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pRB, a tumor suppressor with a stabilizing presence.

Manning AL, Dyson NJ.

Trends Cell Biol. 2011 Aug;21(8):433-41. doi: 10.1016/j.tcb.2011.05.003. Epub 2011 Jun 12. Review.


Whole chromosome instability resulting from the synergistic effects of pRB and p53 inactivation.

Manning AL, Benes C, Dyson NJ.

Oncogene. 2014 May 8;33(19):2487-94. doi: 10.1038/onc.2013.201. Epub 2013 Jun 24.


Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive.

Coschi CH, Martens AL, Ritchie K, Francis SM, Chakrabarti S, Berube NG, Dick FA.

Genes Dev. 2010 Jul 1;24(13):1351-63. doi: 10.1101/gad.1917610. Epub 2010 Jun 15.


Suppression of genome instability in pRB-deficient cells by enhancement of chromosome cohesion.

Manning AL, Yazinski SA, Nicolay B, Bryll A, Zou L, Dyson NJ.

Mol Cell. 2014 Mar 20;53(6):993-1004. doi: 10.1016/j.molcel.2014.01.032. Epub 2014 Mar 6.


Loss of pRB causes centromere dysfunction and chromosomal instability.

Manning AL, Longworth MS, Dyson NJ.

Genes Dev. 2010 Jul 1;24(13):1364-76. doi: 10.1101/gad.1917310. Epub 2010 Jun 15.


Activity of the retinoblastoma family proteins, pRB, p107, and p130, during cellular proliferation and differentiation.

Sidle A, Palaty C, Dirks P, Wiggan O, Kiess M, Gill RM, Wong AK, Hamel PA.

Crit Rev Biochem Mol Biol. 1996 Jun;31(3):237-71. Review.


E2f binding-deficient Rb1 protein suppresses prostate tumor progression in vivo.

Sun H, Wang Y, Chinnam M, Zhang X, Hayward SW, Foster BA, Nikitin AY, Wills M, Goodrich DW.

Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):704-9. doi: 10.1073/pnas.1015027108. Epub 2010 Dec 27.


A retinoblastoma allele that is mutated at its common E2F interaction site inhibits cell proliferation in gene-targeted mice.

Cecchini MJ, Thwaites MJ, Talluri S, MacDonald JI, Passos DT, Chong JL, Cantalupo P, Stafford PM, Sáenz-Robles MT, Francis SM, Pipas JM, Leone G, Welch I, Dick FA.

Mol Cell Biol. 2014 Jun;34(11):2029-45. doi: 10.1128/MCB.01589-13. Epub 2014 Mar 24.


pRB, p107 and the regulation of the E2F transcription factor.

Dyson N.

J Cell Sci Suppl. 1994;18:81-7. Review.


The extreme COOH terminus of the retinoblastoma tumor suppressor protein pRb is required for phosphorylation on Thr-373 and activation of E2F.

Gorges LL, Lents NH, Baldassare JJ.

Am J Physiol Cell Physiol. 2008 Nov;295(5):C1151-60. doi: 10.1152/ajpcell.00300.2008. Epub 2008 Sep 3.


Cyclin-dependent kinase-mediated phosphorylation of RBP1 and pRb promotes their dissociation to mediate release of the SAP30·mSin3·HDAC transcriptional repressor complex.

Suryadinata R, Sadowski M, Steel R, Sarcevic B.

J Biol Chem. 2011 Feb 18;286(7):5108-18. doi: 10.1074/jbc.M110.198473. Epub 2010 Dec 9.


Proapoptotic function of the retinoblastoma tumor suppressor protein.

Ianari A, Natale T, Calo E, Ferretti E, Alesse E, Screpanti I, Haigis K, Gulino A, Lees JA.

Cancer Cell. 2009 Mar 3;15(3):184-94. doi: 10.1016/j.ccr.2009.01.026.


RNAi mediated acute depletion of retinoblastoma protein (pRb) promotes aneuploidy in human primary cells via micronuclei formation.

Amato A, Lentini L, Schillaci T, Iovino F, Di Leonardo A.

BMC Cell Biol. 2009 Nov 2;10:79. doi: 10.1186/1471-2121-10-79.


Regulation of cellular genes in a chromosomal context by the retinoblastoma tumor suppressor protein.

Buchmann AM, Swaminathan S, Thimmapaya B.

Mol Cell Biol. 1998 Aug;18(8):4565-76.


Emerging links between E2F control and mitochondrial function.

Benevolenskaya EV, Frolov MV.

Cancer Res. 2015 Feb 15;75(4):619-23. doi: 10.1158/0008-5472.CAN-14-2173. Epub 2015 Jan 29. Review.


RB: mitotic implications of a tumour suppressor.

Manning AL, Dyson NJ.

Nat Rev Cancer. 2012 Feb 9;12(3):220-6. doi: 10.1038/nrc3216. Review.


The THAP-zinc finger protein THAP1 regulates endothelial cell proliferation through modulation of pRB/E2F cell-cycle target genes.

Cayrol C, Lacroix C, Mathe C, Ecochard V, Ceribelli M, Loreau E, Lazar V, Dessen P, Mantovani R, Aguilar L, Girard JP.

Blood. 2007 Jan 15;109(2):584-94. Epub 2006 Sep 26.


RB1: a prototype tumor suppressor and an enigma.

Dyson NJ.

Genes Dev. 2016 Jul 1;30(13):1492-502. doi: 10.1101/gad.282145.116. Review.


Identification of novel pRb binding sites using CpG microarrays suggests that E2F recruits pRb to specific genomic sites during S phase.

Wells J, Yan PS, Cechvala M, Huang T, Farnham PJ.

Oncogene. 2003 Mar 13;22(10):1445-60.


Mutation of the LXCXE binding cleft of pRb facilitates transformation by ras in vitro but does not promote tumorigenesis in vivo.

Talluri S, Francis SM, Dick FA.

PLoS One. 2013 Aug 6;8(8):e72236. doi: 10.1371/journal.pone.0072236. Print 2013.

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