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Human defensins 5 and 6 enhance HIV-1 infectivity through promoting HIV attachment.

Rapista A, Ding J, Benito B, Lo YT, Neiditch MB, Lu W, Chang TL.

Retrovirology. 2011 Jun 14;8:45. doi: 10.1186/1742-4690-8-45.


Key Determinants of Human α-Defensin 5 and 6 for Enhancement of HIV Infectivity.

Valere K, Lu W, Chang TL.

Viruses. 2017 Aug 29;9(9). pii: E244. doi: 10.3390/v9090244.


Neisseria gonorrhoeae-induced human defensins 5 and 6 increase HIV infectivity: role in enhanced transmission.

Klotman ME, Rapista A, Teleshova N, Micsenyi A, Jarvis GA, Lu W, Porter E, Chang TL.

J Immunol. 2008 May 1;180(9):6176-85.


Mucosal human defensins 5 and 6 antagonize the anti-HIV activity of candidate polyanion microbicides.

Ding J, Rapista A, Teleshova N, Lu W, Klotman ME, Chang TL.

J Innate Immun. 2011;3(2):208-12. doi: 10.1159/000322355. Epub 2010 Dec 16.


Anti-HIV activity of human defensin 5 in primary CD4+ T cells under serum-deprived conditions is a consequence of defensin-mediated cytotoxicity.

Ding J, Tasker C, Valere K, Sihvonen T, Descalzi-Montoya DB, Lu W, Chang TL.

PLoS One. 2013 Sep 25;8(9):e76038. doi: 10.1371/journal.pone.0076038. eCollection 2013.


Human alpha- and beta-defensins block multiple steps in herpes simplex virus infection.

Hazrati E, Galen B, Lu W, Wang W, Ouyang Y, Keller MJ, Lehrer RI, Herold BC.

J Immunol. 2006 Dec 15;177(12):8658-66.


Enhancement of antiviral activity of human alpha-defensin 5 against herpes simplex virus 2 by arginine mutagenesis at adaptive evolution sites.

Wang A, Chen F, Wang Y, Shen M, Xu Y, Hu J, Wang S, Geng F, Wang C, Ran X, Su Y, Cheng T, Wang J.

J Virol. 2013 Mar;87(5):2835-45. doi: 10.1128/JVI.02209-12. Epub 2012 Dec 26.


Human Alpha-Defensin HNP1 Increases HIV Traversal of the Epithelial Barrier: A Potential Role in STI-Mediated Enhancement of HIV Transmission.

Valere K, Rapista A, Eugenin E, Lu W, Chang TL.

Viral Immunol. 2015 Dec;28(10):609-15. doi: 10.1089/vim.2014.0137. Epub 2015 Sep 17.


Studies on the Interaction of Tumor-Derived HD5 Alpha Defensins with Adenoviruses and Implications for Oncolytic Adenovirus Therapy.

Vragniau C, Hübner JM, Beidler P, Gil S, Saydaminova K, Lu ZZ, Yumul R, Wang H, Richter M, Sova P, Drescher C, Fender P, Lieber A.

J Virol. 2017 Feb 28;91(6). pii: e02030-16. doi: 10.1128/JVI.02030-16. Print 2017 Mar 15.


Human alpha-defensins inhibit BK virus infection by aggregating virions and blocking binding to host cells.

Dugan AS, Maginnis MS, Jordan JA, Gasparovic ML, Manley K, Page R, Williams G, Porter E, O'Hara BA, Atwood WJ.

J Biol Chem. 2008 Nov 7;283(45):31125-32. doi: 10.1074/jbc.M805902200. Epub 2008 Sep 9.


Differential expression of human alpha- and beta-defensins mRNA in gastrointestinal epithelia.

Frye M, Bargon J, Lembcke B, Wagner TO, Gropp R.

Eur J Clin Invest. 2000 Aug;30(8):695-701.


Intestinal alpha-defensin expression in pediatric inflammatory bowel disease.

Zilbauer M, Jenke A, Wenzel G, Goedde D, Postberg J, Phillips AD, Lucas M, Noble-Jamieson G, Torrente F, Salvestrini C, Heuschkel R, Wirth S.

Inflamm Bowel Dis. 2011 Oct;17(10):2076-86. doi: 10.1002/ibd.21577. Epub 2010 Dec 16.


Reduced Human α-defensin 6 in Noninflamed Jejunal Tissue of Patients with Crohn's Disease.

Hayashi R, Tsuchiya K, Fukushima K, Horita N, Hibiya S, Kitagaki K, Negi M, Itoh E, Akashi T, Eishi Y, Okada E, Araki A, Ohtsuka K, Fukuda S, Ohno H, Okamoto R, Nakamura T, Tanaka S, Chayama K, Watanabe M.

Inflamm Bowel Dis. 2016 May;22(5):1119-28. doi: 10.1097/MIB.0000000000000707.


Alpha-defensin HD5 inhibits furin cleavage of human papillomavirus 16 L2 to block infection.

Wiens ME, Smith JG.

J Virol. 2015 Mar;89(5):2866-74. doi: 10.1128/JVI.02901-14. Epub 2014 Dec 24.


Reduced gene expression of intestinal alpha-defensins predicts diarrhea in a cohort of African adults.

Kelly P, Bajaj-Elliott M, Katubulushi M, Zulu I, Poulsom R, Feldman RA, Bevins CL, Dhaliwal W.

J Infect Dis. 2006 May 15;193(10):1464-70. Epub 2006 Apr 12.


Crystal structures of human alpha-defensins HNP4, HD5, and HD6.

Szyk A, Wu Z, Tucker K, Yang D, Lu W, Lubkowski J.

Protein Sci. 2006 Dec;15(12):2749-60. Epub 2006 Nov 6.


α-Defensin HD5 Inhibits Human Papillomavirus 16 Infection via Capsid Stabilization and Redirection to the Lysosome.

Wiens ME, Smith JG.

MBio. 2017 Jan 24;8(1). pii: e02304-16. doi: 10.1128/mBio.02304-16.


Human beta-defensins 2 and -3 cointernalize with human immunodeficiency virus via heparan sulfate proteoglycans and reduce infectivity of intracellular virions in tonsil epithelial cells.

Herrera R, Morris M, Rosbe K, Feng Z, Weinberg A, Tugizov S.

Virology. 2016 Jan;487:172-87. doi: 10.1016/j.virol.2015.09.025. Epub 2015 Nov 2.


Multivalent binding of carbohydrates by the human alpha-defensin, HD5.

Lehrer RI, Jung G, Ruchala P, Andre S, Gabius HJ, Lu W.

J Immunol. 2009 Jul 1;183(1):480-90. doi: 10.4049/jimmunol.0900244.

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