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Items: 1 to 20 of 93


Mitochondrial superoxide flashes: metabolic biomarkers of skeletal muscle activity and disease.

Wei L, Salahura G, Boncompagni S, Kasischke KA, Protasi F, Sheu SS, Dirksen RT.

FASEB J. 2011 Sep;25(9):3068-78. doi: 10.1096/fj.11-187252. Epub 2011 Jun 6.


Respective contribution of mitochondrial superoxide and pH to mitochondria-targeted circularly permuted yellow fluorescent protein (mt-cpYFP) flash activity.

Wei-LaPierre L, Gong G, Gerstner BJ, Ducreux S, Yule DI, Pouvreau S, Wang X, Sheu SS, Cheng H, Dirksen RT, Wang W.

J Biol Chem. 2013 Apr 12;288(15):10567-77. doi: 10.1074/jbc.M113.455709. Epub 2013 Mar 1.


Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals.

Fang H, Chen M, Ding Y, Shang W, Xu J, Zhang X, Zhang W, Li K, Xiao Y, Gao F, Shang S, Li JC, Tian XL, Wang SQ, Zhou J, Weisleder N, Ma J, Ouyang K, Chen J, Wang X, Zheng M, Wang W, Zhang X, Cheng H.

Cell Res. 2011 Sep;21(9):1295-304. doi: 10.1038/cr.2011.81. Epub 2011 May 10.


Mitochondrial flash as a novel biomarker of mitochondrial respiration in the heart.

Gong G, Liu X, Zhang H, Sheu SS, Wang W.

Am J Physiol Heart Circ Physiol. 2015 Oct;309(7):H1166-77. doi: 10.1152/ajpheart.00462.2015. Epub 2015 Aug 14.


Differential impact of mitochondrial positioning on mitochondrial Ca(2+) uptake and Ca(2+) spark suppression in skeletal muscle.

Rossi AE, Boncompagni S, Wei L, Protasi F, Dirksen RT.

Am J Physiol Cell Physiol. 2011 Nov;301(5):C1128-39. doi: 10.1152/ajpcell.00194.2011. Epub 2011 Aug 17.


Studies of mitochondrial and nonmitochondrial sources implicate nicotinamide adenine dinucleotide phosphate oxidase(s) in the increased skeletal muscle superoxide generation that occurs during contractile activity.

Sakellariou GK, Vasilaki A, Palomero J, Kayani A, Zibrik L, McArdle A, Jackson MJ.

Antioxid Redox Signal. 2013 Feb 20;18(6):603-21. doi: 10.1089/ars.2012.4623. Epub 2012 Dec 6.


Superoxide flashes in mouse skeletal muscle are produced by discrete arrays of active mitochondria operating coherently.

Pouvreau S.

PLoS One. 2010 Sep 28;5(9). pii: e13035. doi: 10.1371/journal.pone.0013035.


Superoxide constitutes a major signal of mitochondrial superoxide flash.

Zhang X, Huang Z, Hou T, Xu J, Wang Y, Shang W, Ye T, Cheng H, Gao F, Wang X.

Life Sci. 2013 Aug 6;93(4):178-86. doi: 10.1016/j.lfs.2013.06.012. Epub 2013 Jun 22.


Gene dose influences cellular and calcium channel dysregulation in heterozygous and homozygous T4826I-RYR1 malignant hyperthermia-susceptible muscle.

Barrientos GC, Feng W, Truong K, Matthaei KI, Yang T, Allen PD, Lopez JR, Pessah IN.

J Biol Chem. 2012 Jan 20;287(4):2863-76. doi: 10.1074/jbc.M111.307926. Epub 2011 Dec 2.


Role of Mitofusin-2 in mitochondrial localization and calcium uptake in skeletal muscle.

Ainbinder A, Boncompagni S, Protasi F, Dirksen RT.

Cell Calcium. 2015 Jan;57(1):14-24. doi: 10.1016/j.ceca.2014.11.002. Epub 2014 Nov 15.


Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity.

Lustgarten MS, Jang YC, Liu Y, Muller FL, Qi W, Steinhelper M, Brooks SV, Larkin L, Shimizu T, Shirasawa T, McManus LM, Bhattacharya A, Richardson A, Van Remmen H.

Am J Physiol Cell Physiol. 2009 Dec;297(6):C1520-32. doi: 10.1152/ajpcell.00372.2009. Epub 2009 Sep 23.


Mitoflash altered by metabolic stress in insulin-resistant skeletal muscle.

Ding Y, Fang H, Shang W, Xiao Y, Sun T, Hou N, Pan L, Sun X, Ma Q, Zhou J, Wang X, Zhang X, Cheng H.

J Mol Med (Berl). 2015 Oct;93(10):1119-30. doi: 10.1007/s00109-015-1278-y. Epub 2015 Apr 25.


Functional and biochemical properties of ryanodine receptor type 1 channels from heterozygous R163C malignant hyperthermia-susceptible mice.

Feng W, Barrientos GC, Cherednichenko G, Yang T, Padilla IT, Truong K, Allen PD, Lopez JR, Pessah IN.

Mol Pharmacol. 2011 Mar;79(3):420-31. doi: 10.1124/mol.110.067959. Epub 2010 Dec 14.


Fiber hypertrophy and increased oxidative capacity can occur simultaneously in pig glycolytic skeletal muscle.

Scheffler TL, Scheffler JM, Park S, Kasten SC, Wu Y, McMillan RP, Hulver MW, Frisard MI, Gerrard DE.

Am J Physiol Cell Physiol. 2014 Feb 15;306(4):C354-63. doi: 10.1152/ajpcell.00002.2013. Epub 2013 Dec 4.


A retrograde signal from RyR1 alters DHP receptor inactivation and limits window Ca2+ release in muscle fibers of Y522S RyR1 knock-in mice.

Andronache Z, Hamilton SL, Dirksen RT, Melzer W.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4531-6. doi: 10.1073/pnas.0812661106. Epub 2009 Feb 25.


Characterization and temporal development of cores in a mouse model of malignant hyperthermia.

Boncompagni S, Rossi AE, Micaroni M, Hamilton SL, Dirksen RT, Franzini-Armstrong C, Protasi F.

Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21996-2001. doi: 10.1073/pnas.0911496106. Epub 2009 Dec 4.


Superoxide flashes in single mitochondria.

Wang W, Fang H, Groom L, Cheng A, Zhang W, Liu J, Wang X, Li K, Han P, Zheng M, Yin J, Wang W, Mattson MP, Kao JP, Lakatta EG, Sheu SS, Ouyang K, Chen J, Dirksen RT, Cheng H.

Cell. 2008 Jul 25;134(2):279-90. doi: 10.1016/j.cell.2008.06.017.


Mitochondrial superoxide production in skeletal muscle fibers of the rat and decreased fiber excitability.

van der Poel C, Edwards JN, Macdonald WA, Stephenson DG.

Am J Physiol Cell Physiol. 2007 Apr;292(4):C1353-60. Epub 2006 Nov 22.


Study of regulation of mitochondrial respiration in vivo. An analysis of influence of ADP diffusion and possible role of cytoskeleton.

Kay L, Li Z, Mericskay M, Olivares J, Tranqui L, Fontaine E, Tiivel T, Sikk P, Kaambre T, Samuel JL, Rappaport L, Usson Y, Leverve X, Paulin D, Saks VA.

Biochim Biophys Acta. 1997 Nov 10;1322(1):41-59.


O2(*-) production at 37 degrees C plays a critical role in depressing tetanic force of isolated rat and mouse skeletal muscle.

Edwards JN, Macdonald WA, van der Poel C, Stephenson DG.

Am J Physiol Cell Physiol. 2007 Aug;293(2):C650-60. Epub 2007 Apr 25.

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