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Items: 1 to 20 of 160

1.

Outbred ICR/CD1 mice display more severe neuroinflammation mediated by microglial TLR4/CD14 activation than inbred C57Bl/6 mice.

Nikodemova M, Watters JJ.

Neuroscience. 2011 Sep 8;190:67-74. doi: 10.1016/j.neuroscience.2011.06.006. Epub 2011 Jun 13.

2.

A requirement for microglial TLR4 in leukocyte recruitment into brain in response to lipopolysaccharide.

Zhou H, Lapointe BM, Clark SR, Zbytnuik L, Kubes P.

J Immunol. 2006 Dec 1;177(11):8103-10.

3.

GM-CSF increases LPS-induced production of proinflammatory mediators via upregulation of TLR4 and CD14 in murine microglia.

Parajuli B, Sonobe Y, Kawanokuchi J, Doi Y, Noda M, Takeuchi H, Mizuno T, Suzumura A.

J Neuroinflammation. 2012 Dec 13;9:268. doi: 10.1186/1742-2094-9-268.

4.

Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response.

O'Callaghan P, Li JP, Lannfelt L, Lindahl U, Zhang X.

J Biol Chem. 2015 Jun 12;290(24):14904-14. doi: 10.1074/jbc.M114.634337. Epub 2015 Apr 13.

5.

Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice.

Wohleb ES, Fenn AM, Pacenta AM, Powell ND, Sheridan JF, Godbout JP.

Psychoneuroendocrinology. 2012 Sep;37(9):1491-505. doi: 10.1016/j.psyneuen.2012.02.003. Epub 2012 Mar 2.

6.

Autotaxin downregulates LPS-induced microglia activation and pro-inflammatory cytokines production.

Awada R, Saulnier-Blache JS, Grès S, Bourdon E, Rondeau P, Parimisetty A, Orihuela R, Harry GJ, d'Hellencourt CL.

J Cell Biochem. 2014 Dec;115(12):2123-32. doi: 10.1002/jcb.24889.

7.

Absence of CD14 delays progression of prion diseases accompanied by increased microglial activation.

Sakai K, Hasebe R, Takahashi Y, Song CH, Suzuki A, Yamasaki T, Horiuchi M.

J Virol. 2013 Dec;87(24):13433-45. doi: 10.1128/JVI.02072-13. Epub 2013 Oct 2.

8.
9.

Protosappanin A inhibits oxidative and nitrative stress via interfering the interaction of transmembrane protein CD14 with Toll-like receptor-4 in lipopolysaccharide-induced BV-2 microglia.

Zeng KW, Zhao MB, Ma ZZ, Jiang Y, Tu PF.

Int Immunopharmacol. 2012 Dec;14(4):558-69. doi: 10.1016/j.intimp.2012.09.004. Epub 2012 Sep 21.

PMID:
23000519
10.

Chronic intermittent hypoxia exerts CNS region-specific effects on rat microglial inflammatory and TLR4 gene expression.

Smith SM, Friedle SA, Watters JJ.

PLoS One. 2013 Dec 4;8(12):e81584. doi: 10.1371/journal.pone.0081584. eCollection 2013.

11.

Hyperoxia-induced immature brain injury through the TLR4 signaling pathway in newborn mice.

Liu Y, Jiang P, Du M, Chen K, Chen A, Wang Y, Cao F, Deng S, Xu Y.

Brain Res. 2015 Jun 12;1610:51-60. doi: 10.1016/j.brainres.2015.03.021. Epub 2015 Mar 21.

PMID:
25801121
12.

Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury.

Jeyaseelan S, Chu HW, Young SK, Freeman MW, Worthen GS.

Infect Immun. 2005 Mar;73(3):1754-63.

13.

TLR4, but not TLR2, signals autoregulatory apoptosis of cultured microglia: a critical role of IFN-beta as a decision maker.

Jung DY, Lee H, Jung BY, Ock J, Lee MS, Lee WH, Suk K.

J Immunol. 2005 May 15;174(10):6467-76.

14.

Efficient isolation of live microglia with preserved phenotypes from adult mouse brain.

Nikodemova M, Watters JJ.

J Neuroinflammation. 2012 Jun 28;9:147. doi: 10.1186/1742-2094-9-147.

15.

Anti-inflammatory mechanisms of N-adamantyl-4-methylthiazol-2-amine in lipopolysaccharide-stimulated BV-2 microglial cells.

Kim EA, Han AR, Choi J, Ahn JY, Choi SY, Cho SW.

Int Immunopharmacol. 2014 Sep;22(1):73-83. doi: 10.1016/j.intimp.2014.06.022. Epub 2014 Jun 25.

PMID:
24975832
16.

Age-dependent differences in microglial responses to systemic inflammation are evident as early as middle age.

Nikodemova M, Small AL, Kimyon RS, Watters JJ.

Physiol Genomics. 2016 May;48(5):336-44. doi: 10.1152/physiolgenomics.00129.2015. Epub 2016 Feb 16.

17.

CD14 and TRIF govern distinct responsiveness and responses in mouse microglial TLR4 challenges by structural variants of LPS.

Regen T, van Rossum D, Scheffel J, Kastriti ME, Revelo NH, Prinz M, Brück W, Hanisch UK.

Brain Behav Immun. 2011 Jul;25(5):957-70. doi: 10.1016/j.bbi.2010.10.009. Epub 2010 Oct 15.

PMID:
20951794
18.

Pseudoginsenoside-F11 (PF11) exerts anti-neuroinflammatory effects on LPS-activated microglial cells by inhibiting TLR4-mediated TAK1/IKK/NF-κB, MAPKs and Akt signaling pathways.

Wang X, Wang C, Wang J, Zhao S, Zhang K, Wang J, Zhang W, Wu C, Yang J.

Neuropharmacology. 2014 Apr;79:642-56. doi: 10.1016/j.neuropharm.2014.01.022. Epub 2014 Jan 24.

PMID:
24467851
19.

Astrocytic Orosomucoid-2 Modulates Microglial Activation and Neuroinflammation.

Jo M, Kim JH, Song GJ, Seo M, Hwang EM, Suk K.

J Neurosci. 2017 Mar 15;37(11):2878-2894. doi: 10.1523/JNEUROSCI.2534-16.2017. Epub 2017 Feb 13.

20.

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