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Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling.

Yadav H, Quijano C, Kamaraju AK, Gavrilova O, Malek R, Chen W, Zerfas P, Zhigang D, Wright EC, Stuelten C, Sun P, Lonning S, Skarulis M, Sumner AE, Finkel T, Rane SG.

Cell Metab. 2011 Jul 6;14(1):67-79. doi: 10.1016/j.cmet.2011.04.013.


The roles of transforming growth factor-β and Smad3 signaling in adipocyte differentiation and obesity.

Tsurutani Y, Fujimoto M, Takemoto M, Irisuna H, Koshizaka M, Onishi S, Ishikawa T, Mezawa M, He P, Honjo S, Maezawa Y, Saito Y, Yokote K.

Biochem Biophys Res Commun. 2011 Apr 1;407(1):68-73. doi: 10.1016/j.bbrc.2011.02.106.


BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis.

Qian SW, Tang Y, Li X, Liu Y, Zhang YY, Huang HY, Xue RD, Yu HY, Guo L, Gao HD, Liu Y, Sun X, Li YM, Jia WP, Tang QQ.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):E798-807. doi: 10.1073/pnas.1215236110.


Smad3 deficiency in mice protects against insulin resistance and obesity induced by a high-fat diet.

Tan CK, Leuenberger N, Tan MJ, Yan YW, Chen Y, Kambadur R, Wahli W, Tan NS.

Diabetes. 2011 Feb;60(2):464-76. doi: 10.2337/db10-0801.


Transforming growth factor-beta/Smad3 signaling regulates insulin gene transcription and pancreatic islet beta-cell function.

Lin HM, Lee JH, Yadav H, Kamaraju AK, Liu E, Zhigang D, Vieira A, Kim SJ, Collins H, Matschinsky F, Harlan DM, Roberts AB, Rane SG.

J Biol Chem. 2009 May 1;284(18):12246-57. doi: 10.1074/jbc.M805379200.


From white to brown fat through the PGC-1α-dependent myokine irisin: implications for diabetes and obesity.

Castillo-Quan JI.

Dis Model Mech. 2012 May;5(3):293-5. doi: 10.1242/dmm.009894. No abstract available.


Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity.

Bi P, Shan T, Liu W, Yue F, Yang X, Liang XR, Wang J, Li J, Carlesso N, Liu X, Kuang S.

Nat Med. 2014 Aug;20(8):911-8. doi: 10.1038/nm.3615.


Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis.

Ma X, Xu L, Alberobello AT, Gavrilova O, Bagattin A, Skarulis M, Liu J, Finkel T, Mueller E.

Cell Metab. 2015 Oct 6;22(4):695-708. doi: 10.1016/j.cmet.2015.08.005.


Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts.

Piek E, Ju WJ, Heyer J, Escalante-Alcalde D, Stewart CL, Weinstein M, Deng C, Kucherlapati R, Bottinger EP, Roberts AB.

J Biol Chem. 2001 Jun 8;276(23):19945-53.


Rosiglitazone-induced mitochondrial biogenesis in white adipose tissue is independent of peroxisome proliferator-activated receptor γ coactivator-1α.

Pardo R, Enguix N, Lasheras J, Feliu JE, Kralli A, Villena JA.

PLoS One. 2011;6(11):e26989. doi: 10.1371/journal.pone.0026989.


NT-PGC-1α activation attenuates high-fat diet-induced obesity by enhancing brown fat thermogenesis and adipose tissue oxidative metabolism.

Jun HJ, Joshi Y, Patil Y, Noland RC, Chang JS.

Diabetes. 2014 Nov;63(11):3615-25. doi: 10.2337/db13-1837.


Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism.

Pan D, Fujimoto M, Lopes A, Wang YX.

Cell. 2009 Apr 3;137(1):73-86. doi: 10.1016/j.cell.2009.01.051.

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