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Decreased cell adhesion promotes angiogenesis in a Pyk2-dependent manner.

Shen CJ, Raghavan S, Xu Z, Baranski JD, Yu X, Wozniak MA, Miller JS, Gupta M, Buckbinder L, Chen CS.

Exp Cell Res. 2011 Aug 1;317(13):1860-71. doi: 10.1016/j.yexcr.2011.05.006. Epub 2011 May 18.


Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK.

Weis SM, Lim ST, Lutu-Fuga KM, Barnes LA, Chen XL, Göthert JR, Shen TL, Guan JL, Schlaepfer DD, Cheresh DA.

J Cell Biol. 2008 Apr 7;181(1):43-50. doi: 10.1083/jcb.200710038.


B cell receptor-induced phosphorylation of Pyk2 and focal adhesion kinase involves integrins and the Rap GTPases and is required for B cell spreading.

Tse KW, Dang-Lawson M, Lee RL, Vong D, Bulic A, Buckbinder L, Gold MR.

J Biol Chem. 2009 Aug 21;284(34):22865-77. doi: 10.1074/jbc.M109.013169. Epub 2009 Jun 26.


Central role of calcium-dependent tyrosine kinase PYK2 in endothelial nitric oxide synthase-mediated angiogenic response and vascular function.

Matsui A, Okigaki M, Amano K, Adachi Y, Jin D, Takai S, Yamashita T, Kawashima S, Kurihara T, Miyazaki M, Tateishi K, Matsunaga S, Katsume A, Honshou S, Takahashi T, Matoba S, Kusaba T, Tatsumi T, Matsubara H.

Circulation. 2007 Aug 28;116(9):1041-51. Epub 2007 Aug 13.


Pyk2/CAKbeta tyrosine kinase activity-mediated angiogenesis of pulmonary vascular endothelial cells.

Tang H, Hao Q, Fitzgerald T, Sasaki T, Landon EJ, Inagami T.

J Biol Chem. 2002 Feb 15;277(7):5441-7. Epub 2001 Dec 5.


Induction of proline-rich tyrosine kinase 2 activation-mediated C6 glioma cell invasion after anti-vascular endothelial growth factor therapy.

Xu CS, Wang ZF, Dai LM, Chu SH, Gong LL, Yang MH, Li ZQ.

J Transl Med. 2014 May 27;12:148. doi: 10.1186/1479-5876-12-148.


Early inflammatory reactions in atherosclerosis are induced by proline-rich tyrosine kinase/reactive oxygen species-mediated release of tumor necrosis factor-alpha and subsequent activation of the p21Cip1/Ets-1/p300 system.

Katsume A, Okigaki M, Matsui A, Che J, Adachi Y, Kishita E, Yamaguchi S, Ikeda K, Ueyama T, Matoba S, Yamada H, Matsubara H.

Arterioscler Thromb Vasc Biol. 2011 May;31(5):1084-92. doi: 10.1161/ATVBAHA.110.221804. Epub 2011 Mar 3. Retraction in: Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):e6.


Expression of focal adhesion kinase (p125 FAK) and proline-rich tyrosine kinase 2 (PYK2/CAKb) in cerebral metastases, correlation with VEGF-R-, ecNOS III-labelling and morphometric data.

Ludwig HC, Akhavan-Shigari R, Rausch S, Schallock K, Quentin C, Bockermann V, Kolenda H.

Anticancer Res. 2000 May-Jun;20(3A):1419-24.


Vascular endothelial growth factor-mediated activation of p38 is dependent upon Src and RAFTK/Pyk2.

McMullen M, Keller R, Sussman M, Pumiglia K.

Oncogene. 2004 Feb 12;23(6):1275-82.


Regulation of endothelial cell function BY FAK and PYK2.

Orr AW, Murphy-Ullrich JE.

Front Biosci. 2004 May 1;9:1254-66. Review.


EGFL7 is expressed in bone microenvironment and promotes angiogenesis via ERK, STAT3, and integrin signaling cascades.

Chim SM, Kuek V, Chow ST, Lim BS, Tickner J, Zhao J, Chung R, Su YW, Zhang G, Erber W, Xian CJ, Rosen V, Xu J.

J Cell Physiol. 2015 Jan;230(1):82-94. doi: 10.1002/jcp.24684.


Hypertension promotes phosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 in rats: implication for the pathogenesis of hypertensive vascular disease.

Sugimura K, Fukumoto Y, Nawata J, Wang H, Onoue N, Tada T, Shirato K, Shimokawa H.

Tohoku J Exp Med. 2010 Nov;222(3):201-10.


Molecular profile of endothelial invasion of three-dimensional collagen matrices: insights into angiogenic sprout induction in wound healing.

Su SC, Mendoza EA, Kwak HI, Bayless KJ.

Am J Physiol Cell Physiol. 2008 Nov;295(5):C1215-29. doi: 10.1152/ajpcell.00336.2008. Epub 2008 Sep 11.

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