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Items: 1 to 20 of 113


Rab35 GTPase and OCRL phosphatase remodel lipids and F-actin for successful cytokinesis.

Dambournet D, Machicoane M, Chesneau L, Sachse M, Rocancourt M, El Marjou A, Formstecher E, Salomon R, Goud B, Echard A.

Nat Cell Biol. 2011 Jun 26;13(8):981-8. doi: 10.1038/ncb2279.


Rab35 GTPase Triggers Switch-like Recruitment of the Lowe Syndrome Lipid Phosphatase OCRL on Newborn Endosomes.

Cauvin C, Rosendale M, Gupta-Rossi N, Rocancourt M, Larraufie P, Salomon R, Perrais D, Echard A.

Curr Biol. 2016 Jan 11;26(1):120-8. doi: 10.1016/j.cub.2015.11.040. Epub 2015 Dec 24.


Rab35 regulates an endocytic recycling pathway essential for the terminal steps of cytokinesis.

Kouranti I, Sachse M, Arouche N, Goud B, Echard A.

Curr Biol. 2006 Sep 5;16(17):1719-25.


Actin regulation during abscission: unexpected roles of Rab35 and endocytic transport.

Prekeris R.

Cell Res. 2011 Sep;21(9):1283-5. doi: 10.1038/cr.2011.131. Epub 2011 Aug 16. No abstract available.


Phosphatidylinositol 5-phosphatase oculocerebrorenal syndrome of Lowe protein (OCRL) controls actin dynamics during early steps of Listeria monocytogenes infection.

Kühbacher A, Dambournet D, Echard A, Cossart P, Pizarro-Cerdá J.

J Biol Chem. 2012 Apr 13;287(16):13128-36. doi: 10.1074/jbc.M111.315788. Epub 2012 Feb 18.


An ARF6/Rab35 GTPase cascade for endocytic recycling and successful cytokinesis.

Chesneau L, Dambournet D, Machicoane M, Kouranti I, Fukuda M, Goud B, Echard A.

Curr Biol. 2012 Jan 24;22(2):147-53. doi: 10.1016/j.cub.2011.11.058. Epub 2012 Jan 5.


OCRL controls trafficking through early endosomes via PtdIns4,5P₂-dependent regulation of endosomal actin.

Vicinanza M, Di Campli A, Polishchuk E, Santoro M, Di Tullio G, Godi A, Levtchenko E, De Leo MG, Polishchuk R, Sandoval L, Marzolo MP, De Matteis MA.

EMBO J. 2011 Oct 4;30(24):4970-85. doi: 10.1038/emboj.2011.354.


OCRL-mutated fibroblasts from patients with Dent-2 disease exhibit INPP5B-independent phenotypic variability relatively to Lowe syndrome cells.

Montjean R, Aoidi R, Desbois P, Rucci J, Trichet M, Salomon R, Rendu J, Fauré J, Lunardi J, Gacon G, Billuart P, Dorseuil O.

Hum Mol Genet. 2015 Feb 15;24(4):994-1006. doi: 10.1093/hmg/ddu514. Epub 2014 Oct 9.


Membrane traffic and polarization of lipid domains during cytokinesis.

Echard A.

Biochem Soc Trans. 2008 Jun;36(Pt 3):395-9. doi: 10.1042/BST0360395. Review.


Lowe syndrome, a deficiency of phosphatidylinositol 4,5-bisphosphate 5-phosphatase in the Golgi apparatus.

Suchy SF, Olivos-Glander IM, Nussabaum RL.

Hum Mol Genet. 1995 Dec;4(12):2245-50.


A role of OCRL in clathrin-coated pit dynamics and uncoating revealed by studies of Lowe syndrome cells.

Nández R, Balkin DM, Messa M, Liang L, Paradise S, Czapla H, Hein MY, Duncan JS, Mann M, De Camilli P.

Elife. 2014 Aug 8;3:e02975. doi: 10.7554/eLife.02975.


Phosphoinositides and cytokinesis: the "PIP" of the iceberg.

Echard A.

Cytoskeleton (Hoboken). 2012 Nov;69(11):893-912. doi: 10.1002/cm.21067. Epub 2012 Sep 25. Review.


The 5-phosphatase OCRL mediates retrograde transport of the mannose 6-phosphate receptor by regulating a Rac1-cofilin signalling module.

van Rahden VA, Brand K, Najm J, Heeren J, Pfeffer SR, Braulke T, Kutsche K.

Hum Mol Genet. 2012 Dec 1;21(23):5019-38. doi: 10.1093/hmg/dds343. Epub 2012 Aug 19.


Annexin A2 at the interface between F-actin and membranes enriched in phosphatidylinositol 4,5,-bisphosphate.

Hayes MJ, Shao DM, Grieve A, Levine T, Bailly M, Moss SE.

Biochim Biophys Acta. 2009 Jun;1793(6):1086-95. doi: 10.1016/j.bbamcr.2008.10.007. Epub 2008 Oct 29.


The inositol 5-phosphatase dOCRL controls PI(4,5)P2 homeostasis and is necessary for cytokinesis.

Ben El Kadhi K, Roubinet C, Solinet S, Emery G, Carréno S.

Curr Biol. 2011 Jun 21;21(12):1074-9. doi: 10.1016/j.cub.2011.05.030. Epub 2011 Jun 9.


Structure and function of the Lowe syndrome protein OCRL1.

Lowe M.

Traffic. 2005 Sep;6(9):711-9. Review.


The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane.

Ivetac I, Munday AD, Kisseleva MV, Zhang XM, Luff S, Tiganis T, Whisstock JC, Rowe T, Majerus PW, Mitchell CA.

Mol Biol Cell. 2005 May;16(5):2218-33. Epub 2005 Feb 16.


A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1.

Hou X, Hagemann N, Schoebel S, Blankenfeldt W, Goody RS, Erdmann KS, Itzen A.

EMBO J. 2011 Apr 20;30(8):1659-70. doi: 10.1038/emboj.2011.60. Epub 2011 Mar 4.


The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase.

Zhang X, Jefferson AB, Auethavekiat V, Majerus PW.

Proc Natl Acad Sci U S A. 1995 May 23;92(11):4853-6.

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