeting of Gbetagamma-subunit signaling with small molecules.

Bonacci TM, Mathews JL, Yuan C, Lehmann DM, Malik S, Wu D, Font JL, Bidlack JM, Smrcka AV.

Science. 2006 Apr 21;312(5772):443-6.

17.

The role of Gbetagamma subunits in the organization, assembly, and function of GPCR signaling complexes.

Dupré DJ, Robitaille M, Rebois RV, Hébert TE.

Annu Rev Pharmacol Toxicol. 2009;49:31-56. doi: 10.1146/annurev-pharmtox-061008-103038. Review.

18.

The role of G beta gamma and domain interfaces in the activation of G protein-coupled receptor kinase 2.

Lodowski DT, Barnhill JF, Pyskadlo RM, Ghirlando R, Sterne-Marr R, Tesmer JJ.

Biochemistry. 2005 May 10;44(18):6958-70.

PMID:
15865441
19.

Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex.

Tesmer VM, Kawano T, Shankaranarayanan A, Kozasa T, Tesmer JJ.

Science. 2005 Dec 9;310(5754):1686-90.

20.

Chaperone-mediated assembly of G protein complexes.

Willardson BM, Tracy CM.

Subcell Biochem. 2012;63:131-53. doi: 10.1007/978-94-007-4765-4_8. Review.

PMID:
23161137

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