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Items: 1 to 20 of 73

1.

Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice.

Pasquini S, De Rosa M, Pedani V, Mugnaini C, Guida F, Luongo L, De Chiaro M, Maione S, Dragoni S, Frosini M, Ligresti A, Di Marzo V, Corelli F.

J Med Chem. 2011 Aug 11;54(15):5444-53. doi: 10.1021/jm200476p.

PMID:
21702498
2.

Investigations on the 4-quinolone-3-carboxylic acid motif. 2. Synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic activity in vivo.

Pasquini S, Botta L, Semeraro T, Mugnaini C, Ligresti A, Palazzo E, Maione S, Di Marzo V, Corelli F.

J Med Chem. 2008 Aug 28;51(16):5075-84. doi: 10.1021/jm800552f.

PMID:
18680276
3.

Three-dimensional quantitative structure-selectivity relationships analysis guided rational design of a highly selective ligand for the cannabinoid receptor 2.

Brogi S, Corelli F, Di Marzo V, Ligresti A, Mugnaini C, Pasquini S, Tafi A.

Eur J Med Chem. 2011 Feb;46(2):547-55. doi: 10.1016/j.ejmech.2010.11.034.

PMID:
21183257
4.

Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors.

Pasquini S, De Rosa M, Ligresti A, Mugnaini C, Brizzi A, Caradonna NP, Cascio MG, Bolognini D, Pertwee RG, Di Marzo V, Corelli F.

Eur J Med Chem. 2012 Dec;58:30-43. doi: 10.1016/j.ejmech.2012.09.035.

PMID:
23085772
5.

Investigations on the 4-quinolone-3-carboxylic acid motif. 3. Synthesis, structure-affinity relationships, and pharmacological characterization of 6-substituted 4-quinolone-3-carboxamides as highly selective cannabinoid-2 receptor ligands.

Pasquini S, Ligresti A, Mugnaini C, Semeraro T, Cicione L, De Rosa M, Guida F, Luongo L, De Chiaro M, Cascio MG, Bolognini D, Marini P, Pertwee R, Maione S, Di Marzo V, Corelli F.

J Med Chem. 2010 Aug 26;53(16):5915-28. doi: 10.1021/jm100123x.

PMID:
20718492
6.

Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 7. Synthesis and Pharmacological Evaluation of 4-Quinolone-3-carboxamides and 4-Hydroxy-2-quinolone-3-carboxamides as High Affinity Cannabinoid Receptor 2 (CB2R) Ligands with Improved Aqueous Solubility.

Mugnaini C, Brizzi A, Ligresti A, Allarà M, Lamponi S, Vacondio F, Silva C, Mor M, Di Marzo V, Corelli F.

J Med Chem. 2016 Feb 11;59(3):1052-67. doi: 10.1021/acs.jmedchem.5b01559.

PMID:
26756097
7.

In vitro and in vivo pharmacological characterization of two novel selective cannabinoid CB(2) receptor inverse agonists.

Cascio MG, Bolognini D, Pertwee RG, Palazzo E, Corelli F, Pasquini S, Di Marzo V, Maione S.

Pharmacol Res. 2010 Apr;61(4):349-54. doi: 10.1016/j.phrs.2009.11.011.

PMID:
19961936
8.

Structure-affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist.

Brizzi A, Aiello F, Marini P, Cascio MG, Corelli F, Brizzi V, De Petrocellis L, Ligresti A, Luongo L, Lamponi S, Maione S, Pertwee RG, Di Marzo V.

Bioorg Med Chem. 2014 Sep 1;22(17):4770-83. doi: 10.1016/j.bmc.2014.07.006.

PMID:
25065940
9.

A role for cannabinoid receptors, but not endogenous opioids, in the antinociceptive activity of the CB2-selective agonist, GW405833.

Whiteside GT, Gottshall SL, Boulet JM, Chaffer SM, Harrison JE, Pearson MS, Turchin PI, Mark L, Garrison AE, Valenzano KJ.

Eur J Pharmacol. 2005 Dec 28;528(1-3):65-72.

PMID:
16316650
10.

4-Oxo-1,4-dihydropyridines as selective CB₂ cannabinoid receptor ligands. Part 2: discovery of new agonists endowed with protective effect against experimental colitis.

El Bakali J, Gilleron P, Body-Malapel M, Mansouri R, Muccioli GG, Djouina M, Barczyk A, Klupsch F, Andrzejak V, Lipka E, Furman C, Lambert DM, Chavatte P, Desreumaux P, Millet R.

J Med Chem. 2012 Oct 25;55(20):8948-52. doi: 10.1021/jm3008568.

PMID:
23017078
11.

Synthesis and SAR studies of 2-oxoquinoline derivatives as CB2 receptor inverse agonists.

Raitio KH, Savinainen JR, Vepsäläinen J, Laitinen JT, Poso A, Järvinen T, Nevalainen T.

J Med Chem. 2006 Mar 23;49(6):2022-7.

PMID:
16539390
12.

Investigations on the 4-quinolone-3-carboxylic acid motif part 5: modulation of the physicochemical profile of a set of potent and selective cannabinoid-2 receptor ligands through a bioisosteric approach.

Mugnaini C, Nocerino S, Pedani V, Pasquini S, Tafi A, De Chiaro M, Bellucci L, Valoti M, Guida F, Luongo L, Dragoni S, Ligresti A, Rosenberg A, Bolognini D, Cascio MG, Pertwee RG, Moaddel R, Maione S, Di Marzo V, Corelli F.

ChemMedChem. 2012 May;7(5):920-34. doi: 10.1002/cmdc.201100573.

13.

A novel CB2 agonist, COR167, potently protects rat brain cortical slices against OGD and reperfusion injury.

Contartese A, Valoti M, Corelli F, Pasquini S, Mugnaini C, Pessina F, Aldinucci C, Sgaragli G, Frosini M.

Pharmacol Res. 2012 Dec;66(6):555-63. doi: 10.1016/j.phrs.2012.08.003.

PMID:
23036353
14.

Synthesis, radiolabeling and evaluation of novel 4-oxo-quinoline derivatives as PET tracers for imaging cannabinoid type 2 receptor.

Slavik R, Herde AM, Bieri D, Weber M, Schibli R, Krämer SD, Ametamey SM, Mu L.

Eur J Med Chem. 2015 Mar 6;92:554-64. doi: 10.1016/j.ejmech.2015.01.028.

PMID:
25599952
15.

Development and evaluation of novel PET tracers for imaging cannabinoid receptor type 2 in brain.

Slavik R, Bieri D, Cermak S, Müller A, Krämer SD, Weber M, Schibli R, Ametamey SM, Mu L.

Chimia (Aarau). 2014;68(4):208-10. doi: 10.2533/chimia.2014.208.

PMID:
24983598
16.

Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity.

Khanolkar AD, Lu D, Ibrahim M, Duclos RI Jr, Thakur GA, Malan TP Jr, Porreca F, Veerappan V, Tian X, George C, Parrish DA, Papahatjis DP, Makriyannis A.

J Med Chem. 2007 Dec 27;50(26):6493-500.

PMID:
18038967
17.

The 4-quinolone-3-carboxylic acid motif as a multivalent scaffold in medicinal chemistry.

Mugnaini C, Pasquini S, Corelli F.

Curr Med Chem. 2009;16(14):1746-67. Review.

PMID:
19442143
18.

Pharmacomodulations around the 4-oxo-1,4-dihydroquinoline-3-carboxamides, a class of potent CB2-selective cannabinoid receptor ligands: consequences in receptor affinity and functionality.

Stern E, Muccioli GG, Bosier B, Hamtiaux L, Millet R, Poupaert JH, Hénichart JP, Depreux P, Goossens JF, Lambert DM.

J Med Chem. 2007 Nov 1;50(22):5471-84.

PMID:
17915849
19.

CB2 cannabinoid receptor mediation of antinociception.

Ibrahim MM, Rude ML, Stagg NJ, Mata HP, Lai J, Vanderah TW, Porreca F, Buckley NE, Makriyannis A, Malan TP Jr.

Pain. 2006 May;122(1-2):36-42.

PMID:
16563625
20.

Novel 4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives as new CB2 cannabinoid receptors agonists: synthesis, pharmacological properties and molecular modeling.

Stern E, Muccioli GG, Millet R, Goossens JF, Farce A, Chavatte P, Poupaert JH, Lambert DM, Depreux P, Hénichart JP.

J Med Chem. 2006 Jan 12;49(1):70-9.

PMID:
16392793

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