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Items: 1 to 20 of 99

1.

SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver.

Takahashi A, Tsutsumi R, Kikuchi I, Obuse C, Saito Y, Seidi A, Karisch R, Fernandez M, Cho T, Ohnishi N, Rozenblatt-Rosen O, Meyerson M, Neel BG, Hatakeyama M.

Mol Cell. 2011 Jul 8;43(1):45-56. doi: 10.1016/j.molcel.2011.05.014.

2.

Determination of the catalytic activity of LEOPARD syndrome-associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling.

Noda S, Takahashi A, Hayashi T, Tanuma S, Hatakeyama M.

Biochem Biophys Res Commun. 2016 Jan 22;469(4):1133-9. doi: 10.1016/j.bbrc.2015.12.117. Epub 2015 Dec 29.

PMID:
26742426
3.

YAP and TAZ, Hippo signaling targets, act as a rheostat for nuclear SHP2 function.

Tsutsumi R, Masoudi M, Takahashi A, Fujii Y, Hayashi T, Kikuchi I, Satou Y, Taira M, Hatakeyama M.

Dev Cell. 2013 Sep 30;26(6):658-65. doi: 10.1016/j.devcel.2013.08.013. Epub 2013 Sep 12.

4.

The tumor suppressor, parafibromin, mediates histone H3 K9 methylation for cyclin D1 repression.

Yang YJ, Han JW, Youn HD, Cho EJ.

Nucleic Acids Res. 2010 Jan;38(2):382-90. doi: 10.1093/nar/gkp991. Epub 2009 Nov 11.

5.
6.

NGX6 inhibits cell invasion and adhesion through suppression of Wnt/beta-catenin signal pathway in colon cancer.

Guo Q, Shen S, Liao M, Lian P, Wang X.

Acta Biochim Biophys Sin (Shanghai). 2010 Jul;42(7):450-6. doi: 10.1093/abbs/gmq049. Epub 2010 Jun 13.

7.

Parafibromin, product of the hyperparathyroidism-jaw tumor syndrome gene HRPT2, regulates cyclin D1/PRAD1 expression.

Woodard GE, Lin L, Zhang JH, Agarwal SK, Marx SJ, Simonds WF.

Oncogene. 2005 Feb 10;24(7):1272-6.

PMID:
15580289
8.

Protein kinase C delta negatively modulates canonical Wnt pathway and cell proliferation in colon tumor cell lines.

Hernández-Maqueda JG, Luna-Ulloa LB, Santoyo-Ramos P, Castañeda-Patlán MC, Robles-Flores M.

PLoS One. 2013;8(3):e58540. doi: 10.1371/journal.pone.0058540. Epub 2013 Mar 8.

9.

Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways.

Kikuchi I, Takahashi-Kanemitsu A, Sakiyama N, Tang C, Tang PJ, Noda S, Nakao K, Kassai H, Sato T, Aiba A, Hatakeyama M.

Nat Commun. 2016 Sep 21;7:12887. doi: 10.1038/ncomms12887.

10.

Epigenetic inactivation of Wnt inhibitory factor-1 plays an important role in bladder cancer through aberrant canonical Wnt/beta-catenin signaling pathway.

Urakami S, Shiina H, Enokida H, Kawakami T, Tokizane T, Ogishima T, Tanaka Y, Li LC, Ribeiro-Filho LA, Terashima M, Kikuno N, Adachi H, Yoneda T, Kishi H, Shigeno K, Konety BR, Igawa M, Dahiya R.

Clin Cancer Res. 2006 Jan 15;12(2):383-91.

11.

Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis.

Bard-Chapeau EA, Li S, Ding J, Zhang SS, Zhu HH, Princen F, Fang DD, Han T, Bailly-Maitre B, Poli V, Varki NM, Wang H, Feng GS.

Cancer Cell. 2011 May 17;19(5):629-39. doi: 10.1016/j.ccr.2011.03.023.

12.

Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin.

Wang HL, Wang J, Xiao SY, Haydon R, Stoiber D, He TC, Bissonnette M, Hart J.

Int J Cancer. 2002 Oct 1;101(4):301-10.

13.
14.

The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of β-catenin phosphorylation.

Timmerman I, Hoogenboezem M, Bennett AM, Geerts D, Hordijk PL, van Buul JD.

Mol Biol Cell. 2012 Nov;23(21):4212-25. doi: 10.1091/mbc.E12-01-0038. Epub 2012 Sep 5.

15.

A signaling loop of REST, TSC2 and β-catenin governs proliferation and function of PC12 neural cells.

Tomasoni R, Negrini S, Fiordaliso S, Klajn A, Tkatch T, Mondino A, Meldolesi J, D'Alessandro R.

J Cell Sci. 2011 Sep 15;124(Pt 18):3174-86. doi: 10.1242/jcs.087551. Epub 2011 Aug 24.

16.

The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.

Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG.

J Biol Chem. 2008 Nov 28;283(48):33053-8. doi: 10.1074/jbc.M804039200. Epub 2008 Oct 6.

17.

Loss of parafibromin expression in a subset of parathyroid adenomas.

Juhlin C, Larsson C, Yakoleva T, Leibiger I, Leibiger B, Alimov A, Weber G, Höög A, Villablanca A.

Endocr Relat Cancer. 2006 Jun;13(2):509-23.

18.

[Establishment of hepatic stem cell line stably expressing HBx protein and the effect of HBx on cell proliferation].

Lu Y, Shen L, Li H, Hu D, Zhang X, Hu B, Feng T, Huang J.

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013 Mar;29(3):256-60. Chinese.

PMID:
23643081
19.

SOX1 functions as a tumor suppressor by antagonizing the WNT/β-catenin signaling pathway in hepatocellular carcinoma.

Tsao CM, Yan MD, Shih YL, Yu PN, Kuo CC, Lin WC, Li HJ, Lin YW.

Hepatology. 2012 Dec;56(6):2277-87. doi: 10.1002/hep.25933.

PMID:
22767186
20.

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