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Items: 1 to 20 of 74

1.

Transmigration of beta amyloid specific heavy chain antibody fragments across the in vitro blood-brain barrier.

Rutgers KS, Nabuurs RJ, van den Berg SA, Schenk GJ, Rotman M, Verrips CT, van Duinen SG, Maat-Schieman ML, van Buchem MA, de Boer AG, van der Maarel SM.

Neuroscience. 2011 Sep 8;190:37-42. doi: 10.1016/j.neuroscience.2011.05.076. Epub 2011 Jun 13.

PMID:
21683126
2.

Enhanced glutathione PEGylated liposomal brain delivery of an anti-amyloid single domain antibody fragment in a mouse model for Alzheimer's disease.

Rotman M, Welling MM, Bunschoten A, de Backer ME, Rip J, Nabuurs RJ, Gaillard PJ, van Buchem MA, van der Maarel SM, van der Weerd L.

J Control Release. 2015 Apr 10;203:40-50. doi: 10.1016/j.jconrel.2015.02.012. Epub 2015 Feb 7.

PMID:
25668771
3.

In vivo detection of amyloid-β deposits using heavy chain antibody fragments in a transgenic mouse model for Alzheimer's disease.

Nabuurs RJ, Rutgers KS, Welling MM, Metaxas A, de Backer ME, Rotman M, Bacskai BJ, van Buchem MA, van der Maarel SM, van der Weerd L.

PLoS One. 2012;7(6):e38284. doi: 10.1371/journal.pone.0038284. Epub 2012 Jun 4.

4.

Fusion of hIgG1-Fc to 111In-anti-amyloid single domain antibody fragment VHH-pa2H prolongs blood residential time in APP/PS1 mice but does not increase brain uptake.

Rotman M, Welling MM, van den Boogaard ML, Moursel LG, van der Graaf LM, van Buchem MA, van der Maarel SM, van der Weerd L.

Nucl Med Biol. 2015 Aug;42(8):695-702. doi: 10.1016/j.nucmedbio.2015.03.003. Epub 2015 Mar 18.

5.

Epitope-dependent effects of Beta-amyloid antibodies on Beta-amyloid clearance in an in vitro model of the blood-brain barrier.

Bachmeier CJ, Beaulieu-Abdelahad D, Mullan MJ, Paris D.

Microcirculation. 2011 Jul;18(5):373-9. doi: 10.1111/j.1549-8719.2011.00096.x.

PMID:
21418385
6.

The role of the ATP-binding cassette transporter P-glycoprotein in the transport of β-amyloid across the blood-brain barrier.

Vogelgesang S, Jedlitschky G, Brenn A, Walker LC.

Curr Pharm Des. 2011;17(26):2778-86. Review.

PMID:
21827406
8.

Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions.

Mackic JB, Bading J, Ghiso J, Walker L, Wisniewski T, Frangione B, Zlokovic BV.

Vascul Pharmacol. 2002 Jun;38(6):303-13.

PMID:
12529925
9.

Design and evaluation of a 6-mer amyloid-beta protein derived phage display library for molecular targeting of amyloid plaques in Alzheimer's disease: Comparison with two cyclic heptapeptides derived from a randomized phage display library.

Larbanoix L, Burtea C, Ansciaux E, Laurent S, Mahieu I, Vander Elst L, Muller RN.

Peptides. 2011 Jun;32(6):1232-43. doi: 10.1016/j.peptides.2011.04.026. Epub 2011 May 6.

PMID:
21575663
10.

Blood-brain-barrier models for the investigation of transporter- and receptor-mediated amyloid-β clearance in Alzheimer's disease.

Pflanzner T, Kuhlmann CR, Pietrzik CU.

Curr Alzheimer Res. 2010 Nov;7(7):578-90. Review.

PMID:
20704558
12.

In vivo targeting of antibody fragments to the nervous system for Alzheimer's disease immunotherapy and molecular imaging of amyloid plaques.

Poduslo JF, Ramakrishnan M, Holasek SS, Ramirez-Alvarado M, Kandimalla KK, Gilles EJ, Curran GL, Wengenack TM.

J Neurochem. 2007 Jul;102(2):420-33.

13.

Quinoline-n-butylcyanoacrylate-based nanoparticles for brain targeting for the diagnosis of Alzheimer's disease.

Kulkarni PV, Roney CA, Antich PP, Bonte FJ, Raghu AV, Aminabhavi TM.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2010 Jan-Feb;2(1):35-47. doi: 10.1002/wnan.59. Review.

PMID:
20049829
14.

[Role of the blood-brain barrier in Alzheimer's disease].

Gosselet F, Candela P, Cecchelli R, Fenart L.

Med Sci (Paris). 2011 Nov;27(11):987-92. doi: 10.1051/medsci/20112711015. Epub 2011 Nov 30. Review. French.

15.

Cell-penetrating anti-GFAP VHH and corresponding fluorescent fusion protein VHH-GFP spontaneously cross the blood-brain barrier and specifically recognize astrocytes: application to brain imaging.

Li T, Bourgeois JP, Celli S, Glacial F, Le Sourd AM, Mecheri S, Weksler B, Romero I, Couraud PO, Rougeon F, Lafaye P.

FASEB J. 2012 Oct;26(10):3969-79. doi: 10.1096/fj.11-201384. Epub 2012 Jun 22.

PMID:
22730440
17.
18.

Method for measurement of the blood-brain barrier permeability in the perfused mouse brain: application to amyloid-beta peptide in wild type and Alzheimer's Tg2576 mice.

LaRue B, Hogg E, Sagare A, Jovanovic S, Maness L, Maurer C, Deane R, Zlokovic BV.

J Neurosci Methods. 2004 Sep 30;138(1-2):233-42.

PMID:
15325132
19.

Blood-brain barrier transport of circulating Alzheimer's amyloid beta.

Zlokovic BV, Ghiso J, Mackic JB, McComb JG, Weiss MH, Frangione B.

Biochem Biophys Res Commun. 1993 Dec 30;197(3):1034-40.

PMID:
8280117
20.

The blood-brain barrier in Alzheimer's disease.

Vinters HV, Pardridge WM.

Can J Neurol Sci. 1986 Nov;13(4 Suppl):446-8.

PMID:
2947668

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