Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 167


In vitro system capable of differentiating fast Ca2+-triggered content mixing from lipid exchange for mechanistic studies of neurotransmitter release.

Kyoung M, Srivastava A, Zhang Y, Diao J, Vrljic M, Grob P, Nogales E, Chu S, Brunger AT.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):E304-13. doi: 10.1073/pnas.1107900108. Epub 2011 Jun 24.


Complexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanisms.

Lai Y, Diao J, Cipriano DJ, Zhang Y, Pfuetzner RA, Padolina MS, Brunger AT.

Elife. 2014 Aug 13;3:e03756. doi: 10.7554/eLife.03756.


A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis.

Tang J, Maximov A, Shin OH, Dai H, Rizo J, Südhof TC.

Cell. 2006 Sep 22;126(6):1175-87.


Studying calcium-triggered vesicle fusion in a single vesicle-vesicle content and lipid-mixing system.

Kyoung M, Zhang Y, Diao J, Chu S, Brunger AT.

Nat Protoc. 2013 Jan;8(1):1-16. doi: 10.1038/nprot.2012.134. Epub 2012 Dec 6.


Munc18a does not alter fusion rates mediated by neuronal SNAREs, synaptotagmin, and complexin.

Zhang Y, Diao J, Colbert KN, Lai Y, Pfuetzner RA, Padolina MS, Vivona S, Ressl S, Cipriano DJ, Choi UB, Shah N, Weis WI, Brunger AT.

J Biol Chem. 2015 Apr 17;290(16):10518-34. doi: 10.1074/jbc.M114.630772. Epub 2015 Feb 25.


The voltage-gated Ca2+ channel is the Ca2+ sensor of fast neurotransmitter release.

Atlas D, Wiser O, Trus M.

Cell Mol Neurobiol. 2001 Dec;21(6):717-31.


Direct interaction of SNARE complex binding protein synaphin/complexin with calcium sensor synaptotagmin 1.

Tokumaru H, Shimizu-Okabe C, Abe T.

Brain Cell Biol. 2008 Dec;36(5-6):173-89. doi: 10.1007/s11068-008-9032-9. Epub 2009 Jan 9.


Complexin controls spontaneous and evoked neurotransmitter release by regulating the timing and properties of synaptotagmin activity.

Jorquera RA, Huntwork-Rodriguez S, Akbergenova Y, Cho RW, Littleton JT.

J Neurosci. 2012 Dec 12;32(50):18234-45. doi: 10.1523/JNEUROSCI.3212-12.2012.


Complexin arrests a pool of docked vesicles for fast Ca2+-dependent release.

Malsam J, Parisotto D, Bharat TA, Scheutzow A, Krause JM, Briggs JA, Söllner TH.

EMBO J. 2012 Aug 1;31(15):3270-81. doi: 10.1038/emboj.2012.164. Epub 2012 Jun 15.


SNAREpin assembly by Munc18-1 requires previous vesicle docking by synaptotagmin 1.

Parisotto D, Malsam J, Scheutzow A, Krause JM, Söllner TH.

J Biol Chem. 2012 Sep 7;287(37):31041-9. doi: 10.1074/jbc.M112.386805. Epub 2012 Jul 18.


Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion.

Diao J, Grob P, Cipriano DJ, Kyoung M, Zhang Y, Shah S, Nguyen A, Padolina M, Srivastava A, Vrljic M, Shah A, Nogales E, Chu S, Brunger AT.

Elife. 2012 Dec 13;1:e00109. doi: 10.7554/eLife.00109. Erratum in: Elife. 2015;4:e12289.


Hemifusion arrest by complexin is relieved by Ca2+-synaptotagmin I.

Schaub JR, Lu X, Doneske B, Shin YK, McNew JA.

Nat Struct Mol Biol. 2006 Aug;13(8):748-50. Epub 2006 Jul 16.


Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release.

Yao J, Gaffaney JD, Kwon SE, Chapman ER.

Cell. 2011 Oct 28;147(3):666-77. doi: 10.1016/j.cell.2011.09.046.


A Chemical Controller of SNARE-Driven Membrane Fusion That Primes Vesicles for Ca(2+)-Triggered Millisecond Exocytosis.

Heo P, Yang Y, Han KY, Kong B, Shin JH, Jung Y, Jeong C, Shin J, Shin YK, Ha T, Kweon DH.

J Am Chem Soc. 2016 Apr 6;138(13):4512-21. doi: 10.1021/jacs.5b13449. Epub 2016 Mar 25.


Neurotransmitter release: the last millisecond in the life of a synaptic vesicle.

Südhof TC.

Neuron. 2013 Oct 30;80(3):675-90. doi: 10.1016/j.neuron.2013.10.022. Review.


Distinct domains of complexin I differentially regulate neurotransmitter release.

Xue M, Reim K, Chen X, Chao HT, Deng H, Rizo J, Brose N, Rosenmund C.

Nat Struct Mol Biol. 2007 Oct;14(10):949-58. Epub 2007 Sep 9.


Dynamic Ca2+-dependent stimulation of vesicle fusion by membrane-anchored synaptotagmin 1.

Lee HK, Yang Y, Su Z, Hyeon C, Lee TS, Lee HW, Kweon DH, Shin YK, Yoon TY.

Science. 2010 May 7;328(5979):760-3. doi: 10.1126/science.1187722.


Preincubation of t-SNAREs with Complexin I Increases Content-Mixing Efficiency.

Kim J, Zhu Y, Shin YK.

Biochemistry. 2016 Jul 5;55(26):3667-73. doi: 10.1021/acs.biochem.6b00114. Epub 2016 Jun 24.


Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release.

Groffen AJ, Martens S, Díez Arazola R, Cornelisse LN, Lozovaya N, de Jong AP, Goriounova NA, Habets RL, Takai Y, Borst JG, Brose N, McMahon HT, Verhage M.

Science. 2010 Mar 26;327(5973):1614-8. doi: 10.1126/science.1183765. Epub 2010 Feb 11. Erratum in: Science. 2010 May 7;328(5979):690.


Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+.

Chicka MC, Hui E, Liu H, Chapman ER.

Nat Struct Mol Biol. 2008 Aug;15(8):827-35. doi: 10.1038/nsmb.1463. Epub 2008 Jul 11.

Supplemental Content

Support Center