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Items: 1 to 20 of 116


An attempt to induce "Graves' disease of the gonads" by immunizing mice with the luteinizing hormone receptor provides insight into breaking tolerance to self-antigens.

Chen CR, Aliesky HA, Rapoport B, McLachlan SM.

Thyroid. 2011 Jul;21(7):773-81. doi: 10.1089/thy.2010.0460. Epub 2011 Jun 7.


Effects of a thyroid-stimulating human monoclonal autoantibody (M22) on functional activity of LH and FSH receptors.

Tonacchera M, Ferrarini E, Dimida A, Agretti P, De Marco G, Pinchera A, Sanders J, Evans M, Richards T, Furmaniak J, Smith BR.

Thyroid. 2006 Nov;16(11):1085-9.


TSH receptor antibodies do not alter the function of gonadotropin receptors stably expressed in eukaryotic cells.

Tonacchera M, Ferrarini E, Dimida A, Agretti P, De Marco G, De Servi M, Chiovato L, Cetani F, Vitti P, Pinchera A.

Eur J Endocrinol. 2004 Mar;150(3):381-7.


Attenuation of induced hyperthyroidism in mice by pretreatment with thyrotropin receptor protein: deviation of thyroid-stimulating to nonfunctional antibodies.

Misharin AV, Nagayama Y, Aliesky HA, Mizutori Y, Rapoport B, McLachlan SM.

Endocrinology. 2009 Aug;150(8):3944-52. doi: 10.1210/en.2009-0181. Epub 2009 Apr 23.


Low-dose immunization with adenovirus expressing the thyroid-stimulating hormone receptor A-subunit deviates the antibody response toward that of autoantibodies in human Graves' disease.

Chen CR, Pichurin P, Chazenbalk GD, Aliesky H, Nagayama Y, McLachlan SM, Rapoport B.

Endocrinology. 2004 Jan;145(1):228-33. Epub 2003 Oct 23.


Evidence that TSH Receptor A-Subunit Multimers, Not Monomers, Drive Antibody Affinity Maturation in Graves' Disease.

Rapoport B, Aliesky HA, Chen CR, McLachlan SM.

J Clin Endocrinol Metab. 2015 Jun;100(6):E871-5. doi: 10.1210/jc.2015-1528. Epub 2015 Apr 9.


Targeted expression of the human thyrotropin receptor A-subunit to the mouse thyroid: insight into overcoming the lack of response to A-subunit adenovirus immunization.

Pichurin PN, Chen CR, Chazenbalk GD, Aliesky H, Pham N, Rapoport B, McLachlan SM.

J Immunol. 2006 Jan 1;176(1):668-76.


The formation of thyrotropin receptor (TSHR) antibodies in a Graves' animal model requires the N-terminal segment of the TSHR extracellular domain.

Kikuoka S, Shimojo N, Yamaguchi KI, Watanabe Y, Hoshioka A, Hirai A, Saito Y, Tahara K, Kohn LD, Maruyama N, Kohno Y, Niimi H.

Endocrinology. 1998 Apr;139(4):1891-8.


Review and hypothesis: does Graves' disease develop in non-human great apes?

McLachlan SM, Alpi K, Rapoport B.

Thyroid. 2011 Dec;21(12):1359-66. doi: 10.1089/thy.2011.0209. Epub 2011 Nov 8. Review. Erratum in: Thyroid. 2012 Feb;22(2):233.


Evidence that shed thyrotropin receptor A subunits drive affinity maturation of autoantibodies causing Graves' disease.

Mizutori Y, Chen CR, Latrofa F, McLachlan SM, Rapoport B.

J Clin Endocrinol Metab. 2009 Mar;94(3):927-35. doi: 10.1210/jc.2008-2134. Epub 2008 Dec 9.


Role of self-tolerance and chronic stimulation in the long-term persistence of adenovirus-induced thyrotropin receptor antibodies in wild-type and transgenic mice.

McLachlan SM, Aliesky HA, Chen CR, Rapoport B.

Thyroid. 2012 Sep;22(9):931-7. doi: 10.1089/thy.2012.0008. Epub 2012 Jul 24.


Enhanced response to mouse thyroid-stimulating hormone (TSH) receptor immunization in TSH receptor-knockout mice.

Nakahara M, Mitsutake N, Sakamoto H, Chen CR, Rapoport B, McLachlan SM, Nagayama Y.

Endocrinology. 2010 Aug;151(8):4047-54. doi: 10.1210/en.2010-0315. Epub 2010 Jun 16.


Thyroid antigens, not central tolerance, control responses to immunization in BALB/c versus C57BL/6 mice.

Misharin AV, Rapoport B, McLachlan SM.

Thyroid. 2009 May;19(5):503-9. doi: 10.1089/thy.2008.0420.


Studies in mice deficient for the autoimmune regulator (Aire) and transgenic for the thyrotropin receptor reveal a role for Aire in tolerance for thyroid autoantigens.

Misharin AV, Nagayama Y, Aliesky HA, Rapoport B, McLachlan SM.

Endocrinology. 2009 Jun;150(6):2948-56. doi: 10.1210/en.2008-1690. Epub 2009 Mar 5.


Adenovirus encoding the thyrotropin receptor A-subunit improves the efficacy of dendritic cell-induced Graves' hyperthyroidism in mice.

Mizutori Y, Saitoh O, Eguchi K, Nagayama Y.

J Autoimmun. 2006 Feb;26(1):32-6. Epub 2005 Oct 18.


"Hijacking" the thyrotropin receptor: A chimeric receptor-lysosome associated membrane protein enhances deoxyribonucleic acid vaccination and induces Graves' hyperthyroidism.

Pichurin PN, Chazenbalk GD, Aliesky H, Pichurina O, Rapoport B, McLachlan SM.

Endocrinology. 2004 Dec;145(12):5504-14. Epub 2004 Aug 26.


Exceptional hyperthyroidism and a role for both major histocompatibility class I and class II genes in a murine model of Graves' disease.

McLachlan SM, Aliesky HA, Chen CR, Williams RW, Rapoport B.

PLoS One. 2011;6(6):e21378. doi: 10.1371/journal.pone.0021378. Epub 2011 Jun 27.


Dendritic cells infected with adenovirus expressing the thyrotrophin receptor induce Graves' hyperthyroidism in BALB/c mice.

Kita-Furuyama M, Nagayama Y, Pichurin P, McLachlan SM, Rapoport B, Eguchi K.

Clin Exp Immunol. 2003 Feb;131(2):234-40.


Genetic immunization of outbred mice with thyrotropin receptor cDNA provides a model of Graves' disease.

Costagliola S, Many MC, Denef JF, Pohlenz J, Refetoff S, Vassart G.

J Clin Invest. 2000 Mar;105(6):803-11.


Antibodies to thyroid peroxidase arise spontaneously with age in NOD.H-2h4 mice and appear after thyroglobulin antibodies.

Chen CR, Hamidi S, Braley-Mullen H, Nagayama Y, Bresee C, Aliesky HA, Rapoport B, McLachlan SM.

Endocrinology. 2010 Sep;151(9):4583-93. doi: 10.1210/en.2010-0321. Epub 2010 Jun 23.

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