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Items: 1 to 20 of 198

1.

Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family.

Duret G, Van Renterghem C, Weng Y, Prevost M, Moraga-Cid G, Huon C, Sonner JM, Corringer PJ.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12143-8. doi: 10.1073/pnas.1104494108. Epub 2011 Jul 5.

2.
3.

Multisite binding of a general anesthetic to the prokaryotic pentameric Erwinia chrysanthemi ligand-gated ion channel (ELIC).

Spurny R, Billen B, Howard RJ, Brams M, Debaveye S, Price KL, Weston DA, Strelkov SV, Tytgat J, Bertrand S, Bertrand D, Lummis SC, Ulens C.

J Biol Chem. 2013 Mar 22;288(12):8355-64. doi: 10.1074/jbc.M112.424507. Epub 2013 Jan 30.

4.

Structural basis for alcohol modulation of a pentameric ligand-gated ion channel.

Howard RJ, Murail S, Ondricek KE, Corringer PJ, Lindahl E, Trudell JR, Harris RA.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12149-54. doi: 10.1073/pnas.1104480108. Epub 2011 Jul 5.

5.

Ethanol Modulation is Quantitatively Determined by the Transmembrane Domain of Human α1 Glycine Receptors.

Horani S, Stater EP, Corringer PJ, Trudell JR, Harris RA, Howard RJ.

Alcohol Clin Exp Res. 2015 Jun;39(6):962-8. doi: 10.1111/acer.12735. Epub 2015 May 14.

6.

A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family.

Bocquet N, Prado de Carvalho L, Cartaud J, Neyton J, Le Poupon C, Taly A, Grutter T, Changeux JP, Corringer PJ.

Nature. 2007 Jan 4;445(7123):116-9. Epub 2006 Dec 10.

PMID:
17167423
7.

Intermediate closed state for glycine receptor function revealed by cysteine cross-linking.

Prevost MS, Moraga-Cid G, Van Renterghem C, Edelstein SJ, Changeux JP, Corringer PJ.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17113-8. doi: 10.1073/pnas.1317009110. Epub 2013 Oct 1.

8.

Allosteric and hyperekplexic mutant phenotypes investigated on an α1 glycine receptor transmembrane structure.

Moraga-Cid G, Sauguet L, Huon C, Malherbe L, Girard-Blanc C, Petres S, Murail S, Taly A, Baaden M, Delarue M, Corringer PJ.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2865-70. doi: 10.1073/pnas.1417864112. Epub 2015 Feb 17.

9.

Identification of cinnamic acid derivatives as novel antagonists of the prokaryotic proton-gated ion channel GLIC.

Prevost MS, Delarue-Cochin S, Marteaux J, Colas C, Van Renterghem C, Blondel A, Malliavin T, Corringer PJ, Joseph D.

J Med Chem. 2013 Jun 13;56(11):4619-30. doi: 10.1021/jm400374q. Epub 2013 Jun 4.

PMID:
23682762
10.

Site-directed spin labeling reveals pentameric ligand-gated ion channel gating motions.

Dellisanti CD, Ghosh B, Hanson SM, Raspanti JM, Grant VA, Diarra GM, Schuh AM, Satyshur K, Klug CS, Czajkowski C.

PLoS Biol. 2013 Nov;11(11):e1001714. doi: 10.1371/journal.pbio.1001714. Epub 2013 Nov 19.

11.

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation.

Sauguet L, Shahsavar A, Poitevin F, Huon C, Menny A, Nemecz À, Haouz A, Changeux JP, Corringer PJ, Delarue M.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):966-71. doi: 10.1073/pnas.1314997111. Epub 2013 Dec 23.

12.

3D structure and allosteric modulation of the transmembrane domain of pentameric ligand-gated ion channels.

Baenziger JE, Corringer PJ.

Neuropharmacology. 2011 Jan;60(1):116-25. doi: 10.1016/j.neuropharm.2010.08.007. Epub 2010 Aug 14. Review.

PMID:
20713066
13.

Functional Chimeras of GLIC Obtained by Adding the Intracellular Domain of Anion- and Cation-Conducting Cys-Loop Receptors.

Mnatsakanyan N, Nishtala SN, Pandhare A, Fiori MC, Goyal R, Pauwels JE, Navetta AF, Ahrorov A, Jansen M.

Biochemistry. 2015 Apr 28;54(16):2670-82. doi: 10.1021/acs.biochem.5b00203. Epub 2015 Apr 17.

14.

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel.

Nury H, Van Renterghem C, Weng Y, Tran A, Baaden M, Dufresne V, Changeux JP, Sonner JM, Delarue M, Corringer PJ.

Nature. 2011 Jan 20;469(7330):428-31. doi: 10.1038/nature09647.

PMID:
21248852
15.

Reversal of ion-charge selectivity renders the pentameric ligand-gated ion channel GLIC insensitive to anaesthetics.

Tillman T, Cheng MH, Chen Q, Tang P, Xu Y.

Biochem J. 2013 Jan 1;449(1):61-8. doi: 10.1042/BJ20121072.

16.

Molecular tuning of fast gating in pentameric ligand-gated ion channels.

Grutter T, de Carvalho LP, Dufresne V, Taly A, Edelstein SJ, Changeux JP.

Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18207-12. Epub 2005 Nov 30.

17.

Structure of the pentameric ligand-gated ion channel GLIC bound with anesthetic ketamine.

Pan J, Chen Q, Willenbring D, Mowrey D, Kong XP, Cohen A, Divito CB, Xu Y, Tang P.

Structure. 2012 Sep 5;20(9):1463-9. doi: 10.1016/j.str.2012.08.009.

18.

Atomic structure and dynamics of pentameric ligand-gated ion channels: new insight from bacterial homologues.

Corringer PJ, Baaden M, Bocquet N, Delarue M, Dufresne V, Nury H, Prevost M, Van Renterghem C.

J Physiol. 2010 Feb 15;588(Pt 4):565-72. doi: 10.1113/jphysiol.2009.183160. Epub 2009 Dec 7. Review.

19.

Ion selectivity mechanism in a bacterial pentameric ligand-gated ion channel.

Fritsch S, Ivanov I, Wang H, Cheng X.

Biophys J. 2011 Jan 19;100(2):390-8. doi: 10.1016/j.bpj.2010.11.077.

20.

Inhibition versus potentiation of ligand-gated ion channels can be altered by a single mutation that moves ligands between intra- and intersubunit sites.

Brömstrup T, Howard RJ, Trudell JR, Harris RA, Lindahl E.

Structure. 2013 Aug 6;21(8):1307-16. doi: 10.1016/j.str.2013.06.018. Epub 2013 Jul 25.

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