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Items: 1 to 20 of 106

1.

Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging.

Cochran R, Kalisiak J, Küçükkilinç T, Radic Z, Garcia E, Zhang L, Ho KY, Amitai G, Kovarik Z, Fokin VV, Sharpless KB, Taylor P.

J Biol Chem. 2011 Aug 26;286(34):29718-24. doi: 10.1074/jbc.M111.264739. Epub 2011 Jul 5.

2.

Mutant cholinesterases possessing enhanced capacity for reactivation of their phosphonylated conjugates.

Kovarik Z, Radić Z, Berman HA, Simeon-Rudolf V, Reiner E, Taylor P.

Biochemistry. 2004 Mar 23;43(11):3222-9.

PMID:
15023072
3.

HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants.

Maček Hrvat N, Žunec S, Taylor P, Radić Z, Kovarik Z.

Chem Biol Interact. 2016 Nov 25;259(Pt B):148-153. doi: 10.1016/j.cbi.2016.04.023. Epub 2016 Apr 12.

4.

Catalytic Soman Scavenging by the Y337A/F338A Acetylcholinesterase Mutant Assisted with Novel Site-Directed Aldoximes.

Kovarik Z, Maček Hrvat N, Katalinić M, Sit RK, Paradyse A, Žunec S, Musilek K, Fokin VV, Taylor P, Radić Z.

Chem Res Toxicol. 2015 May 18;28(5):1036-44. doi: 10.1021/acs.chemrestox.5b00060. Epub 2015 Apr 16.

5.

Phosphoryl oxime inhibition of acetylcholinesterase during oxime reactivation is prevented by edrophonium.

Luo C, Saxena A, Smith M, Garcia G, Radić Z, Taylor P, Doctor BP.

Biochemistry. 1999 Aug 3;38(31):9937-47.

PMID:
10433700
6.

Centrally acting oximes in reactivation of tabun-phosphoramidated AChE.

Kovarik Z, Maček N, Sit RK, Radić Z, Fokin VV, Barry Sharpless K, Taylor P.

Chem Biol Interact. 2013 Mar 25;203(1):77-80. doi: 10.1016/j.cbi.2012.08.019. Epub 2012 Sep 7.

7.

In silico studies on the role of mutant Y337A to reactivate tabun inhibited mAChE with K048.

Chandar NB, Ghosh S, Lo R, Banjo S, Ganguly B.

Chem Biol Interact. 2015 Dec 5;242:299-306. doi: 10.1016/j.cbi.2015.10.016. Epub 2015 Oct 19.

PMID:
26494532
8.

The reactivation of tabun-inhibited mutant AChE with Ortho-7: steered molecular dynamics and quantum chemical studies.

Lo R, Chandar NB, Ghosh S, Ganguly B.

Mol Biosyst. 2016 Apr;12(4):1224-31. doi: 10.1039/c5mb00735f. Epub 2016 Feb 16.

PMID:
26879641
9.

Interactions between xylene-linked carbamoyl bis-pyridinium mono-oximes and organophosphates inhibited-AChE: a kinetic study.

Sharma R, Gupta B, Acharya J, Kaushik MP, Ghosh KK.

Toxicology. 2014 Feb 28;316:1-8. doi: 10.1016/j.tox.2013.11.011. Epub 2013 Dec 15.

PMID:
24345352
10.

Suitability of human butyrylcholinesterase as therapeutic marker and pseudo catalytic scavenger in organophosphate poisoning: a kinetic analysis.

Aurbek N, Thiermann H, Eyer F, Eyer P, Worek F.

Toxicology. 2009 May 17;259(3):133-9. doi: 10.1016/j.tox.2009.02.014. Epub 2009 Mar 6.

PMID:
19428953
11.

Active site mutant acetylcholinesterase interactions with 2-PAM, HI-6, and DDVP.

Kovarik Z, Ciban N, Radić Z, Simeon-Rudolf V, Taylor P.

Biochem Biophys Res Commun. 2006 Apr 14;342(3):973-8.

PMID:
16598855
12.

Mechanism of oxime reactivation of acetylcholinesterase analyzed by chirality and mutagenesis.

Wong L, Radic Z, Brüggemann RJ, Hosea N, Berman HA, Taylor P.

Biochemistry. 2000 May 16;39(19):5750-7.

PMID:
10801325
13.

In vitro reactivation of acetylcholinesterase using the oxime K027.

Kuca K, Kassa J.

Vet Hum Toxicol. 2004 Feb;46(1):15-8.

PMID:
14748409
14.

Mutant acetylcholinesterases as potential detoxification agents for organophosphate poisoning.

Saxena A, Maxwell DM, Quinn DM, Radić Z, Taylor P, Doctor BP.

Biochem Pharmacol. 1997 Jul 15;54(2):269-74.

PMID:
9271331
15.

Synthesis and in-vitro reactivation screening of imidazolium aldoximes as reactivators of sarin and VX-inhibited human acetylcholinesterase (hAChE).

Sharma R, Gupta B, Sahu AK, Acharya J, Satnami ML, Ghosh KK.

Chem Biol Interact. 2016 Nov 25;259(Pt B):85-92. doi: 10.1016/j.cbi.2016.04.034. Epub 2016 Apr 29.

PMID:
27138243
16.

Synthesis and in vitro kinetic evaluation of N-thiazolylacetamido monoquaternary pyridinium oximes as reactivators of sarin, O-ethylsarin and VX inhibited human acetylcholinesterase (hAChE).

Valiveti AK, Bhalerao UM, Acharya J, Karade HN, Acharya BN, Raviraju G, Halve AK, Kaushik MP.

Bioorg Med Chem. 2015 Aug 1;23(15):4899-910. doi: 10.1016/j.bmc.2015.05.027. Epub 2015 May 22.

PMID:
26043948
17.

A common mechanism for resistance to oxime reactivation of acetylcholinesterase inhibited by organophosphorus compounds.

Maxwell DM, Brecht KM, Sweeney RE.

Chem Biol Interact. 2013 Mar 25;203(1):72-6. doi: 10.1016/j.cbi.2012.08.024. Epub 2012 Sep 12.

PMID:
22982773
18.

Enzyme-kinetic investigation of different sarin analogues reacting with human acetylcholinesterase and butyrylcholinesterase.

Bartling A, Worek F, Szinicz L, Thiermann H.

Toxicology. 2007 Apr 20;233(1-3):166-72. Epub 2006 Jul 7.

PMID:
16904809
19.

Pseudo-catalytic scavenging: searching for a suitable reactivator of phosphorylated butyrylcholinesterase.

Kovarik Z, Katalinić M, Sinko G, Binder J, Holas O, Jung YS, Musilova L, Jun D, Kuca K.

Chem Biol Interact. 2010 Sep 6;187(1-3):167-71. doi: 10.1016/j.cbi.2010.02.023. Epub 2010 Mar 3.

PMID:
20206154
20.

Investigating the structural influence of surface mutations on acetylcholinesterase inhibition by organophosphorus compounds and oxime reactivation.

Küçükkilinç T, Cochran R, Kalisiak J, Garcia E, Valle A, Amitai G, Radić Z, Taylor P.

Chem Biol Interact. 2010 Sep 6;187(1-3):238-40. doi: 10.1016/j.cbi.2010.03.050. Epub 2010 Apr 9.

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