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Genomic imbalances are confined to non-proliferating cells in paediatric patients with acute myeloid leukaemia and a normal or incomplete karyotype.

Ballabio E, Regan R, Garimberti E, Harbott J, Bradtke J, Teigler-Schlegel A, Biondi A, Cazzaniga G, Giudici G, Wainscoat JS, Boultwood J, Bridger JM, Knight SJ, Tosi S.

PLoS One. 2011;6(6):e20607. doi: 10.1371/journal.pone.0020607. Epub 2011 Jun 9.


Spectral karyotyping and fluorescence in situ hybridization detect novel chromosomal aberrations, a recurring involvement of chromosome 21 and amplification of the MYC oncogene in acute myeloid leukaemia M2.

Hilgenfeld E, Padilla-Nash H, McNeil N, Knutsen T, Montagna C, Tchinda J, Horst J, Ludwig WD, Serve H, Büchner T, Berdel WE, Schröck E, Ried T.

Br J Haematol. 2001 May;113(2):305-17.


Diagnostic value of fluorescence in situ hybridization for the detection of genomic aberrations in older patients with acute myeloid leukemia.

Fröhling S, Kayser S, Mayer C, Miller S, Wieland C, Skelin S, Schlenk RF, Döhner H, Döhner K; AML Study Group Ulm.

Haematologica. 2005 Feb;90(2):194-9.


Detection of karyotype changes in interphase cells: oligonucleotide-primed in situ labelling versus fluorescence in situ hybridization.

Werner M, Wilkens L, Nasarek A, Tchinda J, Komminoth P.

Virchows Arch. 1997 May;430(5):381-7.


DNA copy number changes and immunophenotype pattern in karyotypically normal acute myeloid leukemia patients from an Indian population.

Kawankar N, Korgaonkar S, Kerketta L, Madkaikar M, Jijina F, Ghosh K, Vundinti BR.

Genet Test Mol Biomarkers. 2012 Apr;16(4):265-70. doi: 10.1089/gtmb.2011.0174. Epub 2011 Nov 22.


Genomic Copy Number Variations in the Myelodysplastic Syndrome and Acute Myeloid Leukemia Patients with del(5q) and/or -7/del(7q).

Zhang R, Kim YM, Wang X, Li Y, Lu X, Sternenberger AR, Li S, Lee JY.

Int J Med Sci. 2015 Sep 1;12(9):719-26. doi: 10.7150/ijms.12612. eCollection 2015.


Comparative genomic hybridization-aided unraveling of complex karyotypes in human hematopoietic neoplasias.

Verdorfer I, Brecevic L, Saul W, Schenker B, Kirsch M, Trautmann U, Helm G, Gramatzki M, Gebhart E.

Cancer Genet Cytogenet. 2001 Jan 1;124(1):1-6.


Close correlation of copy number aberrations detected by next-generation sequencing with results from routine cytogenetics in acute myeloid leukemia.

Vosberg S, Herold T, Hartmann L, Neumann M, Opatz S, Metzeler KH, Schneider S, Graf A, Krebs S, Blum H, Baldus CD, Hiddemann W, Spiekermann K, Bohlander SK, Mansmann U, Greif PA.

Genes Chromosomes Cancer. 2016 Jul;55(7):553-67. doi: 10.1002/gcc.22359. Epub 2016 May 2.


Clinical utility of array comparative genomic hybridization for detection of chromosomal abnormalities in pediatric acute lymphoblastic leukemia.

Rabin KR, Man TK, Yu A, Folsom MR, Zhao YJ, Rao PH, Plon SE, Naeem RC.

Pediatr Blood Cancer. 2008 Aug;51(2):171-7. doi: 10.1002/pbc.21488.


A cryptic t(5;11)(q35;p15.5) in 2 children with acute myeloid leukemia with apparently normal karyotypes, identified by a multiplex fluorescence in situ hybridization telomere assay.

Brown J, Jawad M, Twigg SR, Saracoglu K, Sauerbrey A, Thomas AE, Eils R, Harbott J, Kearney L.

Blood. 2002 Apr 1;99(7):2526-31.


Delineation of yet unknown cryptic subtelomere aberrations in 50% of acute myeloid leukemia with normal GTG-banding karyotype.

Gross M, Mkrtchyan H, Glaser M, Fricke HJ, Höffken K, Heller A, Weise A, Liehr T.

Int J Oncol. 2009 Feb;34(2):417-23.


Design and validation of DNA probe sets for a comprehensive interphase cytogenetic analysis of acute myeloid leukemia.

Fischer K, Scholl C, Sàlat J, Fröhling S, Schlenk R, Bentz M, Stilgenbauer S, Lichter P, Döhner H.

Blood. 1996 Nov 15;88(10):3962-71.


Comparative genomic hybridization and multiplex-fluorescence in situ hybridization: an appraisal in elderly patients with acute myelogenous leukemia.

Dalley CD, Neat MJ, Foot NJ, Burridge M, Byrne L, Amess JA, Rohatiner AZ, Lister A, Young BD, Lillington DM.

Hematol J. 2002;3(6):290-8.


A new classification of interphase nuclei based on spatial organizations of chromosome 8 and 21 for t(8;21) (q22;q22) acute myeloid leukemia by three-dimensional fluorescence in situ hybridization.

Tian X, Wang Y, Zhao F, Liu J, Yin J, Chen D, Ma W, Ke X.

Leuk Res. 2015 Dec;39(12):1414-20. doi: 10.1016/j.leukres.2015.09.013. Epub 2015 Sep 18.


In situ hybridization to interphase nuclei in acute leukemia.

Romana SP, Cherif D, Le Coniat M, Derré J, Flexor MA, Berger R.

Genes Chromosomes Cancer. 1993 Oct;8(2):98-103.


Integration of microarray analysis into the clinical diagnosis of hematological malignancies: How much can we improve cytogenetic testing?

Peterson JF, Aggarwal N, Smith CA, Gollin SM, Surti U, Rajkovic A, Swerdlow SH, Yatsenko SA.

Oncotarget. 2015 Aug 7;6(22):18845-62.

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