Similar articles for PMID: 21658021

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1

Bp44mT: an orally active iron chelator of the thiosemicarbazone class with potent anti-tumour efficacy.

Yu Y, Suryo Rahmanto Y, Richardson DR. Yu Y, et al. Br J Pharmacol. 2012 Jan;165(1):148-66. doi: 10.1111/j.1476-5381.2011.01526.x. Br J Pharmacol. 2012. PMID: 21658021 Free PMC article.

2

Methemoglobin formation by triapine, di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT), and other anticancer thiosemicarbazones: identification of novel thiosemicarbazones and therapeutics that prevent this effect.

Quach P, Gutierrez E, Basha MT, Kalinowski DS, Sharpe PC, Lovejoy DB, Bernhardt PV, Jansson PJ, Richardson DR. Quach P, et al. Mol Pharmacol. 2012 Jul;82(1):105-14. doi: 10.1124/mol.112.078964. Epub 2012 Apr 16. Mol Pharmacol. 2012. PMID: 22508546

3

A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics.

Whitnall M, Howard J, Ponka P, Richardson DR. Whitnall M, et al. Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14901-6. doi: 10.1073/pnas.0604979103. Epub 2006 Sep 26. Proc Natl Acad Sci U S A. 2006. PMID: 17003122 Free PMC article.

4

Novel di-2-pyridyl-derived iron chelators with marked and selective antitumor activity: in vitro and in vivo assessment.

Yuan J, Lovejoy DB, Richardson DR. Yuan J, et al. Blood. 2004 Sep 1;104(5):1450-8. doi: 10.1182/blood-2004-03-0868. Epub 2004 May 18. Blood. 2004. PMID: 15150082 Free article.

5

The potent and novel thiosemicarbazone chelators di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone and 2-benzoylpyridine-4,4-dimethyl-3-thiosemicarbazone affect crucial thiol systems required for ribonucleotide reductase activity.

Yu Y, Suryo Rahmanto Y, Hawkins CL, Richardson DR. Yu Y, et al. Mol Pharmacol. 2011 Jun;79(6):921-31. doi: 10.1124/mol.111.071324. Epub 2011 Mar 9. Mol Pharmacol. 2011. PMID: 21389104

6

Synthesis and biological evaluation of 2-benzoylpyridine thiosemicarbazones in a dimeric system: structure-activity relationship studies on their anti-proliferative and iron chelation efficacy.

Lukmantara AY, Kalinowski DS, Kumar N, Richardson DR. Lukmantara AY, et al. J Inorg Biochem. 2014 Dec;141:43-54. doi: 10.1016/j.jinorgbio.2014.07.020. Epub 2014 Aug 7. J Inorg Biochem. 2014. PMID: 25217717

7

The Anticancer Agent, Di-2-Pyridylketone 4,4-Dimethyl-3-Thiosemicarbazone (Dp44mT), Up-Regulates the AMPK-Dependent Energy Homeostasis Pathway in Cancer Cells.

Krishan S, Richardson DR, Sahni S. Krishan S, et al. Biochim Biophys Acta. 2016 Dec;1863(12):2916-2933. doi: 10.1016/j.bbamcr.2016.09.011. Epub 2016 Sep 15. Biochim Biophys Acta. 2016. PMID: 27639899 Free article.

8

Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo.

Lovejoy DB, Sharp DM, Seebacher N, Obeidy P, Prichard T, Stefani C, Basha MT, Sharpe PC, Jansson PJ, Kalinowski DS, Bernhardt PV, Richardson DR. Lovejoy DB, et al. J Med Chem. 2012 Aug 23;55(16):7230-44. doi: 10.1021/jm300768u. Epub 2012 Aug 3. J Med Chem. 2012. PMID: 22861499

9

Transcriptional regulation of the cyclin-dependent kinase inhibitor, p21^CIP1/WAF1, by the chelator, Dp44mT.

Moussa RS, Kovacevic Z, Bae DH, Lane DJR, Richardson DR. Moussa RS, et al. Biochim Biophys Acta Gen Subj. 2018 Mar;1862(3):761-774. doi: 10.1016/j.bbagen.2017.10.009. Epub 2017 Oct 13. Biochim Biophys Acta Gen Subj. 2018. PMID: 29032246

10

Iron Chelators: Development of Novel Compounds with High and Selective Anti-Tumour Activity.

Kovacevic Z, Kalinowski DS, Lovejoy DB, Quach P, Wong J, Richardson DR. Kovacevic Z, et al. Curr Drug Deliv. 2010 Jul;7(3):194-207. doi: 10.2174/156720110791560991. Curr Drug Deliv. 2010. PMID: 20507267 Review.

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