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Combination therapy of an inhibitor of group VIA phospholipase A2 with paclitaxel is highly effective in blocking ovarian cancer development.

Li H, Zhao Z, Antalis C, Zhao Z, Emerson R, Wei G, Zhang S, Zhang ZY, Xu Y.

Am J Pathol. 2011 Jul;179(1):452-61. doi: 10.1016/j.ajpath.2011.03.027. Epub 2011 May 17.


Inhibition of Ca2+-independent phospholipase A2 decreases prostate cancer cell growth by p53-dependent and independent mechanisms.

Sun B, Zhang X, Talathi S, Cummings BS.

J Pharmacol Exp Ther. 2008 Jul;326(1):59-68. doi: 10.1124/jpet.108.138958. Epub 2008 Apr 25.


Group VIA phospholipase A2 in both host and tumor cells is involved in ovarian cancer development.

Li H, Zhao Z, Wei G, Yan L, Wang D, Zhang H, Sandusky GE, Turk J, Xu Y.

FASEB J. 2010 Oct;24(10):4103-16. doi: 10.1096/fj.10-161356. Epub 2010 Jun 8. Erratum in: FASEB J. 2015 Jan;29(1):354.


Calcium-independent phospholipase A2 beta is dispensable in inflammasome activation and its inhibition by bromoenol lactone.

Franchi L, Chen G, Marina-Garcia N, Abe A, Qu Y, Bao S, Shayman JA, Turk J, Dubyak GR, Núñez G.

J Innate Immun. 2009;1(6):607-17. doi: 10.1159/000227263.


KSP inhibitor ARRY-520 as a substitute for Paclitaxel in Type I ovarian cancer cells.

Kim KH, Xie Y, Tytler EM, Woessner R, Mor G, Alvero AB.

J Transl Med. 2009 Jul 20;7:63. doi: 10.1186/1479-5876-7-63.


Regulation of PSA secretion and survival signaling by calcium-independent phopholipase A(2)beta in prostate cancer cells.

Nicotera TM, Schuster DP, Bourhim M, Chadha K, Klaich G, Corral DA.

Prostate. 2009 Sep 1;69(12):1270-80. doi: 10.1002/pros.20968.


Aurora kinase A mediates epithelial ovarian cancer cell migration and adhesion.

Do TV, Xiao F, Bickel LE, Klein-Szanto AJ, Pathak HB, Hua X, Howe C, O'Brien SW, Maglaty M, Ecsedy JA, Litwin S, Golemis EA, Schilder RJ, Godwin AK, Connolly DC.

Oncogene. 2014 Jan 30;33(5):539-49. doi: 10.1038/onc.2012.632. Epub 2013 Jan 21.


Lysophosphatidic acid is constitutively produced by human peritoneal mesothelial cells and enhances adhesion, migration, and invasion of ovarian cancer cells.

Ren J, Xiao YJ, Singh LS, Zhao X, Zhao Z, Feng L, Rose TM, Prestwich GD, Xu Y.

Cancer Res. 2006 Mar 15;66(6):3006-14.


Lysophosphatidic acid stimulates cell migration, invasion, and colony formation as well as tumorigenesis/metastasis of mouse ovarian cancer in immunocompetent mice.

Li H, Wang D, Zhang H, Kirmani K, Zhao Z, Steinmetz R, Xu Y.

Mol Cancer Ther. 2009 Jun;8(6):1692-701. doi: 10.1158/1535-7163.MCT-08-1106. Epub 2009 Jun 9.


Bromoenol Lactone Attenuates Nicotine-Induced Breast Cancer Cell Proliferation and Migration.

Calderon LE, Liu S, Arnold N, Breakall B, Rollins J, Ndinguri M.

PLoS One. 2015 Nov 20;10(11):e0143277. doi: 10.1371/journal.pone.0143277. eCollection 2015.


Anti-MUC1 monoclonal antibody (C595) and docetaxel markedly reduce tumor burden and ascites, and prolong survival in an in vivo ovarian cancer model.

Wang L, Chen H, Pourgholami MH, Beretov J, Hao J, Chao H, Perkins AC, Kearsley JH, Li Y.

PLoS One. 2011;6(9):e24405. doi: 10.1371/journal.pone.0024405. Epub 2011 Sep 9.


Proton pump inhibitors enhance the effects of cytotoxic agents in chemoresistant epithelial ovarian carcinoma.

Lee YY, Jeon HK, Hong JE, Cho YJ, Ryu JY, Choi JJ, Lee SH, Yoon G, Kim WY, Do IG, Kim MK, Kim TJ, Choi CH, Lee JW, Bae DS, Kim BG.

Oncotarget. 2015 Oct 27;6(33):35040-50. doi: 10.18632/oncotarget.5319.


Induction of group VIA phospholipase A2 activity during in vitro ischemia in C2C12 myotubes is associated with changes in the level of its splice variants.

Poulsen KA, Pedersen SF, Kolko M, Lambert IH.

Am J Physiol Cell Physiol. 2007 Nov;293(5):C1605-15. Epub 2007 Sep 5.


Metformin inhibits the development and metastasis of ovarian cancer.

Wu B, Li S, Sheng L, Zhu J, Gu L, Shen H, La D, Hambly BD, Bao S, Di W.

Oncol Rep. 2012 Sep;28(3):903-8. doi: 10.3892/or.2012.1890. Epub 2012 Jun 29.


Fibroblasts in omentum activated by tumor cells promote ovarian cancer growth, adhesion and invasiveness.

Cai J, Tang H, Xu L, Wang X, Yang C, Ruan S, Guo J, Hu S, Wang Z.

Carcinogenesis. 2012 Jan;33(1):20-9. doi: 10.1093/carcin/bgr230. Epub 2011 Oct 21.


Interaction between VEGF and calcium-independent phospholipase A2 in proliferation and migration of retinal pigment epithelium.

Kehler AK, Andersen C, Andreasen JR, Vohra R, Junker N, Poulsen KA, Kolko M.

Curr Eye Res. 2012 Jun;37(6):500-7. doi: 10.3109/02713683.2012.663855.


Role of the immunosuppressive enzyme indoleamine 2,3-dioxygenase in the progression of ovarian carcinoma.

Inaba T, Ino K, Kajiyama H, Yamamoto E, Shibata K, Nawa A, Nagasaka T, Akimoto H, Takikawa O, Kikkawa F.

Gynecol Oncol. 2009 Nov;115(2):185-92. doi: 10.1016/j.ygyno.2009.07.015. Epub 2009 Aug 8.


Bromoenol lactone inhibits voltage-gated Ca2+ and transient receptor potential canonical channels.

Chakraborty S, Berwick ZC, Bartlett PJ, Kumar S, Thomas AP, Sturek M, Tune JD, Obukhov AG.

J Pharmacol Exp Ther. 2011 Nov;339(2):329-40. doi: 10.1124/jpet.111.183673. Epub 2011 Jul 27.

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