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Items: 1 to 20 of 164

1.

Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis.

Fukata M, Shang L, Santaolalla R, Sotolongo J, Pastorini C, España C, Ungaro R, Harpaz N, Cooper HS, Elson G, Kosco-Vilbois M, Zaias J, Perez MT, Mayer L, Vamadevan AS, Lira SA, Abreu MT.

Inflamm Bowel Dis. 2011 Jul;17(7):1464-73. doi: 10.1002/ibd.21527. Epub 2010 Nov 15.

2.

The role of prostaglandin E2 (PGE 2) in toll-like receptor 4 (TLR4)-mediated colitis-associated neoplasia.

Hernandez Y, Sotolongo J, Breglio K, Conduah D, Chen A, Xu R, Hsu D, Ungaro R, Hayes LA, Pastorini C, Abreu MT, Fukata M.

BMC Gastroenterol. 2010 Jul 16;10:82. doi: 10.1186/1471-230X-10-82.

3.

Epithelial vanin-1 controls inflammation-driven carcinogenesis in the colitis-associated colon cancer model.

Pouyet L, Roisin-Bouffay C, Clément A, Millet V, Garcia S, Chasson L, Issaly N, Rostan A, Hofman P, Naquet P, Galland F.

Inflamm Bowel Dis. 2010 Jan;16(1):96-104. doi: 10.1002/ibd.21031.

PMID:
19572375
4.

RNase-L deficiency exacerbates experimental colitis and colitis-associated cancer.

Long TM, Chakrabarti A, Ezelle HJ, Brennan-Laun SE, Raufman JP, Polyakova I, Silverman RH, Hassel BA.

Inflamm Bowel Dis. 2013 May;19(6):1295-305. doi: 10.1097/MIB.0b013e318281f2fd.

5.

Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine.

Fukata M, Chen A, Klepper A, Krishnareddy S, Vamadevan AS, Thomas LS, Xu R, Inoue H, Arditi M, Dannenberg AJ, Abreu MT.

Gastroenterology. 2006 Sep;131(3):862-77.

6.

A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis.

Ungaro R, Fukata M, Hsu D, Hernandez Y, Breglio K, Chen A, Xu R, Sotolongo J, Espana C, Zaias J, Elson G, Mayer L, Kosco-Vilbois M, Abreu MT.

Am J Physiol Gastrointest Liver Physiol. 2009 Jun;296(6):G1167-79. doi: 10.1152/ajpgi.90496.2008. Epub 2009 Apr 9.

7.

Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors.

Fukata M, Chen A, Vamadevan AS, Cohen J, Breglio K, Krishnareddy S, Hsu D, Xu R, Harpaz N, Dannenberg AJ, Subbaramaiah K, Cooper HS, Itzkowitz SH, Abreu MT.

Gastroenterology. 2007 Dec;133(6):1869-81. Epub 2007 Sep 14.

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10.

TLR4 activates the β-catenin pathway to cause intestinal neoplasia.

Santaolalla R, Sussman DA, Ruiz JR, Davies JM, Pastorini C, España CL, Sotolongo J, Burlingame O, Bejarano PA, Philip S, Ahmed MM, Ko J, Dirisina R, Barrett TA, Shang L, Lira SA, Fukata M, Abreu MT.

PLoS One. 2013 May 14;8(5):e63298. doi: 10.1371/journal.pone.0063298. Print 2013.

11.

Oroxylin A inhibits colitis-associated carcinogenesis through modulating the IL-6/STAT3 signaling pathway.

Yang X, Zhang F, Wang Y, Cai M, Wang Q, Guo Q, Li Z, Hu R.

Inflamm Bowel Dis. 2013 Aug;19(9):1990-2000. doi: 10.1097/MIB.0b013e318293c5e0.

PMID:
23823704
12.

Altered gut microbiota promotes colitis-associated cancer in IL-1 receptor-associated kinase M-deficient mice.

Klimesova K, Kverka M, Zakostelska Z, Hudcovic T, Hrncir T, Stepankova R, Rossmann P, Ridl J, Kostovcik M, Mrazek J, Kopecny J, Kobayashi KS, Tlaskalova-Hogenova H.

Inflamm Bowel Dis. 2013 May;19(6):1266-77. doi: 10.1097/MIB.0b013e318281330a.

13.

Bifidobacterium lactis inhibits NF-kappaB in intestinal epithelial cells and prevents acute colitis and colitis-associated colon cancer in mice.

Kim SW, Kim HM, Yang KM, Kim SA, Kim SK, An MJ, Park JJ, Lee SK, Kim TI, Kim WH, Cheon JH.

Inflamm Bowel Dis. 2010 Sep;16(9):1514-25. doi: 10.1002/ibd.21262.

PMID:
20310012
14.

Regulation of epithelial cell expressed C3 in the intestine - Relevance for the pathophysiology of inflammatory bowel disease?

Sünderhauf A, Skibbe K, Preisker S, Ebbert K, Verschoor A, Karsten CM, Kemper C, Huber-Lang M, Basic M, Bleich A, Büning J, Fellermann K, Sina C, Derer S.

Mol Immunol. 2017 Oct;90:227-238. doi: 10.1016/j.molimm.2017.08.003. Epub 2017 Aug 24.

PMID:
28843904
15.

Intestinal Epithelial Toll-Like Receptor 4 Signaling Affects Epithelial Function and Colonic Microbiota and Promotes a Risk for Transmissible Colitis.

Dheer R, Santaolalla R, Davies JM, Lang JK, Phillips MC, Pastorini C, Vazquez-Pertejo MT, Abreu MT.

Infect Immun. 2016 Jan 11;84(3):798-810. doi: 10.1128/IAI.01374-15.

16.

Human Colon Tumors Express a Dominant-Negative Form of SIGIRR That Promotes Inflammation and Colitis-Associated Colon Cancer in Mice.

Zhao J, Bulek K, Gulen MF, Zepp JA, Karagkounis G, Martin BN, Zhou H, Yu M, Liu X, Huang E, Fox PL, Kalady MF, Markowitz SD, Li X.

Gastroenterology. 2015 Dec;149(7):1860-1871.e8. doi: 10.1053/j.gastro.2015.08.051. Epub 2015 Sep 5.

17.

Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis.

Popivanova BK, Kitamura K, Wu Y, Kondo T, Kagaya T, Kaneko S, Oshima M, Fujii C, Mukaida N.

J Clin Invest. 2008 Feb;118(2):560-70. doi: 10.1172/JCI32453.

18.

EGFR in Tumor-Associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients.

Srivatsa S, Paul MC, Cardone C, Holcmann M, Amberg N, Pathria P, Diamanti MA, Linder M, Timelthaler G, Dienes HP, Kenner L, Wrba F, Prager GW, Rose-John S, Eferl R, Liguori G, Botti G, Martinelli E, Greten FR, Ciardiello F, Sibilia M.

Gastroenterology. 2017 Jul;153(1):178-190.e10. doi: 10.1053/j.gastro.2017.03.053. Epub 2017 Apr 9.

19.

Involvement of nitric oxide with activation of Toll-like receptor 4 signaling in mice with dextran sodium sulfate-induced colitis.

Tun X, Yasukawa K, Yamada K.

Free Radic Biol Med. 2014 Sep;74:108-17. doi: 10.1016/j.freeradbiomed.2014.06.020. Epub 2014 Jun 30.

PMID:
24992835
20.

Nicotine suppresses acute colitis and colonic tumorigenesis associated with chronic colitis in mice.

Hayashi S, Hamada T, Zaidi SF, Oshiro M, Lee J, Yamamoto T, Ishii Y, Sasahara M, Kadowaki M.

Am J Physiol Gastrointest Liver Physiol. 2014 Nov 15;307(10):G968-78. doi: 10.1152/ajpgi.00346.2013. Epub 2014 Sep 25.

PMID:
25258409

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