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Analysis of the HD-GYP domain cyclic dimeric GMP phosphodiesterase reveals a role in motility and the enzootic life cycle of Borrelia burgdorferi.

Sultan SZ, Pitzer JE, Boquoi T, Hobbs G, Miller MR, Motaleb MA.

Infect Immun. 2011 Aug;79(8):3273-83. doi: 10.1128/IAI.05153-11. Epub 2011 Jun 13.


Analysis of a Borrelia burgdorferi phosphodiesterase demonstrates a role for cyclic-di-guanosine monophosphate in motility and virulence.

Sultan SZ, Pitzer JE, Miller MR, Motaleb MA.

Mol Microbiol. 2010 Jul 1;77(1):128-42. doi: 10.1111/j.1365-2958.2010.07191.x. Epub 2010 Apr 27.


The cyclic-di-GMP signaling pathway in the Lyme disease spirochete, Borrelia burgdorferi.

Novak EA, Sultan SZ, Motaleb MA.

Front Cell Infect Microbiol. 2014 May 1;4:56. doi: 10.3389/fcimb.2014.00056. eCollection 2014. Review.


A systematic analysis of the in vitro and in vivo functions of the HD-GYP domain proteins of Vibrio cholerae.

McKee RW, Kariisa A, Mudrak B, Whitaker C, Tamayo R.

BMC Microbiol. 2014 Oct 25;14:272. doi: 10.1186/s12866-014-0272-9.


Analysis of the Borrelia burgdorferi cyclic-di-GMP-binding protein PlzA reveals a role in motility and virulence.

Pitzer JE, Sultan SZ, Hayakawa Y, Hobbs G, Miller MR, Motaleb MA.

Infect Immun. 2011 May;79(5):1815-25. doi: 10.1128/IAI.00075-11. Epub 2011 Feb 28. Erratum in: Infect Immun. 2011 Jun;79(6):2499.


The structure of an unconventional HD-GYP protein from Bdellovibrio reveals the roles of conserved residues in this class of cyclic-di-GMP phosphodiesterases.

Lovering AL, Capeness MJ, Lambert C, Hobley L, Sockett RE.

MBio. 2011 Oct 11;2(5). pii: e00163-11. doi: 10.1128/mBio.00163-11. Print 2011.


The diguanylate cyclase, Rrp1, regulates critical steps in the enzootic cycle of the Lyme disease spirochetes.

Kostick JL, Szkotnicki LT, Rogers EA, Bocci P, Raffaelli N, Marconi RT.

Mol Microbiol. 2011 Jul;81(1):219-31. doi: 10.1111/j.1365-2958.2011.07687.x. Epub 2011 Jun 5.


PdeB, a cyclic Di-GMP-specific phosphodiesterase that regulates Shewanella oneidensis MR-1 motility and biofilm formation.

Chao L, Rakshe S, Leff M, Spormann AM.

J Bacteriol. 2013 Sep;195(17):3827-33. doi: 10.1128/JB.00498-13. Epub 2013 Jun 21.


Cyclic di-GMP is essential for the survival of the lyme disease spirochete in ticks.

He M, Ouyang Z, Troxell B, Xu H, Moh A, Piesman J, Norgard MV, Gomelsky M, Yang XF.

PLoS Pathog. 2011 Jun;7(6):e1002133. doi: 10.1371/journal.ppat.1002133. Epub 2011 Jun 30.


Identification and molecular characterization of a cyclic-di-GMP effector protein, PlzA (BB0733): additional evidence for the existence of a functional cyclic-di-GMP regulatory network in the Lyme disease spirochete, Borrelia burgdorferi.

Freedman JC, Rogers EA, Kostick JL, Zhang H, Iyer R, Schwartz I, Marconi RT.

FEMS Immunol Med Microbiol. 2010 Mar;58(2):285-94. doi: 10.1111/j.1574-695X.2009.00635.x. Epub 2009 Nov 23.


Crystal structure of an HD-GYP domain cyclic-di-GMP phosphodiesterase reveals an enzyme with a novel trinuclear catalytic iron centre.

Bellini D, Caly DL, McCarthy Y, Bumann M, An SQ, Dow JM, Ryan RP, Walsh MA.

Mol Microbiol. 2014 Jan;91(1):26-38. doi: 10.1111/mmi.12447. Epub 2013 Nov 24.


Comprehensive overexpression analysis of cyclic-di-GMP signalling proteins in the phytopathogen Pectobacterium atrosepticum reveals diverse effects on motility and virulence phenotypes.

Tan H, West JA, Ramsay JP, Monson RE, Griffin JL, Toth IK, Salmond GP.

Microbiology. 2014 Jul;160(Pt 7):1427-39. doi: 10.1099/mic.0.076828-0. Epub 2014 Apr 23.


The hybrid histidine kinase Hk1 is part of a two-component system that is essential for survival of Borrelia burgdorferi in feeding Ixodes scapularis ticks.

Caimano MJ, Kenedy MR, Kairu T, Desrosiers DC, Harman M, Dunham-Ems S, Akins DR, Pal U, Radolf JD.

Infect Immun. 2011 Aug;79(8):3117-30. doi: 10.1128/IAI.05136-11. Epub 2011 May 23.


Cyclic di-GMP modulates gene expression in Lyme disease spirochetes at the tick-mammal interface to promote spirochete survival during the blood meal and tick-to-mammal transmission.

Caimano MJ, Dunham-Ems S, Allard AM, Cassera MB, Kenedy M, Radolf JD.

Infect Immun. 2015 Aug;83(8):3043-60. doi: 10.1128/IAI.00315-15. Epub 2015 May 18.


Borrelia burgdorferi needs chemotaxis to establish infection in mammals and to accomplish its enzootic cycle.

Sze CW, Zhang K, Kariu T, Pal U, Li C.

Infect Immun. 2012 Jul;80(7):2485-92. doi: 10.1128/IAI.00145-12. Epub 2012 Apr 16.


Brucella melitensis cyclic di-GMP phosphodiesterase BpdA controls expression of flagellar genes.

Petersen E, Chaudhuri P, Gourley C, Harms J, Splitter G.

J Bacteriol. 2011 Oct;193(20):5683-91. doi: 10.1128/JB.00428-11. Epub 2011 Aug 19.


Phenotype overlap in Xylella fastidiosa is controlled by the cyclic di-GMP phosphodiesterase Eal in response to antibiotic exposure and diffusible signal factor-mediated cell-cell signaling.

de Souza AA, Ionescu M, Baccari C, da Silva AM, Lindow SE.

Appl Environ Microbiol. 2013 Jun;79(11):3444-54. doi: 10.1128/AEM.03834-12. Epub 2013 Mar 29.


Systematic analysis of cyclic di-GMP signalling enzymes and their role in biofilm formation and virulence in Yersinia pestis.

Bobrov AG, Kirillina O, Ryjenkov DA, Waters CM, Price PA, Fetherston JD, Mack D, Goldman WE, Gomelsky M, Perry RD.

Mol Microbiol. 2011 Jan;79(2):533-51. doi: 10.1111/j.1365-2958.2010.07470.x. Epub 2010 Dec 3.


HD-GYP domain proteins regulate biofilm formation and virulence in Pseudomonas aeruginosa.

Ryan RP, Lucey J, O'Donovan K, McCarthy Y, Yang L, Tolker-Nielsen T, Dow JM.

Environ Microbiol. 2009 May;11(5):1126-36. doi: 10.1111/j.1462-2920.2008.01842.x. Epub 2008 Dec 17. Erratum in: Environ Microbiol. 2016 Feb;18(2):736.


Study of the response regulator Rrp1 reveals its regulatory role in chitobiose utilization and virulence of Borrelia burgdorferi.

Sze CW, Smith A, Choi YH, Yang X, Pal U, Yu A, Li C.

Infect Immun. 2013 May;81(5):1775-87. doi: 10.1128/IAI.00050-13. Epub 2013 Mar 11.

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